product summary
company name :
Developmental Studies Hybridoma Bank
product type :
antibody
product name :
Keratin, type II/ Cytokeratin 8
catalog :
TROMA-I
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
TROMA-I
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, FACS, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section, western blot knockout validation, immunohistochemistry knockout validation
citations: 133
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; mouse; fig 3
  • western blot knockout validation; human; fig 5
Misiorek J, Lähdeniemi I, Nyström J, Paramonov V, Gullmets J, Saarento H, et al. Keratin 8-deletion induced colitis predisposes to murine colorectal cancer enforced by the inflammasome and IL-22 pathway. Carcinogenesis. 2016;37:777-786 pubmed publisher
  • immunohistochemistry knockout validation; mouse; 1:50; fig 1
  • western blot; mouse; 1:500; fig s3
  • immunohistochemistry - paraffin section; human; 1:50; fig 2
Wögenstein K, Szabo S, Lunova M, Wiche G, Haybaeck J, Strnad P, et al. Epiplakin deficiency aggravates murine caerulein-induced acute pancreatitis and favors the formation of acinar keratin granules. PLoS ONE. 2014;9:e108323 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 7c
Ide S, Kobayashi Y, Ide K, Strausser S, Abe K, Herbek S, et al. Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair. elife. 2021;10: pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 4e
Molina L, Zhu J, Li Q, Pradhan Sundd T, Krutsenko Y, Sayed K, et al. Compensatory hepatic adaptation accompanies permanent absence of intrahepatic biliary network due to YAP1 loss in liver progenitors. Cell Rep. 2021;36:109310 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:400; loading ...; fig s1e
Brady N, Bagadion A, Singh R, Conteduca V, Van Emmenis L, Arceci E, et al. Temporal evolution of cellular heterogeneity during the progression to advanced AR-negative prostate cancer. Nat Commun. 2021;12:3372 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; fig 5e
Benítez S, Cordero A, Santamaria P, Redondo Pedraza J, Rocha A, Collado Solé A, et al. RANK links senescence to stemness in the mammary epithelia, delaying tumor onset but increasing tumor aggressiveness. Dev Cell. 2021;56:1727-1741.e7 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 2a, 3i
Ni N, Fang X, Li Q. Functional similarity between TGF-beta type 2 and type 1 receptors in the female reproductive tract. Sci Rep. 2021;11:9294 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig s3b
Carstens J, Yang S, Correa de Sampaio P, Zheng X, Barua S, McAndrews K, et al. Stabilized epithelial phenotype of cancer cells in primary tumors leads to increased colonization of liver metastasis in pancreatic cancer. Cell Rep. 2021;35:108990 pubmed publisher
  • immunohistochemistry; mouse; loading ...
Wilson M, Reske J, Holladay J, Neupane S, Ngo J, Cuthrell N, et al. ARID1A Mutations Promote P300-Dependent Endometrial Invasion through Super-Enhancer Hyperacetylation. Cell Rep. 2020;33:108366 pubmed publisher
  • immunohistochemistry - frozen section; human; 1:200; fig 3c
Hall B, Gleiberman A, Strom E, Krasnov P, Frescas D, Vujcic S, et al. Immune checkpoint protein VSIG4 as a biomarker of aging in murine adipose tissue. Aging Cell. 2020;19:e13219 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 1a
Neubarth N, Emanuel A, Liu Y, Springel M, Handler A, Zhang Q, et al. Meissner corpuscles and their spatially intermingled afferents underlie gentle touch perception. Science. 2020;368: pubmed publisher
  • immunohistochemistry; mouse; 1:1000; loading ...; fig 4a
