product summary
company name :
Developmental Studies Hybridoma Bank
product type :
antibody
product name :
RAb7/CG5915 protein
catalog :
Rab7
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
Rab7
reactivity :
Drosophila melanogaster
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation
citations: 26
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; Drosophila melanogaster; 1:10; loading ...; fig 1a, 4d
Lorincz P, Kenéz L, Tóth S, Kiss V, Varga A, Csizmadia T, et al. Vps8 overexpression inhibits HOPS-dependent trafficking routes by outcompeting Vps41/Lt. elife. 2019;8: pubmed publisher
  • immunocytochemistry; Drosophila melanogaster; 1:5; loading ...; fig 2h
Valoskova K, Biebl J, Roblek M, Emtenani S, Gyoergy A, Misova M, et al. A conserved major facilitator superfamily member orchestrates a subset of O-glycosylation to aid macrophage tissue invasion. elife. 2019;8: pubmed publisher
Lakatos Z, Lorincz P, Szabo Z, Benkő P, Kenéz L, Csizmadia T, et al. Sec20 is Required for Autophagic and Endocytic Degradation Independent of Golgi-ER Retrograde Transport. Cells. 2019;8: pubmed publisher
Court H, Ahearn I, Amoyel M, Bach E, Philips M. Regulation of NOTCH signaling by RAB7 and RAB8 requires carboxyl methylation by ICMT. J Cell Biol. 2017;216:4165-4182 pubmed publisher
Stephen J, Yokoyama T, Tolman N, O Brien K, Nicoli E, Brooks B, et al. Cellular and molecular defects in a patient with Hermansky-Pudlak syndrome type 5. PLoS ONE. 2017;12:e0173682 pubmed publisher
Rofe A, Davis L, Whittingham J, Latimer Bowman E, Wilkinson A, Pryor P. The Rhodococcus equi virulence protein VapA disrupts endolysosome function and stimulates lysosome biogenesis. Microbiologyopen. 2017;6: pubmed publisher
Maartens A, Wellmann J, Wictome E, Klapholz B, Green H, Brown N. Drosophila vinculin is more harmful when hyperactive than absent, and can circumvent integrin to form adhesion complexes. J Cell Sci. 2016;129:4354-4365 pubmed
Hegedűs K, Takáts S, Boda A, Jipa A, Nagy P, Varga K, et al. The Ccz1-Mon1-Rab7 module and Rab5 control distinct steps of autophagy. Mol Biol Cell. 2016;27:3132-3142 pubmed
Riedel F, Gillingham A, Rosa Ferreira C, Galindo A, Munro S. An antibody toolkit for the study of membrane traffic in Drosophila melanogaster. Biol Open. 2016;5:987-92 pubmed publisher
Brahic M, Bousset L, Bieri G, Melki R, Gitler A. Axonal transport and secretion of fibrillar forms of α-synuclein, Aβ42 peptide and HTTExon 1. Acta Neuropathol. 2016;131:539-48 pubmed publisher
Drusenheimer N, Migdal B, Jäckel S, Tveriakhina L, Scheider K, Schulz K, et al. The Mammalian Orthologs of Drosophila Lgd, CC2D1A and CC2D1B, Function in the Endocytic Pathway, but Their Individual Loss of Function Does Not Affect Notch Signalling. PLoS Genet. 2015;11:e1005749 pubmed publisher
Cuesta Geijo M, Chiappi M, Galindo I, Barrado Gil L, Muñoz Moreno R, Carrascosa J, et al. Cholesterol Flux Is Required for Endosomal Progression of African Swine Fever Virions during the Initial Establishment of Infection. J Virol. 2016;90:1534-43 pubmed publisher
Venè R, Tosetti F, Minghelli S, Poggi A, Ferrari N, Benelli R. Celecoxib increases EGF signaling in colon tumor associated fibroblasts, modulating EGFR expression and degradation. Oncotarget. 2015;6:12310-25 pubmed
Lim J, Lachenmayer M, Wu S, Liu W, Kundu M, Wang R, et al. Proteotoxic stress induces phosphorylation of p62/SQSTM1 by ULK1 to regulate selective autophagic clearance of protein aggregates. PLoS Genet. 2015;11:e1004987 pubmed publisher
Chittoor Vinod V, Lee S, Judge S, Notterpek L. Inducible HSP70 is critical in preventing the aggregation and enhancing the processing of PMP22. ASN Neuro. 2015;7: pubmed publisher
