| Published Application/Species/Sample/Dilution | Reference |
|---|
- immunocytochemistry; rat; 1:500; loading ...; fig 3g
| McMillan K, Banks P, Hellel F, Carmichael R, Clairfeuille T, Evans A, et al. Sorting nexin-27 regulates AMPA receptor trafficking through the synaptic adhesion protein LRFN2. elife. 2021;10: pubmed publisher |
- western blot; human; 1:5000
| Caballero B, Bourdenx M, Luengo E, Díaz A, Sohn P, Chen X, et al. Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice. Nat Commun. 2021;12:2238 pubmed publisher |
- immunocytochemistry; human; loading ...; fig 1a
- western blot; human; loading ...; fig 1k
| Massa L pez D, Thelen M, Stahl F, Thiel C, Linhorst A, Sylvester M, et al. The lysosomal transporter MFSD1 is essential for liver homeostasis and critically depends on its accessory subunit GLMP. elife. 2019;8: pubmed publisher |
- immunocytochemistry; human; loading ...; fig 4a
- western blot; human; loading ...; fig 4f
| Zhang X, Wang L, Ireland S, Ahat E, Li J, Bekier Ii M, et al. GORASP2/GRASP55 collaborates with the PtdIns3K UVRAG complex to facilitate autophagosome-lysosome fusion. Autophagy. 2019;:1-14 pubmed publisher |
- western blot; human; loading ...; fig 7a
| White E, Gyulay G, Lhotak S, Szewczyk M, Chong T, Fuller M, et al. Sialidase down-regulation reduces non-HDL cholesterol, inhibits leukocyte transmigration, and attenuates atherosclerosis in ApoE knockout mice. J Biol Chem. 2018;293:14689-14706 pubmed publisher |
- immunocytochemistry; human; 1:100; loading ...; fig 1a
| Jimenez Orgaz A, Kvainickas A, Nägele H, Denner J, Eimer S, Dengjel J, et al. Control of RAB7 activity and localization through the retromer-TBC1D5 complex enables RAB7-dependent mitophagy. EMBO J. 2018;37:235-254 pubmed publisher |
- immunocytochemistry; human; 1:200; fig 3b
| Aguisanda F, Yeh C, Chen C, Li R, Beers J, Zou J, et al. Neural stem cells for disease modeling of Wolman disease and evaluation of therapeutics. Orphanet J Rare Dis. 2017;12:120 pubmed publisher |
- immunocytochemistry; human; loading ...; fig 2a
| Serrano D, Ghobadi F, Boulay G, Ilangumaran S, Lavoie C, Ramanathan S. GTPase of the Immune-Associated Nucleotide Protein 5 Regulates the Lysosomal Calcium Compartment in T Lymphocytes. Front Immunol. 2017;8:94 pubmed publisher |
- immunocytochemistry; human; 1:500; loading ...; fig s1
- western blot; human; loading ...; fig 3c
| Petersen W, Stenzel W, Silvie O, Blanz J, Saftig P, Matuschewski K, et al. Sequestration of cholesterol within the host late endocytic pathway restricts liver-stage Plasmodium development. Mol Biol Cell. 2017;28:726-735 pubmed publisher |
- western blot; human; loading ...; fig 1a
| Nascimbeni A, Fanin M, Angelini C, Sandri M. Autophagy dysregulation in Danon disease. Cell Death Dis. 2017;8:e2565 pubmed publisher |
- western blot; human; loading ...; fig 6b
| Cianciola N, Chung S, Manor D, Carlin C. Adenovirus Modulates Toll-Like Receptor 4 Signaling by Reprogramming ORP1L-VAP Protein Contacts for Cholesterol Transport from Endosomes to the Endoplasmic Reticulum. J Virol. 2017;91: pubmed publisher |
- immunocytochemistry; human; loading ...; fig 3d