Sun X, Are A, Annusver K, Sivan U, Jacob T, Dalessandri T, et al. Coordinated hedgehog signaling induces new hair follicles in adult skin. elife. 2020;9: pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig 1b
Fan D, Chettouh Z, Consalez G, Brunet J. Taste bud formation depends on taste nerves. elife. 2019;8: pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:50; loading ...; fig 2a
Abdo H, Calvo Enrique L, Lopez J, Song J, Zhang M, Usoskin D, et al. Specialized cutaneous Schwann cells initiate pain sensation. Science. 2019;365:695-699 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig 5a
Saykali B, Mathiah N, Nahaboo W, Racu M, Hammou L, Defrance M, et al. Distinct mesoderm migration phenotypes in extra-embryonic and embryonic regions of the early mouse embryo. elife. 2019;8: pubmed publisher
  • immunocytochemistry; mouse; 1:10; loading ...; fig 1a
Jung H, Fattet L, Tsai J, Kajimoto T, Chang Q, Newton A, et al. Apical-basal polarity inhibits epithelial-mesenchymal transition and tumour metastasis by PAR-complex-mediated SNAI1 degradation. Nat Cell Biol. 2019;21:359-371 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:20,000; loading ...; fig 2c
Abeln M, Albers I, Peters Bernard U, Flächsig Schulz K, Kats E, Kispert A, et al. Sialic acid is a critical fetal defense against maternal complement attack. J Clin Invest. 2019;129:422-436 pubmed publisher
  • immunohistochemistry; mouse; 1:30; loading ...; fig 4a
Mao S, Park M, Cabrera R, Christin J, Karagiannis G, Oktay M, et al. Loss of amphiregulin reduces myoepithelial cell coverage of mammary ducts and alters breast tumor growth. Breast Cancer Res. 2018;20:131 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig 1i
Chakrabarti R, Celià Terrassa T, Kumar S, Hang X, Wei Y, Choudhury A, et al. Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche. Science. 2018;360: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:50; loading ...; fig 2e
Takai K, Drain A, Lawson D, Littlepage L, Karpuj M, Kessenbrock K, et al. Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive basal-like breast cancers. Genes Dev. 2018;32:244-257 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 2j
Watanabe Y, Miyasaka K, Kubo A, Kida Y, Nakagawa O, Hirate Y, et al. Notch and Hippo signaling converge on Strawberry Notch 1 (Sbno1) to synergistically activate Cdx2 during specification of the trophectoderm. Sci Rep. 2017;7:46135 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 2d
Saarela U, Akram S, Desgrange A, Rak Raszewska A, Shan J, Cereghini S, et al. Novel fixed z-direction (FiZD) kidney primordia and an organoid culture system for time-lapse confocal imaging. Development. 2017;144:1113-1117 pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig s5a
Fu N, Rios A, Pal B, Law C, Jamieson P, Liu R, et al. Identification of quiescent and spatially restricted mammary stem cells that are hormone responsive. Nat Cell Biol. 2017;19:164-176 pubmed publisher
  • immunohistochemistry - frozen section; human; 1:20; loading ...; fig 6b
Wu J, Platero Luengo A, Sakurai M, Sugawara A, Gil M, Yamauchi T, et al. Interspecies Chimerism with Mammalian Pluripotent Stem Cells. Cell. 2017;168:473-486.e15 pubmed publisher
  • immunohistochemistry; mouse; 1:50; loading ...; fig s3
Abraira V, Kuehn E, Chirila A, Springel M, Toliver A, Zimmerman A, et al. The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn. Cell. 2017;168:295-310.e19 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 6c
Lloyd Lewis B, Davis F, Harris O, Hitchcock J, Lourenco F, Pasche M, et al. Imaging the mammary gland and mammary tumours in 3D: optical tissue clearing and immunofluorescence methods. Breast Cancer Res. 2016;18:127 pubmed
  • immunohistochemistry; mouse; 1:500; loading ...
