product summary
company name :
Dako
product type :
antibody
product name :
Melanosome
catalog :
M0634
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
HMB-45
reactivity :
human, mouse, dogs
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section
more info or order :
citations: 42
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; human; 1:75; loading ...
Strobel S, Machiraju D, Hülsmeyer I, Becker J, Paschen A, Jager D, et al. Expression of Potential Targets for Cell-Based Therapies on Melanoma Cells. Life (Basel). 2021;11: pubmed publisher
  • immunohistochemistry; human; 1:200; fig 2A
Geng Z, Walsh P, Truong V, Hill C, Ebeling M, Kapphahn R, et al. Generation of retinal pigmented epithelium from iPSCs derived from the conjunctiva of donors with and without age related macular degeneration. PLoS ONE. 2017;12:e0173575 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 4a
Choudhary P, Booth H, Gutteridge A, Surmacz B, Louca I, Steer J, et al. Directing Differentiation of Pluripotent Stem Cells Toward Retinal Pigment Epithelium Lineage. Stem Cells Transl Med. 2017;6:490-501 pubmed publisher
  • immunohistochemistry - paraffin section; dogs; 1:50; loading ...; fig st11
Furukawa S, Nagaike M, Ozaki K. Databases for technical aspects of immunohistochemistry. J Toxicol Pathol. 2017;30:79-107 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; tbl 1
Candanedo Gonzalez F, Ortiz Arce C, Rosales Perez S, Remirez Castellanos A, Cordova Uscanga C, Gamboa Dominguez A. Immunohistochemical features of giant cell ependymoma of the filum terminale with unusual clinical and radiological presentation. Diagn Pathol. 2017;12:7 pubmed publisher
  • immunocytochemistry; human; 1:25; loading ...; fig 1d
Choudhary P, Gutteridge A, Impey E, Storer R, Owen R, Whiting P, et al. Targeting the cAMP and Transforming Growth Factor-? Pathway Increases Proliferation to Promote Re-Epithelialization of Human Stem Cell-Derived Retinal Pigment Epithelium. Stem Cells Transl Med. 2016;5:925-37 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100
  • immunocytochemistry; human; loading ...
Ando K, Fujino N, Mitani K, Ota C, Okada Y, Kondo T, et al. Isolation of individual cellular components from lung tissues of patients with lymphangioleiomyomatosis. Am J Physiol Lung Cell Mol Physiol. 2016;310:L899-908 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; loading ...; tbl 2
Hes O, Condom Mundo E, Peckova K, Lopez J, Martinek P, Vanecek T, et al. Biphasic Squamoid Alveolar Renal Cell Carcinoma: A Distinctive Subtype of Papillary Renal Cell Carcinoma?. Am J Surg Pathol. 2016;40:664-75 pubmed publisher
  • flow cytometry; human; fig 1d
  • western blot; human; fig 3c
Perotti V, Baldassari P, Molla A, Vegetti C, Bersani I, Maurichi A, et al. NFATc2 is an intrinsic regulator of melanoma dedifferentiation. Oncogene. 2016;35:2862-72 pubmed publisher
  • immunocytochemistry; human; 1:25
Choudhary P, Dodsworth B, Sidders B, Gutteridge A, Michaelides C, Duckworth J, et al. A FOXM1 Dependent Mesenchymal-Epithelial Transition in Retinal Pigment Epithelium Cells. PLoS ONE. 2015;10:e0130379 pubmed publisher
  • immunohistochemistry; human
Kuroda N, Agatsuma Y, Tamura M, Martinek P, Hes O, Michal M. Sporadic renal hemangioblastoma with CA9, PAX2 and PAX8 expression: diagnostic pitfall in the differential diagnosis from clear cell renal cell carcinoma. Int J Clin Exp Pathol. 2015;8:2131-8 pubmed
  • immunohistochemistry - paraffin section; human; 1:50
