Carcinoembryonic antigen-related cell adhesion molecule 1; Insulin receptor kinase substrate pp120; CD66a; | Developmental Studies Hybridoma Bank HA4c19 product information

product summary

company name :

Developmental Studies Hybridoma Bank

product type :

antibody

product name :

Carcinoembryonic antigen-related cell adhesion molecule 1; Insulin receptor kinase substrate pp120; CD66a;

catalog :

HA4c19

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

HA4c19

reactivity :

mouse, rat

application :

western blot, immunocytochemistry, immunoprecipitation

more info or order :

Developmental Studies Hybridoma Bank product webpage

citations: 9

Reference
Shi G, Abbott K, Wu W, Salter R, Keyel P. Dnase1L3 Regulates Inflammasome-Dependent Cytokine Secretion. Front Immunol. 2017;8:522 pubmed publisher
Lalioti V, Peiro R, Pérez Berlanga M, Tsuchiya Y, Muñoz Á, Villalba T, et al. Basolateral sorting and transcytosis define the Cu+-regulated translocation of ATP7B to the bile canaliculus. J Cell Sci. 2016;129:2190-201 pubmed publisher
Najjar S, Yang Y, Fernstrom M, Lee S, Deangelis A, Rjaily G, et al. Insulin acutely decreases hepatic fatty acid synthase activity. Cell Metab. 2005;2:43-53 pubmed
Soni P, Lakkis M, Poy M, Fernstrom M, Najjar S. The differential effects of pp120 (Ceacam 1) on the mitogenic action of insulin and insulin-like growth factor 1 are regulated by the nonconserved tyrosine 1316 in the insulin receptor. Mol Cell Biol. 2000;20:3896-905 pubmed
Choice C, Howard M, Poy M, Hankin M, Najjar S. Insulin stimulates pp120 endocytosis in cells co-expressing insulin receptors. J Biol Chem. 1998;273:22194-200 pubmed
Najjar S, Choice C, Soni P, Whitman C, Poy M. Effect of pp120 on receptor-mediated insulin endocytosis is regulated by the juxtamembrane domain of the insulin receptor. J Biol Chem. 1998;273:12923-8 pubmed
Hubbard A, Bartles J, Braiterman L. Identification of rat hepatocyte plasma membrane proteins using monoclonal antibodies. J Cell Biol. 1985;100:1115-25 pubmed
Bartles J, Braiterman L, Hubbard A. Endogenous and exogenous domain markers of the rat hepatocyte plasma membrane. J Cell Biol. 1985;100:1126-38 pubmed
Margolis R, Taylor S, Seminara D, Hubbard A. Identification of pp120, an endogenous substrate for the hepatocyte insulin receptor tyrosine kinase, as an integral membrane glycoprotein of the bile canalicular domain. Proc Natl Acad Sci U S A. 1988;85:7256-9 pubmed

product information

Internal ID :

4219

Name :

HA4c19

Depositor Name :

Hubbard, A.

Depositor Institution :

Johns Hopkins University, Baltimore

Depositor Website :

http://www.bs.jhmi.edu/wifb/

Date Deposited :

3/24/92

Allow Hybridoma Distribution :

Yes

Cells Available (legacy) :

Yes

Antigen :

Carcinoembryonic antigen-related cell adhesion molecule 1; Insulin receptor kinase substrate pp120; CD66a;

Antigen Species :

Rat

Host Species :

mouse

Isotype :

MIgG1

Isotype for catalog (legacy) :

IgG1, kappa light chain

Positive Tested Species Reactivity :

Mouse,Rat

Species Tested (legacy) :

rat

Initial Publication Pubmed ID :

3884632

Depositor Notes (Special Instructions) :

This antibody is a cell marker for hepatocyte bile canalicular epithelial cells and is also known as billiary glycoprotein.

Collections :

CD antigens,Cell adhesion,Cell signaling

Search Keywords :

Hubbard, A, Carcinoembryonic antigen-related cell adhesion molecule 1; Insulin receptor kinase substrate pp120; CD66a; , Rat, MIgG1, Rat/Mouse, Ceacam1, BGPR, Bgp, CD66a, Ccam1, AB_10659875, Monoclonal, Cluster determinant antigens/Cell adhesion, Immunoprecipitation/Western blot/Immunofluorescence

Antigen Molecular Weight :

110-115 kDa

Gene :

Ceacam1

Alternate Gene Name(s) :

BGPR, Bgp, CD66a, Ccam1

Uniprot ID :

P16573

Antibody Registry ID :

AB_10659875

Immunogen :

Rat hepatocyte membranes

Immunogen Sequence :

Full length protein

Clonality :

Monoclonal

Myeloma Strain :

P3X63Ag8UI

Epitope Mapped :

Recommended Applications :

Immunofluorescence,Immunoprecipitation,Western Blot

Immunoblotting (legacy) :

Yes

Immunofluorescence Pubmed IDs :

9712832 16054098 27034138 3884632

Western Blot Pubmed IDs :

2845403 28533778 9582324 16054098 2984213

Immunoprecipitation Pubmed IDs :

2845403 9712832 9582324 16054098 10805733 3884632

Additional Information :

RRID:AB_10659875

DSHB Growth Medium :

Iscove's

References (legacy) :

J. Cell Biol. 100, 1115-1125.; Anat. Rec. Part A 276A, 75-102.

more info or order :

Developmental Studies Hybridoma Bank product webpage