Yang Z, Peng Y, Gopalan A, Gao D, Chen Y, Joyner A. Stromal hedgehog signaling maintains smooth muscle and hampers micro-invasive prostate cancer. Dis Model Mech. 2017;10:39-52 pubmed publisher
  • immunohistochemistry; mouse; fig 6e
Kugler D, Flomerfelt F, Costa D, Laky K, Kamenyeva O, Mittelstadt P, et al. Systemic toxoplasma infection triggers a long-term defect in the generation and function of naive T lymphocytes. J Exp Med. 2016;213:3041-3056 pubmed
  • immunohistochemistry - paraffin section; mouse; 1:400; loading ...; fig 3b
Sizemore G, Balakrishnan S, Hammer A, Thies K, Trimboli A, Wallace J, et al. Stromal PTEN inhibits the expansion of mammary epithelial stem cells through Jagged-1. Oncogene. 2017;36:2297-2308 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:50; loading ...; fig 1b
Davis F, Lloyd Lewis B, Harris O, Kozar S, Winton D, Muresan L, et al. Single-cell lineage tracing in the mammary gland reveals stochastic clonal dispersion of stem/progenitor cell progeny. Nat Commun. 2016;7:13053 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500; fig 1
Perdigoto C, Dauber K, Bar C, Tsai P, Valdes V, Cohen I, et al. Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact to Regulate Merkel Cell Specification during Skin Development. PLoS Genet. 2016;12:e1006151 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500; loading ...; fig s4h
Wuidart A, Ousset M, Rulands S, Simons B, Van Keymeulen A, Blanpain C. Quantitative lineage tracing strategies to resolve multipotency in tissue-specific stem cells. Genes Dev. 2016;30:1261-77 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig s1
Mancini M, Lien E, Toker A. Oncogenic AKT1(E17K) mutation induces mammary hyperplasia but prevents HER2-driven tumorigenesis. Oncotarget. 2016;7:17301-13 pubmed publisher
  • immunohistochemistry; mouse; 1:100; fig 3
Nair S, Zhang X, Chiang H, Jahid M, Wang Y, Garza P, et al. Genetic suppression reveals DNA repair-independent antagonism between BRCA1 and COBRA1 in mammary gland development. Nat Commun. 2016;7:10913 pubmed publisher
  • immunocytochemistry; mouse; fig 2
Pajoohesh Ganji A, Pal Ghosh S, Tadvalkar G, Stepp M. K14 + compound niches are present on the mouse cornea early after birth and expand after debridement wounds. Dev Dyn. 2016;245:132-43 pubmed publisher
  • immunohistochemistry; mouse; 1:100; fig 3
Manda K, Tripathi P, Hsi A, Ning J, Ruzinova M, Liapis H, et al. NFATc1 promotes prostate tumorigenesis and overcomes PTEN loss-induced senescence. Oncogene. 2016;35:3282-92 pubmed publisher
  • immunohistochemistry; mouse; 1:50; fig 5
Davila J, Laws M, Kannan A, Li Q, Taylor R, Bagchi M, et al. Rac1 Regulates Endometrial Secretory Function to Control Placental Development. PLoS Genet. 2015;11:e1005458 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:250; fig s2
Chang C, Zhang M, Rajapakshe K, Coarfa C, Edwards D, Huang S, et al. Mammary Stem Cells and Tumor-Initiating Cells Are More Resistant to Apoptosis and Exhibit Increased DNA Repair Activity in Response to DNA Damage. Stem Cell Reports. 2015;5:378-91 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:20; fig 2
Ostrowski S, Wright M, Bolock A, Geng X, Maricich S. Ectopic Atoh1 expression drives Merkel cell production in embryonic, postnatal and adult mouse epidermis. Development. 2015;142:2533-44 pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig 1a
Hein S, Haricharan S, Johnston A, Toneff M, Reddy J, Dong J, et al. Luminal epithelial cells within the mammary gland can produce basal cells upon oncogenic stress. Oncogene. 2016;35:1461-7 pubmed publisher
  • immunohistochemistry; human
  • immunohistochemistry; mouse
Franckaert D, Schlenner S, Heirman N, Gill J, Skogberg G, Ekwall O, et al. Premature thymic involution is independent of structural plasticity of the thymic stroma. Eur J Immunol. 2015;45:1535-47 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100
