This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Dako
product type :
antibody
product name :
Polyclonal Guinea Pig Anti-Insulin
catalog :
A0564
clonality :
polyclonal
host :
guinea pigs
conjugate :
nonconjugated
reactivity :
guinea pigs, platypus, Australian echidna, human, mouse, rat, zebrafish
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, other
citations: 69
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 2h
He W, Yuan T, Choezom D, Hunkler H, Annamalai K, Lupse B, et al. Ageing potentiates diet-induced glucose intolerance, β-cell failure and tissue inflammation through TLR4. Sci Rep. 2018;8:2767 pubmed publisher
  • immunocytochemistry; rat; 1:200; loading ...; fig 4e
  • western blot; rat; 1:2000; loading ...; fig 4b
Zhang X, Jiang S, Mitok K, Li L, Attie A, Martin T. BAIAP3, a C2 domain-containing Munc13 protein, controls the fate of dense-core vesicles in neuroendocrine cells. J Cell Biol. 2017;216:2151-2166 pubmed publisher
  • immunohistochemistry; zebrafish ; 1:300; loading ...; fig 6c
Tarifeño Saldivia E, Lavergne A, Bernard A, Padamata K, Bergemann D, Voz M, et al. Transcriptome analysis of pancreatic cells across distant species highlights novel important regulator genes. BMC Biol. 2017;15:21 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig s3g
Mosialou I, Shikhel S, Liu J, Maurizi A, Luo N, He Z, et al. MC4R-dependent suppression of appetite by bone-derived lipocalin 2. Nature. 2017;543:385-390 pubmed publisher
  • immunohistochemistry; human; 1:500; loading ...; fig s6a
  • immunocytochemistry; mouse; 1:2000; loading ...; fig 1e
  • immunohistochemistry; mouse; 1:500; loading ...; fig 5d
Li J, Casteels T, Frogne T, Ingvorsen C, Honore C, Courtney M, et al. Artemisinins Target GABAA Receptor Signaling and Impair ? Cell Identity. Cell. 2017;168:86-100.e15 pubmed publisher
  • flow cytometry; human; 1:200; loading ...; tbl 1
  • immunocytochemistry; human; 1:200; loading ...; tbl 1
Massumi M, Pourasgari F, Nalla A, Batchuluun B, Nagy K, Neely E, et al. An Abbreviated Protocol for In Vitro Generation of Functional Human Embryonic Stem Cell-Derived Beta-Like Cells. PLoS ONE. 2016;11:e0164457 pubmed publisher
  • other; mouse; 1:500; loading ...; fig 1 (A-E)"," (F-J)
Parween S, Kostromina E, Nord C, Eriksson M, Lindstrom P, Ahlgren U. Intra-islet lesions and lobular variations in ?-cell mass expansion in ob/ob mice revealed by 3D imaging of intact pancreas. Sci Rep. 2016;6:34885 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 4s2
Vernia S, Edwards Y, Han M, Cavanagh Kyros J, Barrett T, Kim J, et al. An alternative splicing program promotes adipose tissue thermogenesis. elife. 2016;5: pubmed publisher
  • immunocytochemistry; rat; loading ...; fig 4a
Hayes H, Zhang L, Becker T, Haldeman J, Stephens S, Arlotto M, et al. A Pdx-1-Regulated Soluble Factor Activates Rat and Human Islet Cell Proliferation. Mol Cell Biol. 2016;36:2918-2930 pubmed
  • immunocytochemistry; human; 1:500; loading ...; fig 9a
Duan H, Lee J, Moon S, Arora D, Li Y, Lim H, et al. Discovery, Synthesis, and Evaluation of 2,4-Diaminoquinazolines as a Novel Class of Pancreatic ?-Cell-Protective Agents against Endoplasmic Reticulum (ER) Stress. J Med Chem. 2016;59:7783-800 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 4
Cox A, Barrandon O, Cai E, Rios J, Chavez J, Bonnyman C, et al. Resolving Discrepant Findings on ANGPTL8 in ?-Cell Proliferation: A Collaborative Approach to Resolving the Betatrophin Controversy. PLoS ONE. 2016;11:e0159276 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; fig 1
Ye R, Wang M, Wang Q, Spurgin S, Wang Z, Sun K, et al. Autonomous interconversion between adult pancreatic α-cells and β-cells after differential metabolic challenges. Mol Metab. 2016;5:437-448 pubmed publisher
