Receptor tyrosine kinase-like orphan receptor 2/Ror2 | Developmental Studies Hybridoma Bank Ror2 product information

product summary

company name :

Developmental Studies Hybridoma Bank

product type :

antibody

product name :

Receptor tyrosine kinase-like orphan receptor 2/Ror2

catalog :

Ror2

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

Ror2

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, western blot knockout validation

more info or order :

Developmental Studies Hybridoma Bank product webpage

citations: 7

Published Application/Species/Sample/Dilution	Reference
western blot knockout validation; mouse; fig 3 immunohistochemistry - paraffin section; mouse; 1:100; fig 2	Roarty K, Shore A, Creighton C, Rosen J. Ror2 regulates branching, differentiation, and actin-cytoskeletal dynamics within the mammary epithelium. J Cell Biol. 2015;208:351-66 pubmed publisher
	Roarty K, Pfefferle A, Creighton C, Perou C, Rosen J. Ror2-mediated alternative Wnt signaling regulates cell fate and adhesion during mammary tumor progression. Oncogene. 2017;36:5958-5968 pubmed publisher
	Liu C, Lin C, Gao C, May Simera H, Swaroop A, Li T. Null and hypomorph Prickle1 alleles in mice phenocopy human Robinow syndrome and disrupt signaling downstream of Wnt5a. Biol Open. 2014;3:861-70 pubmed publisher
	van Amerongen R, Fuerer C, Mizutani M, Nusse R. Wnt5a can both activate and repress Wnt/?-catenin signaling during mouse embryonic development. Dev Biol. 2012;369:101-14 pubmed publisher
	Edris B, Espinosa I, Mühlenberg T, Mikels A, Lee C, Steigen S, et al. ROR2 is a novel prognostic biomarker and a potential therapeutic target in leiomyosarcoma and gastrointestinal stromal tumour. J Pathol. 2012;227:223-33 pubmed publisher
	Gao B, Song H, Bishop K, Elliot G, Garrett L, English M, et al. Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2. Dev Cell. 2011;20:163-76 pubmed publisher
	Mikels A, Minami Y, Nusse R. Ror2 receptor requires tyrosine kinase activity to mediate Wnt5A signaling. J Biol Chem. 2009;284:30167-76 pubmed publisher

product information

Internal ID :

6845

Name :

Ror2

Depositor Name :

Nusse, R.

Depositor Institution :

Stanford University

Depositor Website :

http://web.stanford.edu/group/nusselab/cgi-bin/lab/main

Date Deposited :

9/2/10

Allow Hybridoma Distribution :

Yes

Cells Available (legacy) :

Yes

Antigen :

Receptor tyrosine kinase-like orphan receptor 2/Ror2

Antigen Species :

Mouse

Host Species :

mouse

Isotype :

MIgG1

Isotype for catalog (legacy) :

IgG1

Positive Tested Species Reactivity :

Human,Mouse

Species Tested (legacy) :

mouse and human

Initial Publication Pubmed ID :

19720827

Depositor Notes (Special Instructions) :

This antibody does not cross react with Ror1. The antigen is also known as neurotrophic tyrosine kinase, receptor-related 2 and is involved in cartilage growth, growth plate development and hair follicle patterning.

Collections :

Cell signaling,Enzymes,Human

Search Keywords :

Nusse, R., Receptor tyrosine kinase-like orphan receptor 2/Ror2, Mouse, MIgG1, Mouse/Human, Ror2, Ntrkr2, mRor2, AB_10804796, Monoclonal, Human/Enzymes, Immunohistochemistry/Immunofluorescence/Western blot/ELISA/FFPE/Immunoprecipitation

Antigen Molecular Weight :

105 kDa

Gene :

Ror2

Alternate Gene Name(s) :

Ntrkr2, mRor2

Uniprot ID :

Q9Z138

Antibody Registry ID :

AB_10804796

Immunogen :

Ror2-MBP fusion protein

Immunogen Sequence :

NT 2535-2835/ C-terminal 100 amino acids

Clonality :

Monoclonal

Epitope Mapped :

Yes

Epitope Location or Sequence :

C-terminus

Epitope Map PubMed ID :

19720827

Recommended Applications :

ELISA,FFPE,Immunofluorescence,Immunohistochemistry,Immunoprecipitation,Western Blot

Immunoblotting (legacy) :

yes

Immunohistochemistry Pubmed IDs :

19720827 22771246 22294416

Immunofluorescence Pubmed IDs :

19720827 25624393 21316585

Western Blot Pubmed IDs :

19720827 25624393 22294416 21316585

Immunoprecipitation Pubmed IDs :

22294416 21316585

ELISA Pubmed IDs :

19720827

FFPE Pubmed IDs :

19720827 25624393 22771246

DSHB Growth Medium :

Iscove's

References (legacy) :

J. Biol. Chem. 284(44), 30167-30176.

more info or order :

Developmental Studies Hybridoma Bank product webpage