Chandler R, Damrauer J, Raab J, Schisler J, Wilkerson M, Didion J, et al. Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling. Nat Commun. 2015;6:6118 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:20; fig 1
Wright M, Reed Geaghan E, Bolock A, Fujiyama T, Hoshino M, Maricich S. Unipotent, Atoh1+ progenitors maintain the Merkel cell population in embryonic and adult mice. J Cell Biol. 2015;208:367-79 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:250; fig 4
Roarty K, Shore A, Creighton C, Rosen J. Ror2 regulates branching, differentiation, and actin-cytoskeletal dynamics within the mammary epithelium. J Cell Biol. 2015;208:351-66 pubmed publisher
  • immunocytochemistry; mouse; fig 3
Richardson G, Lannigan J, Macara I. Does FACS perturb gene expression?. Cytometry A. 2015;87:166-75 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100
Kunasegaran K, Ho V, Chang T, De Silva D, Bakker M, Christoffels V, et al. Transcriptional repressor Tbx3 is required for the hormone-sensing cell lineage in mammary epithelium. PLoS ONE. 2014;9:e110191 pubmed publisher
  • immunohistochemistry - paraffin section; human
Sato M, Kadota M, Tang B, Yang H, Yang Y, Shan M, et al. An integrated genomic approach identifies persistent tumor suppressive effects of transforming growth factor-? in human breast cancer. Breast Cancer Res. 2014;16:R57 pubmed publisher
  • western blot; human; fig 2
Mashukova A, Kozhekbaeva Z, Forteza R, Dulam V, Figueroa Y, Warren R, et al. The BAG-1 isoform BAG-1M regulates keratin-associated Hsp70 chaperoning of aPKC in intestinal cells during activation of inflammatory signaling. J Cell Sci. 2014;127:3568-77 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100
Gao Y, Bayless K, Li Q. TGFBR1 is required for mouse myometrial development. Mol Endocrinol. 2014;28:380-94 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100
Huang T, Krimm R. BDNF and NT4 play interchangeable roles in gustatory development. Dev Biol. 2014;386:308-20 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:250
Bray K, Gillette M, Young J, Loughran E, Hwang M, Sears J, et al. Cdc42 overexpression induces hyperbranching in the developing mammary gland by enhancing cell migration. Breast Cancer Res. 2013;15:R91 pubmed
  • immunocytochemistry; mouse; 1:100
Stewart C, Wang Y, Bonilla Claudio M, Martin J, Gonzalez G, Taketo M, et al. CTNNB1 in mesenchyme regulates epithelial cell differentiation during Müllerian duct and postnatal uterine development. Mol Endocrinol. 2013;27:1442-54 pubmed publisher
  • immunohistochemistry - paraffin section; mouse
Sizemore G, Sizemore S, Pal B, Booth C, Seachrist D, Abdul Karim F, et al. FOXC1 is enriched in the mammary luminal progenitor population, but is not necessary for mouse mammary ductal morphogenesis. Biol Reprod. 2013;89:10 pubmed publisher
  • immunohistochemistry; mouse; 1:200
Tripathi P, Wang Y, Coussens M, Manda K, Casey A, Lin C, et al. Activation of NFAT signaling establishes a tumorigenic microenvironment through cell autonomous and non-cell autonomous mechanisms. Oncogene. 2014;33:1840-9 pubmed publisher
  • immunohistochemistry; mouse; 1:100
Patel A, Huang T, Krimm R. Lingual and palatal gustatory afferents each depend on both BDNF and NT-4, but the dependence is greater for lingual than palatal afferents. J Comp Neurol. 2010;518:3290-301 pubmed publisher
Qi Y, Liu J, Chao J, Greer P, Li S. PTEN dephosphorylates Abi1 to promote epithelial morphogenesis. J Cell Biol. 2020;219: pubmed publisher
Mori S, Sakakura E, Tsunekawa Y, Hagiwara M, Suzuki T, Eiraku M. Self-organized formation of developing appendages from murine pluripotent stem cells. Nat Commun. 2019;10:3802 pubmed publisher
