catenin, beta- | Developmental Studies Hybridoma Bank PY489-B-catenin product information

product summary

company name :

Developmental Studies Hybridoma Bank

product type :

antibody

product name :

catenin, beta-

catalog :

PY489-B-catenin

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

PY489-B-catenin

reactivity :

mouse, chicken

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

Developmental Studies Hybridoma Bank product webpage

citations: 9

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; mouse; 1:50; loading ...; fig 7b	Chen F, Liu X, Chen Y, Liu J, Lu H, Wang W, et al. Sphere-induced reprogramming of RPE cells into dual-potential RPE stem-like cells. EBioMedicine. 2020;52:102618 pubmed publisher
	Soh B, Buac K, Xu H, Li E, Ng S, Wu H, et al. N-cadherin prevents the premature differentiation of anterior heart field progenitors in the pharyngeal mesodermal microenvironment. Cell Res. 2014;24:1420-32 pubmed publisher
	Casanova J, Travisano S, de la Pompa J. Epithelial-to-mesenchymal transition in epicardium is independent of Snail1. Genesis. 2013;51:32-40 pubmed publisher
	Kim J, Khalid O, Vo S, Sun H, Wong D, Kim Y. A novel regulatory factor recruits the nucleosome remodeling complex to wingless integrated (Wnt) signaling gene promoters in mouse embryonic stem cells. J Biol Chem. 2012;287:41103-17 pubmed publisher
	Jin Y, Han X, Taketo M, Yoon J. Wnt9b-dependent FGF signaling is crucial for outgrowth of the nasal and maxillary processes during upper jaw and lip development. Development. 2012;139:1821-30 pubmed publisher
	Nallasamy S, Li Q, Bagchi M, Bagchi I. Msx homeobox genes critically regulate embryo implantation by controlling paracrine signaling between uterine stroma and epithelium. PLoS Genet. 2012;8:e1002500 pubmed publisher
	Huang M, Sage C, Tang Y, Lee S, Petrillo M, Hinds P, et al. Overlapping and distinct pRb pathways in the mammalian auditory and vestibular organs. Cell Cycle. 2011;10:337-51 pubmed
	Song L, Li Y, Wang K, Wang Y, Molotkov A, Gao L, et al. Lrp6-mediated canonical Wnt signaling is required for lip formation and fusion. Development. 2009;136:3161-71 pubmed publisher
	Rhee J, Buchan T, Zukerberg L, Lilien J, Balsamo J. Cables links Robo-bound Abl kinase to N-cadherin-bound beta-catenin to mediate Slit-induced modulation of adhesion and transcription. Nat Cell Biol. 2007;9:883-92 pubmed

product information

Internal ID :

549

Name :

PY489-B-catenin

Depositor Name :

Balsamo, J. / Lilien, J.

Depositor Institution :

University of Iowa

Date Deposited :

6/28/07

Allow Hybridoma Distribution :

Yes

Cells Available (legacy) :

Yes

Antigen :

catenin, beta-

Antigen Species :

Mouse

Host Species :

mouse

Isotype :

MIgM

Isotype for catalog (legacy) :

IgM

Positive Tested Species Reactivity :

Chicken,Mouse

Species Tested (legacy) :

mouse, chicken

Initial Publication Pubmed ID :

17618275

Depositor Notes (Special Instructions) :

Fusion: 09/05.

Collections :

Cell adhesion,Cell signaling,Transcription factors

Search Keywords :

Balsamo, Janne / Lilien, J., catenin, beta-, Mouse, MIgM, Mouse/Chicken, Ctnnb1, Bfc; Mesc; Catnb, AB_10144551, monoclonal, Cell adhesion/Cell signaling/Transcription factors, Immunohistochemistry/Immunofluorescence/Western Blot

Antigen Molecular Weight :

Predicted: 85kDa

Gene :

Ctnnb1

Alternate Gene Name(s) :

Bfc; Mesc; Catnb

Uniprot ID :

Q02248

Antibody Registry ID :

AB_10144551

Synonyms (Alternate Clone Names) :

PY489

Immunogen :

syntetic phospho-peptide

Immunogen Sequence :

NH2-CRHQEAEMAQNAVRLHpYGL-OH

Clonality :

Monoclonal

Myeloma Strain :

SP2/0

Epitope Mapped :

Yes

Epitope Location or Sequence :

NH2-CRHQEAEMAQNAVRLHpYGL-OH

Epitope Map PubMed ID :

17618275

Recommended Applications :

Immunofluorescence,Immunohistochemistry,Western Blot

Immunoblotting (legacy) :

Yes

Immunohistochemistry Pubmed IDs :

22383889

Immunofluorescence Pubmed IDs :

17618275 25367124 23097346 19700620 22461561 21239885 23074223

Western Blot Pubmed IDs :

17618275 23074223

Additional Information :

This antibody is specific to beta-catenin phosphorylated at Tyr 489. Beta-1 Catenin is a Key downstream component of the canonical Wnt signaling pathway whose function is affected by differential phosphorylation. Specificity tested on Y489F beta-catenin. See mAb PY654-B-catenin (IgG) for an antibody specific to beta-catenin phosphorylated at Tyr 654. The catenin target of PY489-B-catenin has been described as nuclear-bound/active beta-catenin, and the target of PY654-B-catenin (IgG) has been described as membrane-bound/cytoplasmic beta-catenin.

DSHB Growth Medium :

Iscove's

References (legacy) :

Nat. Cell Biol., In Press.

more info or order :

Developmental Studies Hybridoma Bank product webpage