Costal-2 (cos) | Developmental Studies Hybridoma Bank Costal-2 (17E11) product information

product summary

company name :

Developmental Studies Hybridoma Bank

product type :

antibody

product name :

Costal-2 (cos)

catalog :

Costal-2 (17E11)

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

Costal-2 (17E11)

reactivity :

fruit fly

application :

ELISA, immunocytochemistry, immunoprecipitation

more info or order :

Developmental Studies Hybridoma Bank product webpage

citations: 7

Reference
Li T, Fan J, Blanco Sanchez B, Giagtzoglou N, Lin G, Yamamoto S, et al. Ubr3, a Novel Modulator of Hh Signaling Affects the Degradation of Costal-2 and Kif7 through Poly-ubiquitination. PLoS Genet. 2016;12:e1006054 pubmed publisher
Zadorozny E, Little J, Kalderon D. Contributions of Costal 2-Fused interactions to Hedgehog signaling in Drosophila. Development. 2015;142:931-42 pubmed publisher
Gao L, Wu L, Hou X, Zhang Q, Zhang F, Ye X, et al. Drosophila miR-932 modulates hedgehog signaling by targeting its co-receptor Brother of ihog. Dev Biol. 2013;377:166-76 pubmed publisher
Gao L, Hou X, Wu L, Zhang F, Zhang Q, Ye X, et al. Drosophila miR-960 negatively regulates Hedgehog signaling by suppressing Smoothened, Costal-2 and Fused. Cell Signal. 2013;25:1301-9 pubmed publisher
Wu L, Gao L, Hou X, Zhang Q, Li S, Yang Y, et al. Drosophila miR-5 suppresses Hedgehog signaling by directly targeting Smoothened. FEBS Lett. 2012;586:4052-60 pubmed publisher
Mistry H, Wilson B, Roberts I, O Kane C, Skeath J. Cullin-3 regulates pattern formation, external sensory organ development and cell survival during Drosophila development. Mech Dev. 2004;121:1495-507 pubmed
Lum L, Zhang C, Oh S, Mann R, von Kessler D, Taipale J, et al. Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2. Mol Cell. 2003;12:1261-74 pubmed

product information

Internal ID :

713

Name :

Costal-2 (17E11)

Depositor Name :

Beachy, P.A.

Depositor Institution :

Stanford University, Developmental Biology

Date Deposited :

10/21/03

Allow Hybridoma Distribution :

Yes

Cells Available (legacy) :

Yes

Antigen :

Costal-2 (cos)

Antigen Species :

Drosophila

Host Species :

mouse

Isotype :

MIgG2a, lambda light chain

Isotype for catalog (legacy) :

IgG2a

Positive Tested Species Reactivity :

Drosophila

Species Tested (legacy) :

Drosophila

Initial Publication Pubmed ID :

14636583

Depositor Notes (Special Instructions) :

This antibody doesn't seem to work for western blotting

Collections :

Cell signaling,Drosophila antigens

Search Keywords :

Beachy, P.A., Costal-2 (cos), drosophila, MIgG2a, lambda light chain, drosophila, cos, cos2, costa, CG1708, AB_528179, monoclonal, Cell signaling/Drosophila antigens, Immunofluorescence/Immunoprecipitation/ELISA

Antigen Molecular Weight :

Predicted: 133 kDa

Gene :

cos

Alternate Gene Name(s) :

cos2, costa, CG1708

Uniprot ID :

O16844

Antibody Registry ID :

AB_528179

Synonyms (Alternate Clone Names) :

17E11

Immunogen :

Recombinant N-terminal motor and neck domains (aa 1-640) fused in-frame with the Fc region of human IgG, expressed in CHO cells.

Immunogen Sequence :

Partial protein

Clonality :

Monoclonal

Epitope Mapped :

Yes

Epitope Location or Sequence :

N-terminal motor and neck domains (aa 1-640)

Epitope Map PubMed ID :

14636583

Recommended Applications :

ELISA,Immunofluorescence,Immunoprecipitation

Immunoblotting (legacy) :

Immunofluorescence Pubmed IDs :

23385085 27195754 25633354 15511641 23085394 23453925

Immunoprecipitation Pubmed IDs :

14636583

ELISA Pubmed IDs :

14636583

DSHB Growth Medium :

Iscove's

References (legacy) :

Mol. Cell. 12(5), 1261-1274.; Mech. Dev. 121, 1495-1507.

more info or order :

Developmental Studies Hybridoma Bank product webpage