Wilson M, Reske J, Holladay J, Wilber G, Rhodes M, Koeman J, et al. ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion. Nat Commun. 2019;10:3554 pubmed publisher
Low J, Li P, Chew E, Zhou B, Suzuki K, Zhang T, et al. Generation of Human PSC-Derived Kidney Organoids with Patterned Nephron Segments and a De Novo Vascular Network. Cell Stem Cell. 2019;25:373-387.e9 pubmed publisher
Chatterjee S, Halaoui R, Deagle R, Rejon C, McCaffrey L. Numb regulates cell tension required for mammary duct elongation. Biol Open. 2019;8: pubmed publisher
Tagaya H, Ishikawa K, Hosokawa Y, Kobayashi S, Ueoka Y, Shimada M, et al. A method of producing genetically manipulated mouse mammary gland. Breast Cancer Res. 2019;21:1 pubmed publisher
Kumari A, Yokota Y, Li L, Bradley R, Mistretta C. Species generalization and differences in Hedgehog pathway regulation of fungiform and circumvallate papilla taste function and somatosensation demonstrated with sonidegib. Sci Rep. 2018;8:16150 pubmed publisher
Okano Uchida T, Kent L, Ouseph M, McCarty B, Frank J, Kladney R, et al. Endoreduplication of the mouse genome in the absence of ORC1. Genes Dev. 2018;32:978-990 pubmed publisher
Schroer A, Gross J, Kaski S, Wix K, Siderovski D, Vandenbeuch A, et al. Development of Full Sweet, Umami, and Bitter Taste Responsiveness Requires Regulator of G protein Signaling-21 (RGS21). Chem Senses. 2018;43:367-378 pubmed publisher
Kogut I, McCarthy S, Pavlova M, Astling D, Chen X, Jakimenko A, et al. High-efficiency RNA-based reprogramming of human primary fibroblasts. Nat Commun. 2018;9:745 pubmed publisher
Emmerson E, May A, Berthoin L, Cruz Pacheco N, Nathan S, Mattingly A, et al. Salivary glands regenerate after radiation injury through SOX2-mediated secretory cell replacement. EMBO Mol Med. 2018;10: pubmed publisher
Chen P, Zhang H, Sun X, Hu Y, Jiang W, Liu Z, et al. microRNA-449a modulates medullary thymic epithelial cell differentiation. Sci Rep. 2017;7:15915 pubmed publisher
Girnius N, Davis R. JNK Promotes Epithelial Cell Anoikis by Transcriptional and Post-translational Regulation of BH3-Only Proteins. Cell Rep. 2017;21:1910-1921 pubmed publisher
Sreekumar A, Toneff M, Toh E, Roarty K, Creighton C, Belka G, et al. WNT-Mediated Regulation of FOXO1 Constitutes a Critical Axis Maintaining Pubertal Mammary Stem Cell Homeostasis. Dev Cell. 2017;43:436-448.e6 pubmed publisher
Jain R, Sheridan J, Policheni A, Heinlein M, Gandolfo L, Dewson G, et al. A critical epithelial survival axis regulated by MCL-1 maintains thymic function in mice. Blood. 2017;130:2504-2515 pubmed publisher
Hindman A, Mo X, Helber H, Kovalchin C, Ravichandran N, Murphy A, et al. Varying Susceptibility of the Female Mammary Gland to In Utero Windows of BPA Exposure. Endocrinology. 2017;158:3435-3447 pubmed publisher
Speroni L, Voutilainen M, Mikkola M, Klager S, Schaeberle C, Sonnenschein C, et al. New insights into fetal mammary gland morphogenesis: differential effects of natural and environmental estrogens. Sci Rep. 2017;7:40806 pubmed publisher
Liu Y, Wang Y, Du Z, Yan X, Zheng P, Liu Y. Fbxo30 Regulates Mammopoiesis by Targeting the Bipolar Mitotic Kinesin Eg5. Cell Rep. 2016;15:1111-1122 pubmed publisher
Garfin P, Nguyen T, Sage J. Loss of Pten Disrupts the Thymic Epithelium and Alters Thymic Function. PLoS ONE. 2016;11:e0149430 pubmed publisher
Biggs B, Tang T, Krimm R. Insulin-Like Growth Factors Are Expressed in the Taste System, but Do Not Maintain Adult Taste Buds. PLoS ONE. 2016;11:e0148315 pubmed publisher
Sun X, Deng W, Li Y, Tang S, Leishman E, Bradshaw H, et al. Sustained Endocannabinoid Signaling Compromises Decidual Function and Promotes Inflammation-induced Preterm Birth. J Biol Chem. 2016;291:8231-40 pubmed publisher
Shuda M, Guastafierro A, Geng X, Shuda Y, Ostrowski S, Lukianov S, et al. Merkel Cell Polyomavirus Small T Antigen Induces Cancer and Embryonic Merkel Cell Proliferation in a Transgenic Mouse Model. PLoS ONE. 2015;10:e0142329 pubmed publisher
