catenin, beta- | Developmental Studies Hybridoma Bank PY654-B-catenin (IgG) product information

product summary

company name :

Developmental Studies Hybridoma Bank

product type :

antibody

product name :

catenin, beta-

catalog :

PY654-B-catenin (IgG)

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

PY654-B-catenin (IgG)

reactivity :

mouse, rat, chicken

application :

western blot, immunocytochemistry, immunoprecipitation

more info or order :

Developmental Studies Hybridoma Bank product webpage

citations: 5

Reference
Gallina D, Palazzo I, Steffenson L, Todd L, Fischer A. Wnt/Î²-catenin-signaling and the formation of MÃ¼ller glia-derived progenitors in the chick retina. Dev Neurobiol. 2016;76:983-1002 pubmed publisher
Soh B, Buac K, Xu H, Li E, Ng S, Wu H, et al. N-cadherin prevents the premature differentiation of anterior heart field progenitors in the pharyngeal mesodermal microenvironment. Cell Res. 2014;24:1420-32 pubmed publisher
Ulsamer A, Wei Y, Kim K, Tan K, Wheeler S, Xi Y, et al. Axin pathway activity regulates in vivo pY654-?-catenin accumulation and pulmonary fibrosis. J Biol Chem. 2012;287:5164-72 pubmed publisher
Wang T, Li Y, Chen K, Chen C, Wu C, Teng N, et al. SH2B1? regulates N-cadherin levels, cell-cell adhesion and nerve growth factor-induced neurite initiation. J Cell Physiol. 2011;226:2063-74 pubmed publisher
Rhee J, Buchan T, Zukerberg L, Lilien J, Balsamo J. Cables links Robo-bound Abl kinase to N-cadherin-bound beta-catenin to mediate Slit-induced modulation of adhesion and transcription. Nat Cell Biol. 2007;9:883-92 pubmed

product information

Internal ID :

573

Name :

PY654-B-catenin (IgG)

Depositor Name :

Balsamo, J. / Lilien, J.

Depositor Institution :

University of Iowa

Date Deposited :

6/28/07

Allow Hybridoma Distribution :

Yes

Cells Available (legacy) :

Yes

Antigen :

catenin, beta-

Antigen Species :

Mouse

Host Species :

mouse

Isotype :

MIgG1

Isotype for catalog (legacy) :

IgG1

Positive Tested Species Reactivity :

African green monkey,Chicken,Mouse,Rat

Species Tested (legacy) :

mouse, chicken, rat, African green monkey

Initial Publication Pubmed ID :

17618275

Depositor Notes (Special Instructions) :

Fusion: 09/05.

Collections :

Cell adhesion,Cell signaling,Transcription factors

Search Keywords :

Balsamo, Janne / Lilien, J., catenin, beta-, Mouse, MIgG1, Mouse/Chicken/Rat/African green monkey, Ctnnb1, Bfc; Mesc; Catnb, AB_2088265 AB_1157889, monoclonal, Cell adhesion/Cell signaling/Transcription factors, Immunofluorescence/Western Blot/Immunoprecipitation

Antigen Molecular Weight :

Predicted: 85kDa

Gene :

Ctnnb1

Alternate Gene Name(s) :

Bfc; Mesc; Catnb

Uniprot ID :

Q02248

Antibody Registry ID :

AB_2088265 AB_1157889

Immunogen :

synthetic phospho-peptide

Immunogen Sequence :

NH2-TELLHSRNEGVATpYAA-OH

Clonality :

Monoclonal

Myeloma Strain :

SP2/0

Epitope Mapped :

Yes

Epitope Location or Sequence :

NH2-TELLHSRNEGVATpYAA-OH

Epitope Map PubMed ID :

17618275

Recommended Applications :

Immunofluorescence,Immunoprecipitation,Western Blot

Immunoblotting (legacy) :

Yes

Immunofluorescence Pubmed IDs :

25367124 26663639

Western Blot Pubmed IDs :

21520058

Immunoprecipitation Pubmed IDs :

22203675

Additional Information :

This antibody is specific to beta-catenin phosphorylated at Tyr 654. Beta-1 Catenin is a Key downstream component of the canonical Wnt signaling pathway whose function is affected by differential phosphorylation. Specificity tested on Y654F beta-catenin. See mAb PY489-B-catenin for an antibody specific to beta-catenin phosphorylated at Tyr 489. The catenin target of PY489-B-catenin has been described as nuclear-bound, and the target of PY654-B-catenin (IgG) has been described as membrane-bound/cytoplasmic [PMID 25367124].

DSHB Growth Medium :

Iscove's

References (legacy) :

Nat. Cell Biol. 9(8), 883-892.; J. Cell. Physiol. 226, 2063-2074.

more info or order :

Developmental Studies Hybridoma Bank product webpage