integrin alpha-6, avian | Developmental Studies Hybridoma Bank P2C62C4 product information

product summary

company name :

Developmental Studies Hybridoma Bank

product type :

antibody

product name :

integrin alpha-6, avian

catalog :

P2C62C4

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

P2C62C4

reactivity :

chicken

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, FACS

more info or order :

Developmental Studies Hybridoma Bank product webpage

citations: 14

Published Application/Species/Sample/Dilution	Reference
immunoprecipitation; chicken western blot; chicken	Basu S, Rajakaruna S, De Arcangelis A, Zhang L, Georges Labouesse E, Menko A. ?6 integrin transactivates insulin-like growth factor receptor-1 (IGF-1R) to regulate caspase-3-mediated lens epithelial cell differentiation initiation. J Biol Chem. 2014;289:3842-55 pubmed publisher
	Carmel M, Kahane N, Oberman F, Miloslavski R, Sela Donenfeld D, Kalcheim C, et al. A Novel Role for VICKZ Proteins in Maintaining Epithelial Integrity during Embryogenesis. PLoS ONE. 2015;10:e0136408 pubmed publisher
	Shinozuka K, Yamazaki Y, Yuguchi M, Toriumi T, Suzuki R, Tsuruga E, et al. Progressive bundling of fibrillin microfibrils into oxytalan fibers in the chick presumptive dermis. Anat Rec (Hoboken). 2013;296:71-8 pubmed publisher
	Nakaya Y, Sukowati E, Wu Y, Sheng G. RhoA and microtubule dynamics control cell-basement membrane interaction in EMT during gastrulation. Nat Cell Biol. 2008;10:765-75 pubmed publisher
	Lee S, Choi M, Lee E, Gong S, Jang M, Park S, et al. Establishment of autologous embryonic stem cells derived from preantral follicle culture and oocyte parthenogenesis. Fertil Steril. 2008;90:1910-20 pubmed
	Igyártó B, Lackó E, Oláh I, Magyar A. Characterization of chicken epidermal dendritic cells. Immunology. 2006;119:278-88 pubmed
	Strachan L, Condic M. Cranial neural crest recycle surface integrins in a substratum-dependent manner to promote rapid motility. J Cell Biol. 2004;167:545-54 pubmed
	Colas J, Schoenwolf G. Differential expression of two cell adhesion molecules, Ephrin-A5 and Integrin alpha6, during cranial neurulation in the chick embryo. Dev Neurosci. 2003;25:357-65 pubmed
	Walker J, Zhang L, Zhou J, Woolkalis M, Menko A. Role for alpha 6 integrin during lens development: Evidence for signaling through IGF-1R and ERK. Dev Dyn. 2002;223:273-84 pubmed
	Walker E, Verner A, Flannery C, Archer C. Cellular responses of embryonic hyaline cartilage to experimental wounding in vitro. J Orthop Res. 2000;18:25-34 pubmed
	Zhang Z, Galileo D. Retroviral transfer of antisense integrin alpha6 or alpha8 sequences results in laminar redistribution or clonal cell death in developing brain. J Neurosci. 1998;18:6928-38 pubmed
	Frade J, Marti E, Bovolenta P, Rodríguez Peña M, Perez Garcia D, Rohrer H, et al. Insulin-like growth factor-I stimulates neurogenesis in chick retina by regulating expression of the alpha 6 integrin subunit. Development. 1996;122:2497-506 pubmed
	Yamagata M, Herman J, Sanes J. Lamina-specific expression of adhesion molecules in developing chick optic tectum. J Neurosci. 1995;15:4556-71 pubmed
	Bronner Fraser M, Artinger M, Muschler J, Horwitz A. Developmentally regulated expression of alpha 6 integrin in avian embryos. Development. 1992;115:197-211 pubmed

product information

Internal ID :

4201

Name :

P2C62C4

Depositor Name :

Horwitz, A.F.

Depositor Institution :

University of Virginia

Date Deposited :

4/20/93

Allow Hybridoma Distribution :

Yes

Cells Available (legacy) :

Yes

Antigen :

integrin alpha-6, avian

Antigen Species :

Chicken

Host Species :

mouse

Isotype :

MIgG1, kappa light chain

Isotype for catalog (legacy) :

IgG1, kappa light chain

Positive Tested Species Reactivity :

Avian

Species Tested (legacy) :

avian

Initial Publication Pubmed ID :

1638980

Depositor Notes (Special Instructions) :

This antibody has been generated against denatured protein; it immunoblots well and immunoprecipitates the monomeric alpha subunit after the dimeric receptor has first been denatured, but doesn't precipitate the native receptor. Stains chicken embryo cryosections.

Collections :

CD antigens,Cell adhesion,Cell signaling,Extracellular matrix proteins,Neurodevelopment

Search Keywords :

Horwitz, A.F., integrin alpha-5, avian, Chicken, MIgG1, kappa light chain, Avian, ITGA6, VLA-6, AB_528301, monoclonal, Cell adhesion/Cell signaling/Cluster Determinant antigens/Neurodevelopment, Immunohistochemistry/Immunofluorescence/Western Blot/Immunoprecipitation/FACS

Antigen Molecular Weight :

Predicted: 119 kDa; Apparent: 130 kDa

Gene :

ITGA6

Alternate Gene Name(s) :

VLA-6

Uniprot ID :

P26007

Antibody Registry ID :

AB_528301

Synonyms (Alternate Clone Names) :

alpha6C6

Immunogen :

Denatured integrin alpha subunits purified from adult chicken brain tissue.

Immunogen Sequence :

Full length protein

Clonality :

Monoclonal

Myeloma Strain :

SP2/0

Epitope Mapped :

Recommended Applications :

FACS,Immunofluorescence,Immunohistochemistry,Immunoprecipitation,Western Blot

Immunoblotting (legacy) :

Yes

Immunohistochemistry Pubmed IDs :

17448472

Immunofluorescence Pubmed IDs :

1638980 15520227 18552836 10716275 9712662 16889640 7790923 23161785 1638980

Western Blot Pubmed IDs :

1638980 8756294 11836791

Immunoprecipitation Pubmed IDs :

1638980 15520227 11836791

FACS Pubmed IDs :

9712662

Pubmed IDs :

14614263

Additional Information :

P2C62C4 recognizes both uncleaved (proform) and cleaved forms of alpha-6 integrin.

DSHB Growth Medium :

Iscove's

References (legacy) :

Development 115, 197-211.; J. Cell Biol. 167(3), 545-554.; Nat. Cell Biol. 10(7), 765-775.; Trends Dev. Biol. 4, 19-32.

more info or order :

Developmental Studies Hybridoma Bank product webpage