Drobysheva D, Smith B, McDowell M, Guillen K, Ekiz H, Welm B. Transformation of enriched mammary cell populations with polyomavirus middle T antigen influences tumor subtype and metastatic potential. Breast Cancer Res. 2015;17:132 pubmed publisher
Liu Z, Ren Y, Pangas S, Adams J, Zhou W, Castrillon D, et al. FOXO1/3 and PTEN Depletion in Granulosa Cells Promotes Ovarian Granulosa Cell Tumor Development. Mol Endocrinol. 2015;29:1006-24 pubmed publisher
Asghar M, Silvander J, Helenius T, Lähdeniemi I, Alam C, Fortelius L, et al. The amount of keratins matters for stress protection of the colonic epithelium. PLoS ONE. 2015;10:e0127436 pubmed publisher
Helenius T, Misiorek J, Nyström J, Fortelius L, Habtezion A, Liao J, et al. Keratin 8 absence down-regulates colonocyte HMGCS2 and modulates colonic ketogenesis and energy metabolism. Mol Biol Cell. 2015;26:2298-310 pubmed publisher
Kist R, Watson M, Crosier M, Robinson M, Fuchs J, Reichelt J, et al. The formation of endoderm-derived taste sensory organs requires a Pax9-dependent expansion of embryonic taste bud progenitor cells. PLoS Genet. 2014;10:e1004709 pubmed publisher
LeBleu V, O Connell J, Gonzalez Herrera K, Wikman H, Pantel K, Haigis M, et al. PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis. Nat Cell Biol. 2014;16:992-1003, 1-15 pubmed publisher
Wang D, Tiwari A, Kim M, Clemons N, Regmi N, Hodges W, et al. Hedgehog signaling regulates FOXA2 in esophageal embryogenesis and Barrett's metaplasia. J Clin Invest. 2014;124:3767-80 pubmed publisher
Many A, Brown A. Both canonical and non-canonical Wnt signaling independently promote stem cell growth in mammospheres. PLoS ONE. 2014;9:e101800 pubmed publisher
Kumar L, Chou J, Yee C, Borzutzky A, Vollmann E, von Andrian U, et al. Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function. J Exp Med. 2014;211:929-42 pubmed publisher
Shin K, Lim A, Odegaard J, Honeycutt J, Kawano S, Hsieh M, et al. Cellular origin of bladder neoplasia and tissue dynamics of its progression to invasive carcinoma. Nat Cell Biol. 2014;16:469-78 pubmed publisher
Urbach A, Yermalovich A, Zhang J, Spina C, Zhu H, Perez Atayde A, et al. Lin28 sustains early renal progenitors and induces Wilms tumor. Genes Dev. 2014;28:971-82 pubmed publisher
Woo S, Ranade S, Weyer A, Dubin A, Baba Y, Qiu Z, et al. Piezo2 is required for Merkel-cell mechanotransduction. Nature. 2014;509:622-6 pubmed publisher
Cleary A, Leonard T, Gestl S, Gunther E. Tumour cell heterogeneity maintained by cooperating subclones in Wnt-driven mammary cancers. Nature. 2014;508:113-7 pubmed publisher
Laws M, Kannan A, Pawar S, Haschek W, Bagchi M, Bagchi I. Dysregulated estrogen receptor signaling in the hypothalamic-pituitary-ovarian axis leads to ovarian epithelial tumorigenesis in mice. PLoS Genet. 2014;10:e1004230 pubmed publisher
Shamir E, Pappalardo E, Jorgens D, Coutinho K, Tsai W, Aziz K, et al. Twist1-induced dissemination preserves epithelial identity and requires E-cadherin. J Cell Biol. 2014;204:839-56 pubmed publisher
Lesniak D, Marshall K, Wellnitz S, Jenkins B, Baba Y, Rasband M, et al. Computation identifies structural features that govern neuronal firing properties in slowly adapting touch receptors. elife. 2014;3:e01488 pubmed publisher
Chang T, Kunasegaran K, Tarulli G, De Silva D, Voorhoeve P, Pietersen A. New insights into lineage restriction of mammary gland epithelium using parity-identified mammary epithelial cells. Breast Cancer Res. 2014;16:R1 pubmed publisher
Osada M, Singh V, Wu K, Sant Angelo D, Pezzano M. Label retention identifies a multipotent mesenchymal stem cell-like population in the postnatal thymus. PLoS ONE. 2013;8:e83024 pubmed publisher
Kaanta A, Virtanen C, Selfors L, Brugge J, Neel B. Evidence for a multipotent mammary progenitor with pregnancy-specific activity. Breast Cancer Res. 2013;15:R65 pubmed
