product summary
company name :
Developmental Studies Hybridoma Bank
product type :
antibody
product name :
HNF3b / FoxA2
catalog :
4C7
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
4C7
reactivity :
mouse, rat, chicken
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation
citations: 19
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; chicken; 1:200; fig 3
Amarnath S, Agarwala S. Cell-cycle-dependent TGF?-BMP antagonism regulates neural tube closure by modulating tight junctions. J Cell Sci. 2017;130:119-131 pubmed publisher
  • immunohistochemistry; mouse; fig s1
Airik R, Schueler M, Airik M, Cho J, Ulanowicz K, Porath J, et al. SDCCAG8 Interacts with RAB Effector Proteins RABEP2 and ERC1 and Is Required for Hedgehog Signaling. PLoS ONE. 2016;11:e0156081 pubmed publisher
  • immunohistochemistry; mouse; 1:600
Jarrar W, Vauti F, Arnold H, Holz A. Generation of a Nkx2.2(Cre) knock-in mouse line: Analysis of cell lineages in the central nervous system. Differentiation. 2015;89:70-6 pubmed publisher
Wang C, Li J, Meng Q, Wang B. Three Tctn proteins are functionally conserved in the regulation of neural tube patterning and Gli3 processing but not ciliogenesis and Hedgehog signaling in the mouse. Dev Biol. 2017;430:156-165 pubmed publisher
Wang H, Matise M. Tcf7l2/Tcf4 Transcriptional Repressor Function Requires HDAC Activity in the Developing Vertebrate CNS. PLoS ONE. 2016;11:e0163267 pubmed publisher
Tuson M, He M, Anderson K. Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube. Development. 2011;138:4921-30 pubmed publisher
Wilson N, Stoeckli E. Cell type specific, traceable gene silencing for functional gene analysis during vertebrate neural development. Nucleic Acids Res. 2011;39:e133 pubmed publisher
Holz A, Kollmus H, Ryge J, Niederkofler V, Dias J, Ericson J, et al. The transcription factors Nkx2.2 and Nkx2.9 play a novel role in floor plate development and commissural axon guidance. Development. 2010;137:4249-60 pubmed publisher
Alvarez Medina R, Cayuso J, Okubo T, Takada S, Marti E. Wnt canonical pathway restricts graded Shh/Gli patterning activity through the regulation of Gli3 expression. Development. 2008;135:237-47 pubmed
Danesin C, Agius E, Escalas N, Ai X, Emerson C, Cochard P, et al. Ventral neural progenitors switch toward an oligodendroglial fate in response to increased Sonic hedgehog (Shh) activity: involvement of Sulfatase 1 in modulating Shh signaling in the ventral spinal cord. J Neurosci. 2006;26:5037-48 pubmed
Kim I, Ramakrishna S, Gusarova G, Yoder H, Costa R, Kalinichenko V. The forkhead box m1 transcription factor is essential for embryonic development of pulmonary vasculature. J Biol Chem. 2005;280:22278-86 pubmed
Jarov A, Williams K, Ling L, Koteliansky V, Duband J, Fournier Thibault C. A dual role for Sonic hedgehog in regulating adhesion and differentiation of neuroepithelial cells. Dev Biol. 2003;261:520-36 pubmed
Foucher I, Montesinos M, Volovitch M, Prochiantz A, Trembleau A. Joint regulation of the MAP1B promoter by HNF3beta/Foxa2 and Engrailed is the result of a highly conserved mechanism for direct interaction of homeoproteins and Fox transcription factors. Development. 2003;130:1867-76 pubmed
Tan Y, Adami G, Costa R. Maintaining HNF6 expression prevents AdHNF3beta-mediated decrease in hepatic levels of Glut-2 and glycogen. Hepatology. 2002;35:790-8 pubmed
van den Brink G, Hardwick J, Tytgat G, Brink M, ten Kate F, van Deventer S, et al. Sonic hedgehog regulates gastric gland morphogenesis in man and mouse. Gastroenterology. 2001;121:317-28 pubmed
Dubois L, Lecourtois M, Alexandre C, Hirst E, Vincent J. Regulated endocytic routing modulates wingless signaling in Drosophila embryos. Cell. 2001;105:613-24 pubmed
Kalinichenko V, Lim L, Shin B, Costa R. Differential expression of forkhead box transcription factors following butylated hydroxytoluene lung injury. Am J Physiol Lung Cell Mol Physiol. 2001;280:L695-704 pubmed
Rausa F, Tan Y, Zhou H, Yoo K, Stolz D, Watkins S, et al. Elevated levels of hepatocyte nuclear factor 3beta in mouse hepatocytes influence expression of genes involved in bile acid and glucose homeostasis. Mol Cell Biol. 2000;20:8264-82 pubmed
Ericson J, Morton S, Kawakami A, Roelink H, Jessell T. Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity. Cell. 1996;87:661-73 pubmed
product information
Internal ID :
2480
Name :
4C7
Depositor Name :
Jessell, T.M. / Brenner-Morton, S.
Depositor Institution :
HHMI/Columbia University
Date Deposited :
7/9/97
Allow Hybridoma Distribution :
Yes
Cells Available (legacy) :
Yes
Antigen :
HNF3b / FoxA2
Antigen Species :
Chicken
Host Species :
mouse
Isotype :
MIgG1
Isotype for catalog (legacy) :
IgG1, kappa light chain
Positive Tested Species Reactivity :
Chicken,Mouse,Rat
Species Tested (legacy) :
chick, rat, mouse
Initial Publication Pubmed ID :
8929535
Collections :
Transcription factors
Search Keywords :
Jessell, Thomas M / Brenner-Morton, Susan, HNF3b / FoxA2, Chicken, MIgG1, Chicken/Rat/Mouse, FOXA2, HNF-3BETA, AB_2278498, monoclonal
Antigen Molecular Weight :
Predicted: 47.23 kDa
Gene :
FOXA2
Alternate Gene Name(s) :
HNF-3BETA
Uniprot ID :
Q9PWP8
Antibody Registry ID :
AB_2278498
Synonyms (Alternate Clone Names) :
Fox2A
Immunogen :
Rhodopsin (1-6); recombinant.
Clonality :
Monoclonal
Myeloma Strain :
NS-1
Epitope Mapped :
No
Recommended Applications :
Function Blocking,Gel Supershift,Immunofluorescence,Immunohistochemistry,Immunoprecipitation,Western Blot
Immunohistochemistry Pubmed IDs :
16687495 15817462 11487541 18057099 21824915 27668865
Immunofluorescence Pubmed IDs :
14499657 21068056 28800946
Western Blot Pubmed IDs :
11027295
Immunoprecipitation Pubmed IDs :
11487541 15817462
Function Blocking Pubmed IDs :
12642491 11389831
Pubmed IDs :
11915024 11487541 11238010 22007132
DSHB Growth Medium :
Iscove's
References (legacy) :
Cell 87, 661-673.; J. Biol. Chem. 287(24), 20483-20489.
company information
Developmental Studies Hybridoma Bank
University of Iowa
http://dshb.biology.uiowa.edu
headquarters: US