  • immunocytochemistry; mouse; 1:500; fig 1
Sakano D, Choi S, Kataoka M, Shiraki N, Uesugi M, Kume K, et al. Dopamine D2 Receptor-Mediated Regulation of Pancreatic ? Cell Mass. Stem Cell Reports. 2016;7:95-109 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; loading ...; fig 3a
Omori H, Ogaki S, Sakano D, Sato M, Umeda K, Takeda N, et al. Changes in expression of C2cd4c in pancreatic endocrine cells during pancreatic development. FEBS Lett. 2016;590:2584-93 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:100; fig 2
Abdel Hamid A, Firgany A. Favorable outcomes of hydroxychloroquine in insulin resistance may be accomplished by adjustment of the endothelial dysfunction as well as the skewed balance of adipokines. Acta Histochem. 2016;118:560-573 pubmed publisher
  • immunohistochemistry; human; 1:200; fig 1
Korsgren E, Korsgren O. An Apparent Deficiency of Lymphatic Capillaries in the Islets of Langerhans in the Human Pancreas. Diabetes. 2016;65:1004-8 pubmed publisher
  • immunohistochemistry; mouse; fig 1
Huang Y, Lan Q, Ponsonnet L, Blanquet M, Christofori G, Zaric J, et al. The matricellular protein CYR61 interferes with normal pancreatic islets architecture and promotes pancreatic neuroendocrine tumor progression. Oncotarget. 2016;7:1663-74 pubmed publisher
  • immunocytochemistry; mouse; 1:750; loading ...; tbl 2
Li Y, Adomat H, Guns E, Hojabrpour P, Duronio V, Curran T, et al. Identification of a Hematopoietic Cell Dedifferentiation-Inducing Factor. J Cell Physiol. 2016;231:1350-63 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:1000; fig 4
Korytnikov R, Nostro M. Generation of polyhormonal and multipotent pancreatic progenitor lineages from human pluripotent stem cells. Methods. 2016;101:56-64 pubmed publisher
  • immunohistochemistry; rat; 1:750; loading ...; fig 1c
Wiedemann T, Bielohuby M, Müller T, Bidlingmaier M, Pellegata N. Obesity in MENX Rats Is Accompanied by High Circulating Levels of Ghrelin and Improved Insulin Sensitivity. Diabetes. 2016;65:406-20 pubmed publisher
  • immunohistochemistry; mouse; fig 5a
Norlin S, Parekh V, Naredi P, Edlund H. Asna1/TRC40 Controls β-Cell Function and Endoplasmic Reticulum Homeostasis by Ensuring Retrograde Transport. Diabetes. 2016;65:110-9 pubmed publisher
  • immunohistochemistry; human; 1:200; fig 1s
Patel A, Yamashita N, Ascaño M, Bodmer D, Boehm E, Bodkin Clarke C, et al. RCAN1 links impaired neurotrophin trafficking to aberrant development of the sympathetic nervous system in Down syndrome. Nat Commun. 2015;6:10119 pubmed publisher
  • immunocytochemistry; rat; fig 4
  • immunohistochemistry - paraffin section; human; 1:1600; fig 3
Shen W, Taylor B, Jin Q, Nguyen Tran V, Meeusen S, Zhang Y, et al. Inhibition of DYRK1A and GSK3B induces human β-cell proliferation. Nat Commun. 2015;6:8372 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; fig 2e
Galloway J, Bethea M, Liu Y, Underwood R, Mobley J, Hunter C. SSBP3 Interacts With Islet-1 and Ldb1 to Impact Pancreatic β-Cell Target Genes. Mol Endocrinol. 2015;29:1774-86 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100
Moen I, Gebre M, Alonso Camino V, Chen D, Epstein D, McDonald D. Anti-metastatic action of FAK inhibitor OXA-11 in combination with VEGFR-2 signaling blockade in pancreatic neuroendocrine tumors. Clin Exp Metastasis. 2015;32:799-817 pubmed publisher
  • immunocytochemistry; human; 1:500; fig 4
  • immunocytochemistry; mouse; 1:500; fig 4
Ferdaoussi M, Dai X, Jensen M, Wang R, Peterson B, Huang C, et al. Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells. J Clin Invest. 2015;125:3847-60 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000; fig 2