Hughes M, Jiang T, Lin S, Leung Y, Kobielak K, Widelitz R, et al. Disrupted ectodermal organ morphogenesis in mice with a conditional histone deacetylase 1, 2 deletion in the epidermis. J Invest Dermatol. 2014;134:24-32 pubmed publisher
Sandilands A, Smith F, Lunny D, Campbell L, Davidson K, MacCallum S, et al. Generation and characterisation of keratin 7 (K7) knockout mice. PLoS ONE. 2013;8:e64404 pubmed publisher
Leung A, Kent Morest D, Li J. Differential BMP signaling controls formation and differentiation of multipotent preplacodal ectoderm progenitors from human embryonic stem cells. Dev Biol. 2013;379:208-20 pubmed publisher
Snider N, Leonard J, Kwan R, Griggs N, Rui L, Omary M. Glucose and SIRT2 reciprocally mediate the regulation of keratin 8 by lysine acetylation. J Cell Biol. 2013;200:241-7 pubmed publisher
Forsman C, Ng B, Heinze R, Kuo C, Sergi C, Gopalakrishnan R, et al. BMP-binding protein twisted gastrulation is required in mammary gland epithelium for normal ductal elongation and myoepithelial compartmentalization. Dev Biol. 2013;373:95-106 pubmed publisher
Huang C, Orvis G, Wang Y, Behringer R. Stromal-to-epithelial transition during postpartum endometrial regeneration. PLoS ONE. 2012;7:e44285 pubmed publisher
Diaz Guerra E, Lillo M, Santamaría S, Garcia Sanz J. Intrinsic cues and hormones control mouse mammary epithelial tree size. FASEB J. 2012;26:3844-53 pubmed publisher
Mashukova A, Forteza R, Wald F, SALAS P. PDK1 in apical signaling endosomes participates in the rescue of the polarity complex atypical PKC by intermediate filaments in intestinal epithelia. Mol Biol Cell. 2012;23:1664-74 pubmed publisher
Kim S, Roopra A, Alexander C. A phenotypic mouse model of basaloid breast tumors. PLoS ONE. 2012;7:e30979 pubmed publisher
Schneckenleithner C, Bago Horvath Z, Dolznig H, Neugebauer N, Kollmann K, Kolbe T, et al. Putting the brakes on mammary tumorigenesis: loss of STAT1 predisposes to intraepithelial neoplasias. Oncotarget. 2011;2:1043-54 pubmed
Riggio M, Polo M, Blaustein M, Colman Lerner A, Lüthy I, Lanari C, et al. PI3K/AKT pathway regulates phosphorylation of steroid receptors, hormone independence and tumor differentiation in breast cancer. Carcinogenesis. 2012;33:509-18 pubmed publisher
Snider N, Weerasinghe S, Singla A, Leonard J, Hanada S, Andrews P, et al. Energy determinants GAPDH and NDPK act as genetic modifiers for hepatocyte inclusion formation. J Cell Biol. 2011;195:217-29 pubmed publisher
Kim S, Goel S, Alexander C. Differentiation generates paracrine cell pairs that maintain basaloid mouse mammary tumors: proof of concept. PLoS ONE. 2011;6:e19310 pubmed publisher
Harrison T, Smith Adams L, Moore P, Perna M, Sword J, Defoe D. Accelerated turnover of taste bud cells in mice deficient for the cyclin-dependent kinase inhibitor p27Kip1. BMC Neurosci. 2011;12:34 pubmed publisher
Shaffer M, Huang Y, Corbo E, Wu G, Velez M, Choi J, et al. Ezrin is highly expressed in early thymocytes, but dispensable for T cell development in mice. PLoS ONE. 2010;5:e12404 pubmed publisher
Sakamoto K, Triplett A, Schuler L, Wagner K. Janus kinase 2 is required for the initiation but not maintenance of prolactin-induced mammary cancer. Oncogene. 2010;29:5359-69 pubmed publisher
Osada M, Jardine L, Misir R, Andl T, Millar S, Pezzano M. DKK1 mediated inhibition of Wnt signaling in postnatal mice leads to loss of TEC progenitors and thymic degeneration. PLoS ONE. 2010;5:e9062 pubmed publisher
Sun P, Yuan Y, Li A, Li B, Dai X. Cytokeratin expression during mouse embryonic and early postnatal mammary gland development. Histochem Cell Biol. 2010;133:213-21 pubmed publisher
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product information
Internal ID :
1388
Name :
TROMA-I
Depositor Name :
Brulet, P. / Kemler, R.
