phosphacan/protein tyrosine phosphatase - z/b | Developmental Studies Hybridoma Bank 2B49 product information

product summary

company name :

Developmental Studies Hybridoma Bank

product type :

antibody

product name :

phosphacan/protein tyrosine phosphatase - z/b

catalog :

2B49

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2B49

reactivity :

rat

application :

western blot, immunohistochemistry

more info or order :

Developmental Studies Hybridoma Bank product webpage

citations: 3

Reference
Margolis R, Rauch U, Maurel P, Margolis R. Neurocan and phosphacan: two major nervous tissue-specific chondroitin sulfate proteoglycans. Perspect Dev Neurobiol. 1996;3:273-90 pubmed
Sakurai T, Friedlander D, Grumet M. Expression of polypeptide variants of receptor-type protein tyrosine phosphatase beta: the secreted form, phosphacan, increases dramatically during embryonic development and modulates glial cell behavior in vitro. J Neurosci Res. 1996;43:694-706 pubmed
Maurel P, Rauch U, Flad M, Margolis R, Margolis R. Phosphacan, a chondroitin sulfate proteoglycan of brain that interacts with neurons and neural cell-adhesion molecules, is an extracellular variant of a receptor-type protein tyrosine phosphatase. Proc Natl Acad Sci U S A. 1994;91:2512-6 pubmed

product information

Internal ID :

3388

Name :

2B49

Depositor Name :

Margolis, R.K. / Margolis, R.U.

Depositor Institution :

New York University Medical Center, Department of Pharmacology

Date Deposited :

1/27/98

Allow Hybridoma Distribution :

Yes

Cells Available (legacy) :

Yes

Antigen :

phosphacan/protein tyrosine phosphatase - z/b

Antigen Species :

rat

Host Species :

mouse

Isotype :

MIgG1

Isotype for catalog (legacy) :

IgG1

Positive Tested Species Reactivity :

Rat

Species Tested (legacy) :

rat

Initial Publication Pubmed ID :

7511813

Depositor Notes (Special Instructions) :

For immunocytochemistry use ascites at dilutions of 1:100-1:500. However, frequently grows as solid tumors, so yield of ascites may be very small. Hybridoma supernatant is most economical for use with immunoblots.

Collections :

Cell adhesion,Enzymes,Extracellular matrix proteins,Neurodevelopment

Search Keywords :

Margolis/Margolis phosphacan/protein tyrosine phosphatase - z/b, ptprz1, monoclonal, rat, IgG1, Immunohistochemistry,Western Blot

Gene :

Ptprz1

Uniprot ID :

Q62656

Antibody Registry ID :

AB_2173126

Synonyms (Alternate Clone Names) :

protein tyrosine phosphatase - z/b

Immunogen :

PBS-soluble chondroitin sulfate proteoglycans from rat brain

Clonality :

Monoclonal

Myeloma Strain :

PAI

Epitope Mapped :

Recommended Applications :

Immunohistochemistry,Western Blot

Immunoblotting (legacy) :

yes

Pubmed IDs :

8984199 9117260

Additional Information :

Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades RRID:AB_2173126

DSHB Growth Medium :

Iscove's

References (legacy) :

Proc. Nat. Acad. Sci. U.S.A. 91, 2512-2516.; J. Neurosci. Res. 43, 694-706.; Perspect. Dev. Neurobiol. 3, 273-290.

more info or order :

Developmental Studies Hybridoma Bank product webpage