fibronectin, human, type III repeats 9 and 10, function blocking | Developmental Studies Hybridoma Bank HFN 7.1 product information

product summary

company name :

Developmental Studies Hybridoma Bank

product type :

antibody

product name :

fibronectin, human, type III repeats 9 and 10, function blocking

catalog :

HFN 7.1

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

HFN 7.1

reactivity :

human

application :

western blot, ELISA, immunocytochemistry

more info or order :

Developmental Studies Hybridoma Bank product webpage

citations: 15

Reference
Xing J, Ma Y, Lin M, Wang Y, Pan H, Ruan C, et al. Stretching-induced nanostructures on shape memory polyurethane films and their regulation to osteoblasts morphology. Colloids Surf B Biointerfaces. 2016;146:431-41 pubmed publisher
Fournier B, Loison Robert L, Ferré F, Owen G, Larjava H, Hakkinen L. Characterisation of human gingival neural crest-derived stem cells in monolayer and neurosphere cultures. Eur Cell Mater. 2016;31:40-58 pubmed
Singh R, Parveen M, Basgen J, Fazel S, Meshesha M, Thames E, et al. Increased Expression of Beige/Brown Adipose Markers from Host and Breast Cancer Cells Influence Xenograft Formation in Mice. Mol Cancer Res. 2016;14:78-92 pubmed publisher
Ulrich C, Quilici D, Schlauch K, Buxton I. Proteomic network analysis of human uterine smooth muscle in pregnancy, labor, and preterm labor. Integr Mol Med. 2015;2:261-269 pubmed
Mohan G, Gallant N. Surface chemistry gradients on silicone elastomers for high-throughput modulation of cell-adhesive interfaces. J Biomed Mater Res A. 2015;103:2066-76 pubmed publisher
Khalfaoui T, Groulx J, Sabra G, Guezguez A, Basora N, Vermette P, et al. Laminin receptor 37/67LR regulates adhesion and proliferation of normal human intestinal epithelial cells. PLoS ONE. 2013;8:e74337 pubmed publisher
Park J, Schwarzbauer J. Mammary epithelial cell interactions with fibronectin stimulate epithelial-mesenchymal transition. Oncogene. 2014;33:1649-57 pubmed publisher
Kong F, Garcia A, Mould A, Humphries M, Zhu C. Demonstration of catch bonds between an integrin and its ligand. J Cell Biol. 2009;185:1275-84 pubmed publisher
Graham L, Friel T, Woodman R. Fibronectin enhances Campylobacter fetus interaction with extracellular matrix components and INT 407 cells. Can J Microbiol. 2008;54:37-47 pubmed publisher
Galante L, Schwarzbauer J. Requirements for sulfate transport and the diastrophic dysplasia sulfate transporter in fibronectin matrix assembly. J Cell Biol. 2007;179:999-1009 pubmed
Bürgi Saville M, Gerber H, Peter H, Paulsson M, Aeschlimann D, Glaser C, et al. Expression patterns of extracellular matrix components in native and cultured normal human thyroid tissue and in human toxic adenoma tissue. Thyroid. 1997;7:347-56 pubmed
Harrisson F, van Nassauw L, van Hoof J, Foidart J. Microinjection of antifibronectin antibodies in the chicken blastoderm: inhibition of mesoblast cell migration but not of cell ingression at the primitive streak. Anat Rec. 1993;236:685-96 pubmed
Schoen R, Bentley K, Klebe R. Monoclonal antibody against human fibronectin which inhibits cell attachment. Hybridoma. 1982;1:99-108 pubmed
Koch G, Schoen R, Klebe R, Shows T. Assignment of a fibronection gene to human chromosome 2 using monoclonal antibodies. Exp Cell Res. 1982;141:293-302 pubmed
Bowditch R, Halloran C, Aota S, Obara M, Plow E, Yamada K, et al. Integrin alpha IIb beta 3 (platelet GPIIb-IIIa) recognizes multiple sites in fibronectin. J Biol Chem. 1991;266:23323-8 pubmed

product information

Internal ID :

2839

Name :

HFN 7.1

Depositor Name :

Klebe, R.J.

Depositor Institution :

The University of Texas Health Science Center at San Antonio

Date Deposited :

9/20/89

Allow Hybridoma Distribution :

Yes

Cells Available (legacy) :

Yes

Antigen :

fibronectin, human, type III repeats 9 and 10, function blocking

Antigen Species :

Human

Host Species :

mouse

Isotype :

MIgG1

Isotype for catalog (legacy) :

IgG1

Positive Tested Species Reactivity :

Human

Species Tested (legacy) :

human

Initial Publication Pubmed ID :

6208125

Depositor Notes (Special Instructions) :

Specific to human fibronectin. HFN 7.1 interferes with the attachment of fibronectin to its receptor on the cell surface and inhibits fibronectin mediated cell adhesion.

Collections :

Cell adhesion,Cell signaling,Extracellular matrix proteins,Human

Search Keywords :

Klebe, R.J., fibronectin, human, type III repeats 9 and 10, function blocking, Human, MIgG1, Human, FN1, FN, CIG, FNZ, MSF, ED-B, FINC, GFND, LETS, GFND2, AB_528244, monoclonal, Human/Cell adhesion/Extracellular matrix proteins/Cell signaling, Immunofluorescence/Western Blot/Function Blocking/ELISA

Antigen Molecular Weight :

Predicted: multiple isoforms between 218 and 256 kDa and one or two isoforms at 69-71 kDa, plus shorter cleavage products.

Gene :

FN1

Alternate Gene Name(s) :

FN, CIG, FNZ, MSF, ED-B, FINC, GFND, LETS, GFND2

Uniprot ID :

P02751

Antibody Registry ID :

AB_528244

Immunogen :

Human fibronectin purified from serum

Immunogen Sequence :

Full length protein

Clonality :

Monoclonal

Myeloma Strain :

P3-X63-Ag8

Epitope Mapped :

Yes

Epitope Location or Sequence :

Between the PHSRN synergy and RGD sites (spans the connection between type III repeats 9 and 10)

Epitope Map PubMed ID :

1720779

Recommended Applications :

ELISA,Function Blocking,Immunofluorescence,Western Blot

Immunofluorescence Pubmed IDs :

6208125 6183132 9226202 27395036 26728498

Western Blot Pubmed IDs :

18388970 23624917 26413312 26464213 23991217

ELISA Pubmed IDs :

6208125 6183132 25294744

Function Blocking Pubmed IDs :

6208125

Pubmed IDs :

8379592

DSHB Growth Medium :

Iscove's

References (legacy) :

Hybridoma 1, 99-108.; Anat. Rec. 236, 685-696.; Thyroid 7(3), 347-356.; Can. J. Microbiol. 54, 37-47.

more info or order :

Developmental Studies Hybridoma Bank product webpage