| Kondo H, Maksimova N, Otomo T, Kato H, Imai A, Asano Y, et al. Mutation in VPS33A affects metabolism of glycosaminoglycans: a new type of mucopolysaccharidosis with severe systemic symptoms. Hum Mol Genet. 2017;26:173-183 pubmed publisher |
- immunocytochemistry; human; 1:200; loading ...; fig 5c
| Wymant J, Hiscox S, Westwell A, Urbé S, Clague M, Jones A. The Role of BCA2 in the Endocytic Trafficking of EGFR and Significance as a Prognostic Biomarker in Cancer. J Cancer. 2016;7:2388-2407 pubmed |
- western blot; human; loading ...; fig 1c
| Shi B, Huang Q, Birkett R, Doyle R, Dorfleutner A, Stehlik C, et al. SNAPIN is critical for lysosomal acidification and autophagosome maturation in macrophages. Autophagy. 2017;13:285-301 pubmed publisher |
- immunocytochemistry; mouse; loading ...; fig 2d
| Hubert V, Peschel A, Langer B, Groger M, Rees A, Kain R. LAMP-2 is required for incorporating syntaxin-17 into autophagosomes and for their fusion with lysosomes. Biol Open. 2016;5:1516-1529 pubmed publisher |
- immunocytochemistry; human; fig 1
| Corcelle Termeau E, Vindeløv S, Hämälistö S, Mograbi B, Keldsbo A, Bräsen J, et al. Excess sphingomyelin disturbs ATG9A trafficking and autophagosome closure. Autophagy. 2016;12:833-49 pubmed publisher |
- immunocytochemistry; human; 1 ug/ml; loading ...; fig 2a
| Hale C, Cheng Q, Ortuno D, Huang M, Nojima D, Kassner P, et al. Identification of modulators of autophagic flux in an image-based high content siRNA screen. Autophagy. 2016;12:713-26 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:1000; loading ...; tbl 1
| Ito M, Nakamura K, Mori F, Miki Y, Tanji K, Wakabayashi K. Novel eosinophilic neuronal cytoplasmic inclusions in the external cuneate nucleus of humans. Neuropathology. 2016;36:441-447 pubmed publisher |
- immunocytochemistry; human; 1:200; loading ...; fig s7c
| Demetriades C, Plescher M, Teleman A. Lysosomal recruitment of TSC2 is a universal response to cellular stress. Nat Commun. 2016;7:10662 pubmed publisher |
- western blot; human; loading ...; fig 6a
| Pérez L, McLetchie S, Gardiner G, Deffit S, Zhou D, Blum J. LAMP-2C Inhibits MHC Class II Presentation of Cytoplasmic Antigens by Disrupting Chaperone-Mediated Autophagy. J Immunol. 2016;196:2457-65 pubmed publisher |
- immunocytochemistry; human; loading ...; fig 2c
- immunocytochemistry; mouse; loading ...; fig 2d
| Boonen M, Staudt C, Gilis F, Oorschot V, Klumperman J, Jadot M. Cathepsin D and its newly identified transport receptor SEZ6L2 can modulate neurite outgrowth. J Cell Sci. 2016;129:557-68 pubmed publisher |
- western blot; human; fig 2
| Vural A, Al Khodor S, Cheung G, Shi C, Srinivasan L, McQuiston T, et al. Activator of G-Protein Signaling 3-Induced Lysosomal Biogenesis Limits Macrophage Intracellular Bacterial Infection. J Immunol. 2016;196:846-56 pubmed publisher |
- immunocytochemistry; human; loading ...; fig 8a
| Yung C, Sha D, Li L, Chin L. Parkin Protects Against Misfolded SOD1 Toxicity by Promoting Its Aggresome Formation and Autophagic Clearance. Mol Neurobiol. 2016;53:6270-6287 pubmed publisher |
- western blot; human; fig 1
| Majumder P, Chakrabarti O. Mahogunin regulates fusion between amphisomes/MVBs and lysosomes via ubiquitination of TSG101. Cell Death Dis. 2015;6:e1970 pubmed publisher |
- immunocytochemistry; human
