product summary
company name :
Developmental Studies Hybridoma Bank
product type :
antibody
product name :
synuclein, alpha & beta
catalog :
H3C
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
H3C
reactivity :
common canary, fruit fly
application :
western blot, immunocytochemistry, immunoprecipitation
more info or order :
citations: 18
Published Application/Species/Sample/Dilution | Reference |
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Boassa D, Berlanga M, Yang M, Terada M, Hu J, Bushong E, et al. Mapping the subcellular distribution of ?-synuclein in neurons using genetically encoded probes for correlated light and electron microscopy: implications for Parkinson's disease pathogenesis. J Neurosci. 2013;33:2605-15 pubmed publisher
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Perrin R, Payton J, Barnett D, Wraight C, Woods W, Ye L, et al. Epitope mapping and specificity of the anti-alpha-synuclein monoclonal antibody Syn-1 in mouse brain and cultured cell lines. Neurosci Lett. 2003;349:133-5 pubmed
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Payton J, Perrin R, Clayton D, George J. Protein-protein interactions of alpha-synuclein in brain homogenates and transfected cells. Brain Res Mol Brain Res. 2001;95:138-45 pubmed
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Perrin R, Woods W, Clayton D, George J. Exposure to long chain polyunsaturated fatty acids triggers rapid multimerization of synucleins. J Biol Chem. 2001;276:41958-62 pubmed
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McLean P, Kawamata H, Hyman B. Alpha-synuclein-enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons. Neuroscience. 2001;104:901-12 pubmed
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Sharma N, Hewett J, Ozelius L, Ramesh V, McLean P, Breakefield X, et al. A close association of torsinA and alpha-synuclein in Lewy bodies: a fluorescence resonance energy transfer study. Am J Pathol. 2001;159:339-44 pubmed
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Gomez Tortosa E, Newell K, Irizarry M, Sanders J, Hyman B. alpha-Synuclein immunoreactivity in dementia with Lewy bodies: morphological staging and comparison with ubiquitin immunostaining. Acta Neuropathol. 2000;99:352-7 pubmed
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Serpell L, Berriman J, Jakes R, Goedert M, Crowther R. Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation. Proc Natl Acad Sci U S A. 2000;97:4897-902 pubmed
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Conway K, Harper J, Lansbury P. Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease. Nat Med. 1998;4:1318-20 pubmed
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Davidson W, Jonas A, Clayton D, George J. Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes. J Biol Chem. 1998;273:9443-9 pubmed
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Withers G, George J, Banker G, Clayton D. Delayed localization of synelfin (synuclein, NACP) to presynaptic terminals in cultured rat hippocampal neurons. Brain Res Dev Brain Res. 1997;99:87-94 pubmed
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George J, Jin H, Woods W, Clayton D. Characterization of a novel protein regulated during the critical period for song learning in the zebra finch. Neuron. 1995;15:361-72 pubmed
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product information
Internal ID :
8145
Name :
H3C
Depositor Name :
George, J.
Depositor Institution :
University of Illinois
Date Deposited :
2/14/12
Allow Hybridoma Distribution :
Yes
Cells Available (legacy) :
Yes
Antigen :
synuclein, alpha & beta
Antigen Species :
Canary
Host Species :
mouse
Isotype :
MIgG1
Isotype for catalog (legacy) :
IgG1
Positive Tested Species Reactivity :
Avian,Human,Mouse,Rat
Species Tested (legacy) :
canary, zebra finch, human, mouse, rat
Initial Publication Pubmed ID :
7646890
Collections :
Human,Neurodevelopment
Search Keywords :
George, J., synuclein, alpha & beta, Canary, MIgG1, avian/human/rat/mouse, SNCA, synelfin, NACP, AB_2618046, monoclonal, Human/Neurodevelopment, Immunofluorescence/Western Blot/Immunoprecipitation/FFPE
Antigen Molecular Weight :
Predicted: 15 kDa; Apparent: 19 kDa
Gene :
SNCA
Alternate Gene Name(s) :
synelfin, NACP
Uniprot ID :
Q91448
Antibody Registry ID :
AB_2618046
Synonyms (Alternate Clone Names) :
H3
Immunogen :
C-terminal of Canary synuclein cojugated to KLH
Immunogen Sequence :
peptide (C-EMPPEEEYQDYEPEA)
Clonality :
Monoclonal
Epitope Mapped :
Yes
Epitope Location or Sequence :
C-terminal (C-EMPPEEEYQDYEPEA)
Epitope Map PubMed ID :
7646890
Recommended Applications :
FFPE,Immunofluorescence,Immunoprecipitation,Western Blot
Immunoblotting (legacy) :
yes
Immunofluorescence Pubmed IDs :
7646890 9088569 11438481 26177091 22647715 23624948 11440819 10787032 29249285
Western Blot Pubmed IDs :
7646890 9088569 11687285 11553616 12946570 23392688 22647715 11440819 9545270
Immunoprecipitation Pubmed IDs :
11687285
Pubmed IDs :
10781096 9809558
DSHB Growth Medium :
Iscove's
References (legacy) :
Neuron 15, 361-372.; Brain Res. Dev. Brain Res. 99, 87-94.; Mol. Brain Res. 95, 138-145.; J. Biol. Chem. 276, 41958-41962.; Neurosci. Lett. 349(2), 133-135.
more info or order :
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Developmental Studies Hybridoma Bank
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