product summary
company name :
Developmental Studies Hybridoma Bank
product type :
antibody
product name :
neural retinal gangliosides (9-0-acetyl-GD3)
catalog :
JONES
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
JONES
application :
western blot, immunohistochemistry, immunocytochemistry
more info or order :
citations: 14
| Reference |
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Santiago M, Berredo Pinho M, Costa M, Gandra M, Cavalcante L, Mendez Otero R. Expression and function of ganglioside 9-O-acetyl GD3 in postmitotic granule cell development. Mol Cell Neurosci. 2001;17:488-99 pubmed
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Mendez Otero R, Cavalcante L. Expression of 9-O-acetylated gangliosides is correlated with tangential cell migration in the rat brain. Neurosci Lett. 1996;204:97-100 pubmed
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Mendez Otero R, Ramon Cueto A. Expression of 9-O-acetylated gangliosides during development of the rat olfactory system. Neuroreport. 1994;5:1755-9 pubmed
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Constantine Paton M, Blum A, Mendez Otero R, Barnstable C. A cell surface molecule distributed in a dorsoventral gradient in the perinatal rat retina. Nature. 1986;324:459-62 pubmed
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Sparrow J, Barnstable C. A gradient molecule in developing rat retina: expression of 9-O-acetyl GD3 in relation to cell type, developmental age, and GD3 ganglioside. J Neurosci Res. 1988;21:398-409 pubmed
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Bahr M, Schlosshauer B. JONES ganglioside expression on retinal glia increases after axotomy. J Neurocytol. 1989;18:553-63 pubmed
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Bonafede D, MacAla L, Constantine Paton M, Yu R. Isolation and characterization of ganglioside 9-O-acetyl-GD3 from bovine buttermilk. Lipids. 1989;24:680-4 pubmed
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Schlosshauer B, Blum A, Mendez Otero R, Barnstable C, Constantine Paton M. Developmental regulation of ganglioside antigens recognized by the JONES antibody. J Neurosci. 1988;8:580-92 pubmed
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Mendez Otero R, Schlosshauer B, Barnstable C, Constantine Paton M. A developmentally regulated antigen associated with neural cell and process migration. J Neurosci. 1988;8:564-79 pubmed
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Blum A, Barnstable C. O-acetylation of a cell-surface carbohydrate creates discrete molecular patterns during neural development. Proc Natl Acad Sci U S A. 1987;84:8716-20 pubmed
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Reinhardt Maelicke S, Cleeves V, Kindler Röhrborn A, Rajewsky M. Differential recognition of a set of O-acetylated gangliosides by monoclonal antibodies RB13-2, D1.1, and JONES during rat brain development. Brain Res Dev Brain Res. 1990;51:279-82 pubmed
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Mendez Otero R, Constantine Paton M. Granule cell induction of 9-O-acetyl gangliosides on cerebellar glia in microcultures. Dev Biol. 1990;138:400-9 pubmed
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Sjoberg E, Manzi A, Khoo K, Dell A, Varki A. Structural and immunological characterization of O-acetylated GD2. Evidence that GD2 is an acceptor for ganglioside O-acetyltransferase in human melanoma cells. J Biol Chem. 1992;267:16200-11 pubmed
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product information
Internal ID :
1798
Name :
JONES
Depositor Name :
Constantine-Paton, M.
Depositor Institution :
Massachusetts Institute of Technology
Date Deposited :
3/29/90
Allow Hybridoma Distribution :
No
Cells Available (legacy) :
No
Antigen :
neural retinal gangliosides (9-0-acetyl-GD3)
Antigen Species :
Rat
Host Species :
mouse
Isotype :
MIgM
Isotype for catalog (legacy) :
IgM
Positive Tested Species Reactivity :
Cat,Goat,Human,Monkey,Mouse,Opossum,Rat
Species Tested (legacy) :
rat, mouse, opossum, cat, goat, monkey, human
Initial Publication Pubmed ID :
3785424
Depositor Notes (Special Instructions) :
JONES doesn't react with chicken tissue. It recognizes 9-0-acetyl-GD3 and a base-labile derivative of GQ1C, present in chloroform/methanol extracts from perinatal retina; neuraminidase sensitive. By immunohistochemistry, JONES binds to aldehyde-fixed sections of late fetal and neonatal rat retina.
Collections :
Cell adhesion,Cell signaling,Extracellular matrix proteins,Human,Neurodevelopment
Search Keywords :
Constantine-Paton, M., neural retinal gangliosides (9-0-acetyl-GD3), Rat, MIgM, rat/mouse/opossum/cat/goat/monkey/human, , , AB_531870, monoclonal, Cell adhesion/Cell signaling/Human/Neurodevelopment/Extracellular matrix proteins, Immunohistochemistry/Immunofluorescence/Western Blot/Function Blocking
Antibody Registry ID :
AB_531870
Immunogen :
Retinal epithelia homogenate (lightly fixed: 2% paraformaldehyde for 30 min) of fetal rats (E13-E20)
Immunogen Sequence :
GD3
Clonality :
Monoclonal
Myeloma Strain :
P3-NS1/1-Ag4-1
Epitope Mapped :
Yes
Epitope Location or Sequence :
9-0-acetyl-GD3
Epitope Map PubMed ID :
2446330 2685488
Recommended Applications :
Function Blocking,Immunofluorescence,Immunohistochemistry,Western Blot
Immunoblotting (legacy) :
not applicable for gangliosides
Immunohistochemistry Pubmed IDs :
3216430 8929987 7827324
Immunofluorescence Pubmed IDs :
3785424 2448434 2448435 2180752 2323036 3216430 2446330 2809636 11273644 7827324
Western Blot Pubmed IDs :
3785424 1644805 2448435 2685488 2323036 2446330
Function Blocking Pubmed IDs :
11273644
Additional Information :
Gangliosides are glycosphingolipids with one or more sialic acids. Western blot references are for TLC immunooverlay.
DSHB Growth Medium :
RPMI
References (legacy) :
Nature 324, 459-462.; J. Neurosci. 8, 564-579.; J. Neurosci. 8, 580-592.; Lipids 24, 680-684.; Dev. Biol. 138, 400-409.
more info or order :
company information
Developmental Studies Hybridoma Bank
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