| Tatti M, Motta M, Scarpa S, Di Bartolomeo S, Cianfanelli V, Tartaglia M, et al. BCM-95 and (2-hydroxypropyl)-β-cyclodextrin reverse autophagy dysfunction and deplete stored lipids in Sap C-deficient fibroblasts. Hum Mol Genet. 2015;24:4198-211 pubmed publisher |
- immunocytochemistry; mouse; fig 7
| Lim J, Lachenmayer M, Wu S, Liu W, Kundu M, Wang R, et al. Proteotoxic stress induces phosphorylation of p62/SQSTM1 by ULK1 to regulate selective autophagic clearance of protein aggregates. PLoS Genet. 2015;11:e1004987 pubmed publisher |
- immunocytochemistry; human; 1:200
| Wiggins H, Wymant J, Solfa F, Hiscox S, Taylor K, Westwell A, et al. Disulfiram-induced cytotoxicity and endo-lysosomal sequestration of zinc in breast cancer cells. Biochem Pharmacol. 2015;93:332-42 pubmed publisher |
- western blot; human; fig 5
| Voss M, Künzel U, Higel F, Kuhn P, Colombo A, Fukumori A, et al. Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation. EMBO J. 2014;33:2890-905 pubmed publisher |
- western blot; human; loading ...; fig 3a
| Murphy K, Gysbers A, Abbott S, Tayebi N, Kim W, Sidransky E, et al. Reduced glucocerebrosidase is associated with increased ?-synuclein in sporadic Parkinson's disease. Brain. 2014;137:834-48 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:1000
| Kon T, Mori F, Tanji K, Miki Y, Kimura T, Wakabayashi K. Giant cell polymyositis and myocarditis associated with myasthenia gravis and thymoma. Neuropathology. 2013;33:281-7 pubmed publisher |
- other; human; loading ...; tbl 5.1
| Hu Y, Janitz M. High-throughput subcellular protein localization using transfected-cell arrays. Subcellular protein localization using cell arrays. Methods Mol Biol. 2011;706:53-72 pubmed publisher |
| Szumska J, Batool Z, Al Hashimi A, Venugopalan V, Skripnik V, Schaschke N, et al. Treatment of rat thyrocytes in vitro with cathepsin B and L inhibitors results in disruption of primary cilia leading to redistribution of the trace amine associated receptor 1 to the endoplasmic reticulum. Biochimie. 2019;166:270-285 pubmed publisher |
| Aits S. Methods to Detect Loss of Lysosomal Membrane Integrity. Methods Mol Biol. 2019;1880:315-329 pubmed publisher |
| Bekier M, Wang L, Li J, Huang H, Tang D, Zhang X, et al. Knockout of the Golgi stacking proteins GRASP55 and GRASP65 impairs Golgi structure and function. Mol Biol Cell. 2017;28:2833-2842 pubmed publisher |
| Jensen S, Petterson S, Halle B, Aaberg Jessen C, Kristensen B. Effects of the lysosomal destabilizing drug siramesine on glioblastoma in vitro and in vivo. BMC Cancer. 2017;17:178 pubmed publisher |
| Cortez C, Real F, Yoshida N. Lysosome biogenesis/scattering increases host cell susceptibility to invasion by Trypanosoma cruzi metacyclic forms and resistance to tissue culture trypomastigotes. Cell Microbiol. 2016;18:748-60 pubmed publisher |
| Gómez Grau M, Garrido E, Cozar M, Rodriguez Sureda V, DomÃnguez C, Arenas C, et al. Evaluation of Aminoglycoside and Non-Aminoglycoside Compounds for Stop-Codon Readthrough Therapy in Four Lysosomal Storage Diseases. PLoS ONE. 2015;10:e0135873 pubmed publisher |
| Kaushik S, Cuervo A. Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis. Nat Cell Biol. 2015;17:759-70 pubmed publisher |