Depositor Institution :
Institut Pasteur
Date Deposited :
2/13/87
Allow Hybridoma Distribution :
Yes
Cells Available (legacy) :
Yes
Antigen :
Keratin, type II/ Cytokeratin 8
Antigen Species :
Mouse
Host Species :
rat
Isotype :
RIgG2a, kappa light chain
Isotype for catalog (legacy) :
IgG2a, kappa light chain
Positive Tested Species Reactivity :
Human,Mouse
Species Tested (legacy) :
mouse, human
Initial Publication Pubmed ID :
6933460
Depositor Notes (Special Instructions) :
The TROMA-I antibody is also known as EndoA.
Collections :
Cell markers,Cytoskeleton,Human
Search Keywords :
Brulet, Philippe / Kemler, Rolf, Keratin, type II cytoskeletal 8; Cytokeratin end A, Mouse, RIgG2a, kappa light chain, Mouse/Human, Krt8, krt2-8, AB_531826, Monoclonal, cytokeratin 8, Endo-A, endoA
Antigen Molecular Weight :
Predicted: 54.5 kDa
Gene :
Krt8
Alternate Gene Name(s) :
krt2-8
Uniprot ID :
P11679
Antibody Registry ID :
AB_531826
Immunogen :
TDM1 (Trophoblastoma) cell line intermediate filaments
Immunogen Sequence :
Full length protein
Clonality :
Monoclonal
Myeloma Strain :
SP2/0
Epitope Mapped :
No
Recommended Applications :
FACS,FFPE,Immunofluorescence,Immunohistochemistry,Immunoprecipitation,Western Blot
Immunoblotting (legacy) :
Yes
Immunohistochemistry Pubmed IDs :
22683848 9749362 12645929 15472905 19665978 24603706 22180571 30611295 31391455 31444329
Immunofluorescence Pubmed IDs :
19040567 15941856 23643939 6171607 6205890 9013327 29162901 26901525 29335337 29701767 27117404 26900150 30385780 31303547
Western Blot Pubmed IDs :
15941856 19202556 18985715 15717849 15170516 6205890
FFPE Pubmed IDs :
15941856 9749362 12645929 15472905 19665978 24603706 31391455
FACS Pubmed IDs :
17823311
Pubmed IDs :
25083987 22180571
Additional Information :
works in paraffin; recognizes keratin 8;
DSHB Growth Medium :
Iscove's
References (legacy) :
Proc. Nat'l. Acad. Sci. 77, 4113-4117.; J. Embryol. Exp. Morph. 64, 45-60.; Exp. Cell Res. 154(1), 315-319.; J. Cell Sci. 109, 2789-2800.; J. Comp. Path. 119, 177-181.; Dev. Biol. 253, 258-263.; Int. J. Cancer 113, 525-532.; Cell 138, 592-603.; PLoS Genet 10(3): doi:10.1371/journal.pgen.1004230.; J. Clin. Invest. doi:10.1172/JCI66603.
company information
Developmental Studies Hybridoma Bank
University of Iowa
http://dshb.biology.uiowa.edu
headquarters: US