product summary
company name :
Developmental Studies Hybridoma Bank
product type :
antibody
product name :
Cadherin, N- (neural)
catalog :
MNCD2
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
MNCD2
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunohistochemistry - frozen section
citations: 22
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; mouse; fig 6
Li D, Sinha T, Ajima R, Seo H, Yamaguchi T, Wang J. Spatial regulation of cell cohesion by Wnt5a during second heart field progenitor deployment. Dev Biol. 2016;412:18-31 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:20; fig 1
Gonzalez J, Ramachandran J, Xie L, Contreras J, Fraidenraich D. Selective Connexin43 Inhibition Prevents Isoproterenol-Induced Arrhythmias and Lethality in Muscular Dystrophy Mice. Sci Rep. 2015;5:13490 pubmed publisher
Toro Tapia G, Villaseca S, Beyer A, Roycroft A, Marcellini S, Mayor R, et al. The Ric-8A/Gα13/FAK signalling cascade controls focal adhesion formation during neural crest cell migration in Xenopus. Development. 2018;145: pubmed publisher
Yoon J, Hwang Y, Lee M, Sun J, Cho H, Knapik L, et al. TBC1d24-ephrinB2 interaction regulates contact inhibition of locomotion in neural crest cell migration. Nat Commun. 2018;9:3491 pubmed publisher
Barriga E, Franze K, Charras G, Mayor R. Tissue stiffening coordinates morphogenesis by triggering collective cell migration in vivo. Nature. 2018;554:523-527 pubmed publisher
Cen C, Luo L, Li W, Li G, Tian N, Zheng G, et al. PKD1 Promotes Functional Synapse Formation Coordinated with N-Cadherin in Hippocampus. J Neurosci. 2018;38:183-199 pubmed publisher
Bahm I, Barriga E, Frolov A, Theveneau E, Frankel P, Mayor R. PDGF controls contact inhibition of locomotion by regulating N-cadherin during neural crest migration. Development. 2017;144:2456-2468 pubmed publisher
Wang X, Xie B, Qi Y, Wallerman O, Vasylovska S, Andersson L, et al. Knock-down of ZBED6 in insulin-producing cells promotes N-cadherin junctions between beta-cells and neural crest stem cells in vitro. Sci Rep. 2016;6:19006 pubmed publisher
Zhang Y, Fan J, Ho J, Hu T, Kneeland S, Fan X, et al. Crim1 regulates integrin signaling in murine lens development. Development. 2016;143:356-66 pubmed publisher
Klingener M, Chavali M, Singh J, McMillan N, Coomes A, Dempsey P, et al. N-cadherin promotes recruitment and migration of neural progenitor cells from the SVZ neural stem cell niche into demyelinated lesions. J Neurosci. 2014;34:9590-606 pubmed publisher
Kuriyama S, Theveneau E, Benedetto A, Parsons M, Tanaka M, Charras G, et al. In vivo collective cell migration requires an LPAR2-dependent increase in tissue fluidity. J Cell Biol. 2014;206:113-27 pubmed publisher
Hägglund A, Berghard A, Carlsson L. Canonical Wnt/?-catenin signalling is essential for optic cup formation. PLoS ONE. 2013;8:e81158 pubmed publisher
Kerosuo L, Bronner M. Biphasic influence of Miz1 on neural crest development by regulating cell survival and apical adhesion complex formation in the developing neural tube. Mol Biol Cell. 2014;25:347-55 pubmed publisher
Rogers C, Saxena A, Bronner M. Sip1 mediates an E-cadherin-to-N-cadherin switch during cranial neural crest EMT. J Cell Biol. 2013;203:835-47 pubmed publisher
