myosin-VIIa, unconventional | Developmental Studies Hybridoma Bank MYO7A 138-1 product information

product summary

company name :

Developmental Studies Hybridoma Bank

product type :

antibody

product name :

myosin-VIIa, unconventional

catalog :

MYO7A 138-1

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

MYO7A 138-1

reactivity :

gerbils, Trachemys scripta elegans, zebra finch, human, mouse, rat, chicken, zebrafish , fruit fly

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - frozen section

more info or order :

Developmental Studies Hybridoma Bank product webpage

citations: 15

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; fruit fly; 1:100; fig 5 western blot; fruit fly; 1:10; fig 5	Li T, Giagtzoglou N, Eberl D, Jaiswal S, Cai T, Godt D, et al. The E3 ligase Ubr3 regulates Usher syndrome and MYH9 disorder proteins in the auditory organs of Drosophila and mammals. elife. 2016;5: pubmed publisher
immunocytochemistry; mouse; 1:2000	Scheffer D, Shen J, Corey D, Chen Z. Gene Expression by Mouse Inner Ear Hair Cells during Development. J Neurosci. 2015;35:6366-80 pubmed publisher
immunohistochemistry; Trachemys scripta elegans; 1:100 western blot; Trachemys scripta elegans immunohistochemistry; mouse; 1:100 immunohistochemistry; zebra finch; 1:100	Jordan P, Fettis M, Holt J. Efferent innervation of turtle semicircular canal cristae: comparisons with bird and mouse. J Comp Neurol. 2015;523:1258-80 pubmed publisher
immunohistochemistry; gerbils; 1:20 immunohistochemistry; rat; 1:20	Pujol R, Pickett S, Nguyen T, Stone J. Large basolateral processes on type II hair cells are novel processing units in mammalian vestibular organs. J Comp Neurol. 2014;522:3141-59 pubmed publisher
	Sirko P, Gale J, Ashmore J. Intercellular Ca2+ signalling in the adult mouse cochlea. J Physiol. 2019;597:303-317 pubmed publisher
	Pei W, Xu L, Huang S, Pettie K, Idol J, Rissone A, et al. Guided genetic screen to identify genes essential in the regeneration of hair cells and other tissues. NPJ Regen Med. 2018;3:11 pubmed publisher
	Breglio A, Rusheen A, Shide E, Fernandez K, Spielbauer K, McLachlin K, et al. Cisplatin is retained in the cochlea indefinitely following chemotherapy. Nat Commun. 2017;8:1654 pubmed publisher
	Pei W, Xu L, Varshney G, Carrington B, Bishop K, Jones M, et al. Additive reductions in zebrafish PRPS1 activity result in a spectrum of deficiencies modeling several human PRPS1-associated diseases. Sci Rep. 2016;6:29946 pubmed publisher
	Shin J, Krey J, Hassan A, Metlagel Z, Tauscher A, Pagana J, et al. Molecular architecture of the chick vestibular hair bundle. Nat Neurosci. 2013;16:365-74 pubmed publisher
	Yariz K, Duman D, Zazo Seco C, Dallman J, Huang M, Peters T, et al. Mutations in OTOGL, encoding the inner ear protein otogelin-like, cause moderate sensorineural hearing loss. Am J Hum Genet. 2012;91:872-82 pubmed publisher
	Burns J, Yoo J, Atala A, Jackson J. MYC gene delivery to adult mouse utricles stimulates proliferation of postmitotic supporting cells in vitro. PLoS ONE. 2012;7:e48704 pubmed publisher
	Freyer L, Aggarwal V, Morrow B. Dual embryonic origin of the mammalian otic vesicle forming the inner ear. Development. 2011;138:5403-14 pubmed publisher
	Francis S, Kramarenko I, Brandon C, Lee F, Baker T, Cunningham L. Celastrol inhibits aminoglycoside-induced ototoxicity via heat shock protein 32. Cell Death Dis. 2011;2:e195 pubmed publisher
	Demontis F, Dahmann C. Characterization of the Drosophila ortholog of the human Usher Syndrome type 1G protein sans. PLoS ONE. 2009;4:e4753 pubmed publisher
	Soni L, Warren C, Bucci C, Orten D, Hasson T. The unconventional myosin-VIIa associates with lysosomes. Cell Motil Cytoskeleton. 2005;62:13-26 pubmed

product information

Internal ID :

3933

Name :

MYO7A 138-1

Depositor Name :

Orten, D.J.

Depositor Institution :

Boys Town National Research Hospital

Date Deposited :

11/1/07

Allow Hybridoma Distribution :

Yes

Cells Available (legacy) :

Yes

Antigen :

myosin-VIIa, unconventional

Antigen Species :

Human

Host Species :

mouse

Isotype :

MIgG1, kappa light chain

Isotype for catalog (legacy) :

IgG1, kappa light chain

Positive Tested Species Reactivity :

Chicken,Human,Mouse,Rat,Zebrafish

Species Tested (legacy) :

reacts with all animals tested: human, mouse, rat, and chicken

Initial Publication Pubmed ID :

16001398

Depositor Notes (Special Instructions) :

Mutations in this antigen lead to the human condition Usher syndrome 1B.

Collections :

Cytoskeleton,Human,Skeletal muscle

Search Keywords :

Dana Jo Orten, myosin-VIIa, unconventional, Human, MIgG1, kappa light chain, human/mouse/rat/chicken, MYO7A , DFNA11, DFNB2, NSRD2, USH1B, AB_2282417, Monoclonal, Human/Cytoskeletal elements, Immunohistochemistry/Immunofluorescence/Western blot

Antigen Molecular Weight :

240 kDa

Gene :

MYO7A

Alternate Gene Name(s) :

DFNA11, DFNB2, NSRD2, USH1B

Uniprot ID :

Q13402

Antibody Registry ID :

AB_2282417

Immunogen :

Synthetic peptide

Immunogen Sequence :

a.a. 927-1203

Clonality :

Monoclonal

Myeloma Strain :

MOPC-21 NS-1

Epitope Mapped :

Yes

Epitope Location or Sequence :

a.a. 927-1203

Epitope Map PubMed ID :

16001398

Recommended Applications :

Immunofluorescence,Immunohistochemistry,Western Blot

Immunoblotting (legacy) :

Yes

Immunohistochemistry Pubmed IDs :

23119091 22110056 29162831

Immunofluorescence Pubmed IDs :

16001398 27425195 25560461 27425195 26809054

Western Blot Pubmed IDs :

16001398

Immunoprecipitation Pubmed IDs :

16001398

Additional Information :

RRID:AB_2282417

DSHB Growth Medium :

RPMI

References (legacy) :

Cell Motil. Cytoskeleton 62(1), 13-26.

more info or order :

Developmental Studies Hybridoma Bank product webpage