Loskutov Y, Kozyulina P, Kozyreva V, Ice R, Jones B, Roston T, et al. NEDD9/Arf6-dependent endocytic trafficking of matrix metalloproteinase 14: a novel mechanism for blocking mesenchymal cell invasion and metastasis of breast cancer. Oncogene. 2015;34:3662-75 pubmed publisher
Corrigan L, Redhai S, Leiblich A, Fan S, Perera S, Patel R, et al. BMP-regulated exosomes from Drosophila male reproductive glands reprogram female behavior. J Cell Biol. 2014;206:671-88 pubmed publisher
Drerup C, Nechiporuk A. JNK-interacting protein 3 mediates the retrograde transport of activated c-Jun N-terminal kinase and lysosomes. PLoS Genet. 2013;9:e1003303 pubmed publisher
Fong J, Kells R, Gumpert A, Marzillier J, Davidson M, Falk M. Internalized gap junctions are degraded by autophagy. Autophagy. 2012;8:794-811 pubmed publisher
Kim C, Bergelson J. Echovirus 7 entry into polarized intestinal epithelial cells requires clathrin and Rab7. MBio. 2012;3: pubmed publisher
Feeley E, Sims J, John S, Chin C, Pertel T, Chen L, et al. IFITM3 inhibits influenza A virus infection by preventing cytosolic entry. PLoS Pathog. 2011;7:e1002337 pubmed publisher
Mateus A, Gorfinkiel N, Schamberg S, Martinez Arias A. Endocytic and recycling endosomes modulate cell shape changes and tissue behaviour during morphogenesis in Drosophila. PLoS ONE. 2011;6:e18729 pubmed publisher
Zlatic S, Tornieri K, L hernault S, Faundez V. Clathrin-dependent mechanisms modulate the subcellular distribution of class C Vps/HOPS tether subunits in polarized and nonpolarized cells. Mol Biol Cell. 2011;22:1699-715 pubmed publisher
Chinchore Y, Mitra A, Dolph P. Accumulation of rhodopsin in late endosomes triggers photoreceptor cell degeneration. PLoS Genet. 2009;5:e1000377 pubmed publisher
Pellinen T, Arjonen A, Vuoriluoto K, Kallio K, Fransen J, Ivaska J. Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins. J Cell Biol. 2006;173:767-80 pubmed
Celli J, de Chastellier C, Franchini D, Pizarro Cerda J, Moreno E, Gorvel J. Brucella evades macrophage killing via VirB-dependent sustained interactions with the endoplasmic reticulum. J Exp Med. 2003;198:545-56 pubmed
product information
Internal ID :
22688
Name :
Rab7
Depositor Name :
Munro, S.
Depositor Institution :
MRC Laboratory of Molecular Biology
Depositor Website :
http://www2.mrc-lmb.cam.ac.uk/group-leaders/h-to-m/sean-munro/
Date Deposited :
5/26/16
Allow Hybridoma Distribution :
Yes
Cells Available (legacy) :
Yes
Antigen :
RAb7/CG5915 protein
Antigen Species :
Drosophila
Host Species :
mouse
Isotype :
MIgG1, kappa light chain
Positive Tested Species Reactivity :
Drosophila
Initial Publication Pubmed ID :
27256406
Depositor Notes (Special Instructions) :
4% paraformaldehye fixation/ Antigen retrieval not required
Collections :
Drosophila antigens
Search Keywords :
Munro, S., RAb7/CG5915 protein, Drosophila, MIgG1, kappa light chain, Drosophila, Rab7, Dmel_CG5915, , Monoclonal, Drosophila antigens, Immunohistochemistry/Immunofluorescence/Western blot/Immunoprecipitation, CG5915
Antigen Molecular Weight :
23.34 kDa
Gene :
Rab7
Alternate Gene Name(s) :
Dmel_CG5915
Uniprot ID :
O76742
Antibody Registry ID :
AB_2722471
Immunogen :
Peptide conjugated to bacterial transglutaminase (BTG)
Immunogen Sequence :
amino acids 184-200 of Genbank accession NP_524472.1
Clonality :
Monoclonal
Myeloma Strain :
SP2/0-Ag14
Epitope Mapped :
Yes
Recommended Applications :
Immunofluorescence,Immunohistochemistry,Immunoprecipitation,Western Blot
Immunohistochemistry Pubmed IDs :
31344970
Depositor Growth Medium :
DMEM supplemented with 10% FCS
Additional Information :
FlyBase: FBgn0015795. RRID:AB_2722471
DSHB Growth Medium :
Iscove's
company information
Developmental Studies Hybridoma Bank
University of Iowa
http://dshb.biology.uiowa.edu
headquarters: US