Antosova B, Smolikova J, Borkovcova R, Strnad H, Lachova J, Machon O, et al. Ectopic activation of Wnt/?-catenin signaling in lens fiber cells results in cataract formation and aberrant fiber cell differentiation. PLoS ONE. 2013;8:e78279 pubmed publisher
Nakamura H, Cook R, Justice M. Mouse Tenm4 is required for mesoderm induction. BMC Dev Biol. 2013;13:9 pubmed publisher
BRUSES J. N-cadherin regulates primary motor axon growth and branching during zebrafish embryonic development. J Comp Neurol. 2011;519:1797-815 pubmed publisher
Burns J, Burns J, Christophel J, Collado M, Magnus C, Carfrae M, et al. Reinforcement of cell junctions correlates with the absence of hair cell regeneration in mammals and its occurrence in birds. J Comp Neurol. 2008;511:396-414 pubmed publisher
Jouneau A, Yu Y, Pasdar M, Larue L. Plasticity of cadherin-catenin expression in the melanocyte lineage. Pigment Cell Res. 2000;13:260-72 pubmed
Shan W, Tanaka H, Phillips G, Arndt K, Yoshida M, Colman D, et al. Functional cis-heterodimers of N- and R-cadherins. J Cell Biol. 2000;148:579-90 pubmed
Dahl U, Sjødin A, Semb H. Cadherins regulate aggregation of pancreatic beta-cells in vivo. Development. 1996;122:2895-902 pubmed
Matsunami H, Takeichi M. Fetal brain subdivisions defined by R- and E-cadherin expressions: evidence for the role of cadherin activity in region-specific, cell-cell adhesion. Dev Biol. 1995;172:466-78 pubmed
product information
Internal ID :
555
Name :
MNCD2
Depositor Name :
Takeichi, M. / Matsunami, H.
Depositor Institution :
Kyoto University
Depositor Website :
http://www.cdb.riken.jp/en/research/laboratory/takeichi.html
Date Deposited :
10/1/03
Allow Hybridoma Distribution :
Yes
Cells Available (legacy) :
Yes
Antigen :
Cadherin, N- (neural)
Antigen Species :
Mouse
Host Species :
rat
Isotype :
RIgG2a
Isotype for catalog (legacy) :
IgG2a
Positive Tested Species Reactivity :
Human,Mouse
Species Tested (legacy) :
mouse, others not tested
Initial Publication Pubmed ID :
8612964
Depositor Notes (Special Instructions) :
This antigen is also designated as CD325.
Collections :
CD antigens,Cell adhesion,Human,Neurodevelopment
Search Keywords :
Masatoshi Takeichi & Hiroaki Matsunami, Cadherin, N- (neural), Mouse, RIgG2a, Mouse/Human, Cdh2, CDHN, N-CAD, Ncad, AB_528119, Monoclonal, Human/Neurodevelopment/Cluster determinant antigens, Immunohistochemistry/Western blot
Antigen Molecular Weight :
99.76 kDa
Gene :
Cdh2
Alternate Gene Name(s) :
CDHN, N-CAD, Ncad
Uniprot ID :
P15116
Antibody Registry ID :
AB_528119
Immunogen :
Recombinant protein domain
Immunogen Sequence :
a.a. 308-597
Clonality :
Monoclonal
Myeloma Strain :
P3U1
Epitope Mapped :
No
Epitope Location or Sequence :
Extracellular domain of N-cadherin
Epitope Map PubMed ID :
8612964
Recommended Applications :
Immunohistochemistry,Western Blot
Immunohistochemistry Pubmed IDs :
8612964 24324671 23521771
Immunofluorescence Pubmed IDs :
26311238 25002680 8787762 30079980
Western Blot Pubmed IDs :
8612964 26750727 25031401 8787762 10662782
Immunoprecipitation Pubmed IDs :
8787762 10662782 10952394
Additional Information :
RRID:AB_528119
DSHB Growth Medium :
Iscove's
References (legacy) :
Dev. Biol. 172(2), 466-478.
company information
Developmental Studies Hybridoma Bank
University of Iowa
http://dshb.biology.uiowa.edu
headquarters: US