| Waschbüsch D, Michels H, Strassheim S, Ossendorf E, Kessler D, Gloeckner C, et al. LRRK2 transport is regulated by its novel interacting partner Rab32. PLoS ONE. 2014;9:e111632 pubmed publisher |
| Valdor R, Mocholí E, Botbol Y, Guerrero Ros I, Chandra D, Koga H, et al. Chaperone-mediated autophagy regulates T cell responses through targeted degradation of negative regulators of T cell activation. Nat Immunol. 2014;15:1046-54 pubmed publisher |
| Holleman J, Marchese A. The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4. Mol Biol Cell. 2014;25:1892-904 pubmed publisher |
| Apaja P, Foo B, Okiyoneda T, Valinsky W, Barriere H, Atanasiu R, et al. Ubiquitination-dependent quality control of hERG K+ channel with acquired and inherited conformational defect at the plasma membrane. Mol Biol Cell. 2013;24:3787-804 pubmed publisher |
| Xiang Y, Zhang X, Nix D, Katoh T, Aoki K, Tiemeyer M, et al. Regulation of protein glycosylation and sorting by the Golgi matrix proteins GRASP55/65. Nat Commun. 2013;4:1659 pubmed publisher |
| Kurzawa Akanbi M, Hanson P, Blain P, Lett D, McKeith I, Chinnery P, et al. Glucocerebrosidase mutations alter the endoplasmic reticulum and lysosomes in Lewy body disease. J Neurochem. 2012;123:298-309 pubmed publisher |
| Mitsui Y, Yamada K, Hara S, Kinoshita M, Hayakawa T, Kakehi K. Comparative studies on glycoproteins expressing polylactosamine-type N-glycans in cancer cells. J Pharm Biomed Anal. 2012;70:718-26 pubmed publisher |
| Tey S, Khanna R. Autophagy mediates transporter associated with antigen processing-independent presentation of viral epitopes through MHC class I pathway. Blood. 2012;120:994-1004 pubmed publisher |
| Fong J, Kells R, Gumpert A, Marzillier J, Davidson M, Falk M. Internalized gap junctions are degraded by autophagy. Autophagy. 2012;8:794-811 pubmed publisher |
| Kim C, Bergelson J. Echovirus 7 entry into polarized intestinal epithelial cells requires clathrin and Rab7. MBio. 2012;3: pubmed publisher |
| Majer F, Vlaskova H, Krol L, Kalina T, Kubanek M, Stolnaya L, et al. Danon disease: a focus on processing of the novel LAMP2 mutation and comments on the beneficial use of peripheral white blood cells in the diagnosis of LAMP2 deficiency. Gene. 2012;498:183-95 pubmed publisher |
| Cottinet S, Bergemer Fouquet A, Toutain A, Sabourdy F, Maakaroun Vermesse Z, Levade T, et al. Danon disease: intrafamilial phenotypic variability related to a novel LAMP-2 mutation. J Inherit Metab Dis. 2011;34:515-22 pubmed publisher |
| Apaja P, Xu H, Lukacs G. Quality control for unfolded proteins at the plasma membrane. J Cell Biol. 2010;191:553-70 pubmed publisher |
| Welsch T, Younsi A, Disanza A, Rodriguez J, Cuervo A, Scita G, et al. Eps8 is recruited to lysosomes and subjected to chaperone-mediated autophagy in cancer cells. Exp Cell Res. 2010;316:1914-24 pubmed publisher |
| Diril M, Schmidt S, Krauss M, Gawlik V, Joost H, Schurmann A, et al. Lysosomal localization of GLUT8 in the testis--the EXXXLL motif of GLUT8 is sufficient for its intracellular sorting via AP1- and AP2-mediated interaction. FEBS J. 2009;276:3729-43 pubmed publisher |