Campbell J, Miller D, Cundiff D, Feng Q, Litofsky N. Neural stem/progenitor cells react to non-glial cns neoplasms. Springerplus. 2015;4:53 pubmed publisher
  • flow cytometry; mouse
Haggerty T, Dunn I, Rose L, Newton E, Pandolfi F, Kurnick J. Heat shock protein-90 inhibitors enhance antigen expression on melanomas and increase T cell recognition of tumor cells. PLoS ONE. 2014;9:e114506 pubmed publisher
  • immunocytochemistry; human; fig 6
Bultema J, Boyle J, Malenke P, Martin F, Dell Angelica E, Cheney R, et al. Myosin vc interacts with Rab32 and Rab38 proteins and works in the biogenesis and secretion of melanosomes. J Biol Chem. 2014;289:33513-28 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 2
  • immunohistochemistry - paraffin section; human; fig 2
Liang N, Zhang C, Dill P, Panasyuk G, Pion D, Koka V, et al. Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex. J Exp Med. 2014;211:2249-63 pubmed publisher
  • western blot; mouse; 1:500; fig 2
Booth A, Tarafder A, Hume A, Recchi C, Seabra M. A role for Na+,K+-ATPase ?1 in regulating Rab27a localisation on melanosomes. PLoS ONE. 2014;9:e102851 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:50
Gao L, Yue M, Davis J, Hyjek E, Schuger L. In pulmonary lymphangioleiomyomatosis expression of progesterone receptor is frequently higher than that of estrogen receptor. Virchows Arch. 2014;464:495-503 pubmed publisher
  • western blot; mouse; 1:1000
Nakajima H, Nagata T, Koga S, Imokawa G. Reduced glutathione disrupts the intracellular trafficking of tyrosinase and tyrosinase-related protein-1 but not dopachrome tautomerase and Pmel17 to melanosomes, which results in the attenuation of melanization. Arch Dermatol Res. 2014;306:37-49 pubmed publisher
  • immunohistochemistry - paraffin section; human
Gadiot J, Hooijkaas A, Kaiser A, Van Tinteren H, van Boven H, Blank C. Overall survival and PD-L1 expression in metastasized malignant melanoma. Cancer. 2011;117:2192-201 pubmed publisher
  • immunohistochemistry; human; 1:50; tbl 3
Chui J, Coroneo M, Tat L, Crouch R, Wakefield D, Di Girolamo N. Ophthalmic pterygium: a stem cell disorder with premalignant features. Am J Pathol. 2011;178:817-27 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100
Sellheyer K, Krahl D. Spatiotemporal expression pattern of neuroepithelial stem cell marker nestin suggests a role in dermal homeostasis, neovasculogenesis, and tumor stroma development: a study on embryonic and adult human skin. J Am Acad Dermatol. 2010;63:93-113 pubmed publisher
Ye H, Qin S, Li N, Lin M, Xu Y, Li X. A Rare Partner of TFE3 in the Xp11 Translocation Renal Cell Carcinoma: Clinicopathological Analyses and Detection of MED15-TFE3 Fusion. Biomed Res Int. 2019;2019:5974089 pubmed publisher
Bao H, Gao J, Chen Y, Altman J, Frankfurt O, Wilson A, et al. Rare myeloid sarcoma with KMT2A (MLL)-ELL fusion presenting as a vaginal wall mass. Diagn Pathol. 2019;14:26 pubmed publisher
Heitzer E, Groenewoud A, Meditz K, Lohberger B, Liegl Atzwanger B, Prokesch A, et al. Human melanoma brain metastases cell line MUG-Mel1, isolated clones and their detailed characterization. Sci Rep. 2019;9:4096 pubmed publisher
Karashima T, Kuno T, Kuroda N, Satake H, Fukata S, Chikazawa M, et al. Bilateral Xp11.2 translocation renal cell carcinoma: a case report. BMC Urol. 2018;18:106 pubmed publisher
Kriegsmann M, Kriegsmann K, Harms A, Longuespée R, Zgorzelski C, Leichsenring J, et al. Expression of HMB45, MelanA and SOX10 is rare in non-small cell lung cancer. Diagn Pathol. 2018;13:68 pubmed publisher