| Di Blasi C, Jarre L, Blasevich F, Dassi P, Mora M. Danon disease: a novel LAMP2 mutation affecting the pre-mRNA splicing and causing aberrant transcripts and partial protein expression. Neuromuscul Disord. 2008;18:962-6 pubmed publisher |
| Roark E, Haldar K. Effects of lysosomal membrane protein depletion on the Salmonella-containing vacuole. PLoS ONE. 2008;3:e3538 pubmed publisher |
| Kain R, Exner M, Brandes R, Ziebermayr R, Cunningham D, Alderson C, et al. Molecular mimicry in pauci-immune focal necrotizing glomerulonephritis. Nat Med. 2008;14:1088-96 pubmed publisher |
| Shenoy S, Xiao K, Venkataramanan V, Snyder P, Freedman N, Weissman A. Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor. J Biol Chem. 2008;283:22166-76 pubmed publisher |
| Balreira A, Gaspar P, Caiola D, Chaves J, Beirão I, Lima J, et al. A nonsense mutation in the LIMP-2 gene associated with progressive myoclonic epilepsy and nephrotic syndrome. Hum Mol Genet. 2008;17:2238-43 pubmed publisher |
| Bampton E, Goemans C, Niranjan D, Mizushima N, Tolkovsky A. The dynamics of autophagy visualized in live cells: from autophagosome formation to fusion with endo/lysosomes. Autophagy. 2005;1:23-36 pubmed |
| Hu Y, Warnatz H, Vanhecke D, Wagner F, Fiebitz A, Thamm S, et al. Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. BMC Genomics. 2006;7:155 pubmed |
| Fanin M, Nascimbeni A, Fulizio L, Spinazzi M, Melacini P, Angelini C. Generalized lysosome-associated membrane protein-2 defect explains multisystem clinical involvement and allows leukocyte diagnostic screening in Danon disease. Am J Pathol. 2006;168:1309-20 pubmed |
| Kang P, Azad A, Torrelles J, Kaufman T, Beharka A, Tibesar E, et al. The human macrophage mannose receptor directs Mycobacterium tuberculosis lipoarabinomannan-mediated phagosome biogenesis. J Exp Med. 2005;202:987-99 pubmed |
| Künzli B, Berberat P, Zhu Z, Martignoni M, Kleeff J, Tempia Caliera A, et al. Influences of the lysosomal associated membrane proteins (Lamp-1, Lamp-2) and Mac-2 binding protein (Mac-2-BP) on the prognosis of pancreatic carcinoma. Cancer. 2002;94:228-39 pubmed |
| Nishino I, Fu J, Tanji K, Yamada T, Shimojo S, Koori T, et al. Primary LAMP-2 deficiency causes X-linked vacuolar cardiomyopathy and myopathy (Danon disease). Nature. 2000;406:906-10 pubmed |
| Rood P, Calafat J, von dem Borne A, Gerritsen W, van der Schoot C. Immortalisation of human bone marrow endothelial cells: characterisation of new cell lines. Eur J Clin Invest. 2000;30:618-29 pubmed |
| Sarafian V, Jadot M, Foidart J, Letesson J, van den Brule F, Castronovo V, et al. Expression of Lamp-1 and Lamp-2 and their interactions with galectin-3 in human tumor cells. Int J Cancer. 1998;75:105-11 pubmed |
| Marks M, Woodruff L, Ohno H, Bonifacino J. Protein targeting by tyrosine- and di-leucine-based signals: evidence for distinct saturable components. J Cell Biol. 1996;135:341-54 pubmed |
| Yamazaki T, Koo E, Selkoe D. Trafficking of cell-surface amyloid beta-protein precursor. II. Endocytosis, recycling and lysosomal targeting detected by immunolocalization. J Cell Sci. 1996;109 ( Pt 5):999-1008 pubmed |
| Mane S, Marzella L, Bainton D, Holt V, Cha Y, Hildreth J, et al. Purification and characterization of human lysosomal membrane glycoproteins. Arch Biochem Biophys. 1989;268:360-78 pubmed |