Kurose N, Yamashita M, Nakano M, Guo X, Shioya A, Nakada S, et al. Cytopathological findings of proliferating pilomatricoma misdiagnosed as a malignant parotid gland tumor. Diagn Pathol. 2018;13:65 pubmed publisher
Jing H, Wei H, Yuan H, Li Y, Li N, Mu D. Melanotic Xp11 translocation renal cancer: a report of a distinctive case and a review of the literature. Diagn Pathol. 2018;13:51 pubmed publisher
Werner Klein M, Scheitler S, Hoffmann M, Hodak I, Dietz K, Lehnert P, et al. Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma. Nat Commun. 2018;9:595 pubmed publisher
Xiong J, Su T, Zhu P, Ao Q, Ruan Q, Wang G. Malignant rhabdoid tumor in the renal allograft of an adult transplant recipient: a unique case of a rare tumor. Diagn Pathol. 2017;12:86 pubmed publisher
Liao A, Mittal P, Lawson D, Yang J, Szalai E, Grossniklaus H. Radiologic and Histopathologic Correlation of Different Growth Patterns of Metastatic Uveal Melanoma to the Liver. Ophthalmology. 2018;125:597-605 pubmed publisher
Duskova J, Sobek O. Assisting the neurologist in diagnosis of CNS malignancies - Current Possibilities and Limits of Cerebrospinal Fluid Cytology and Immunocytochemistry. Brain Behav. 2017;7:e00805 pubmed publisher
Perdiki M, Datseri G, Liapis G, Chondros N, Anastasiou I, Tzardi M, et al. Anastomosing hemangioma: report of two renal cases and analysis of the literature. Diagn Pathol. 2017;12:14 pubmed publisher
Yamada S, Kirishima M, Hiraki T, Higashi M, Hatanaka K, Tanimoto A. Epithelioid schwannoma of the skin displaying unique histopathological features: a teaching case giving rise to diagnostic difficulties on a morphological examination of a resected specimen, with a brief literature review. Diagn Pathol. 2017;12:11 pubmed publisher
Ambrosio A, Boyle J, Aradi A, Christian K, Di Pietro S. TPC2 controls pigmentation by regulating melanosome pH and size. Proc Natl Acad Sci U S A. 2016;113:5622-7 pubmed publisher
Wu Y, Wang T, Zhang P, Yang X, Wang J, Wang C. Extraneural hemangioblastoma of the kidney: the challenge for clinicopathological diagnosis. J Clin Pathol. 2015;68:1020-5 pubmed publisher
Fukunaga Kalabis M, Martinez G, Liu Z, Kalabis J, Mrass P, Weninger W, et al. CCN3 controls 3D spatial localization of melanocytes in the human skin through DDR1. J Cell Biol. 2006;175:563-9 pubmed
Wasmeier C, Romao M, Plowright L, Bennett D, Raposo G, Seabra M. Rab38 and Rab32 control post-Golgi trafficking of melanogenic enzymes. J Cell Biol. 2006;175:271-81 pubmed
Li S, Takeuchi F, Wang J, Fuller C, Pacheco Rodriguez G, Moss J, et al. MCP-1 overexpressed in tuberous sclerosis lesions acts as a paracrine factor for tumor development. J Exp Med. 2005;202:617-24 pubmed
Yamaguchi Y, Itami S, Watabe H, Yasumoto K, Abdel Malek Z, Kubo T, et al. Mesenchymal-epithelial interactions in the skin: increased expression of dickkopf1 by palmoplantar fibroblasts inhibits melanocyte growth and differentiation. J Cell Biol. 2004;165:275-85 pubmed
Andreola G, Rivoltini L, Castelli C, Huber V, Perego P, Deho P, et al. Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles. J Exp Med. 2002;195:1303-16 pubmed
Hume A, Collinson L, Rapak A, Gomes A, Hopkins C, Seabra M. Rab27a regulates the peripheral distribution of melanosomes in melanocytes. J Cell Biol. 2001;152:795-808 pubmed
company information
Dako
6392 Via Real
Carpinteria, CA 93013
customer.service.us@dako.com
http://www.dako.com
800-235-5763
headquarters: USA