Spaeth J, Hunter C, Bonatakis L, Guo M, French C, Slack I, et al. The FOXP1, FOXP2 and FOXP4 transcription factors are required for islet alpha cell proliferation and function in mice. Diabetologia. 2015;58:1836-44 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:400
Cheng Y, Su Y, Shan A, Jiang X, Ma Q, Wang W, et al. Generation and Characterization of Transgenic Mice Expressing Mouse Ins1 Promoter for Pancreatic β-Cell-Specific Gene Overexpression and Knockout. Endocrinology. 2015;156:2724-31 pubmed publisher
  • immunohistochemistry; rat; 1:150
Salvatierra C, Reis S, Pessoa A, De Souza L, Stoppiglia L, Veloso R, et al. Short-term low-protein diet during pregnancy alters islet area and protein content of phosphatidylinositol 3-kinase pathway in rats. An Acad Bras Cienc. 2015;87:1007-18 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500
Ye R, Wang M, Wang Q, Scherer P. Adiponectin-mediated antilipotoxic effects in regenerating pancreatic islets. Endocrinology. 2015;156:2019-28 pubmed publisher
  • immunocytochemistry; human; fig s3a
  • immunohistochemistry; mouse; fig 4a
Wang P, Alvarez Perez J, Felsenfeld D, Liu H, Sivendran S, Bender A, et al. A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication. Nat Med. 2015;21:383-8 pubmed publisher
  • flow cytometry; human; 1:200; fig 4
Sharivkin R, Walker M, Soen Y. Functional proteomics screen enables enrichment of distinct cell types from human pancreatic islets. PLoS ONE. 2015;10:e0115100 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:600
Reddy S, Zeng N, Al Diery H, Jung D, Yeu C, Joret M, et al. Analysis of peri-islet CD45-positive leucocytic infiltrates in long-standing type 1 diabetic patients. Diabetologia. 2015;58:1024-35 pubmed publisher
  • immunohistochemistry - paraffin section; Australian echidna; 1:50
  • immunohistochemistry - paraffin section; platypus; 1:50
He C, Myers M, Forbes B, Grützner F. Immunohistochemical analysis of pancreatic islets of platypus (Ornithorhynchus anatinus) and echidna (Tachyglossus aculeatus ssp.). J Anat. 2015;226:373-80 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500
Smid J, Faulkes S, Rudnicki M. Periostin induces pancreatic regeneration. Endocrinology. 2015;156:824-36 pubmed publisher
  • immunohistochemistry; guinea pigs; 1:200; fig s3
Li W, Cavelti Weder C, Zhang Y, Zhang Y, Clement K, Donovan S, et al. Long-term persistence and development of induced pancreatic beta cells generated by lineage conversion of acinar cells. Nat Biotechnol. 2014;32:1223-30 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; fig 7
Ye R, Holland W, Gordillo R, Wang M, Wang Q, Shao M, et al. Adiponectin is essential for lipid homeostasis and survival under insulin deficiency and promotes β-cell regeneration. elife. 2014;3: pubmed publisher
  • immunohistochemistry; mouse; fig 1
Kim Muller J, Zhao S, Srivastava S, Mugabo Y, Noh H, Kim Y, et al. Metabolic inflexibility impairs insulin secretion and results in MODY-like diabetes in triple FoxO-deficient mice. Cell Metab. 2014;20:593-602 pubmed publisher
  • immunocytochemistry; zebrafish ; 1:400
Huang W, Wang G, Delaspre F, Vitery M, Beer R, Parsons M. Retinoic acid plays an evolutionarily conserved and biphasic role in pancreas development. Dev Biol. 2014;394:83-93 pubmed publisher
  • immunohistochemistry - paraffin section; human
Arif S, Leete P, Nguyen V, Marks K, Nor N, Estorninho M, et al. Blood and islet phenotypes indicate immunological heterogeneity in type 1 diabetes. Diabetes. 2014;63:3835-45 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:500
  • immunocytochemistry; human; 1:500
Scharfmann R, Pechberty S, Hazhouz Y, von Bülow M, Bricout Neveu E, Grenier Godard M, et al. Development of a conditionally immortalized human pancreatic ? cell line. J Clin Invest. 2014;124:2087-98 pubmed publisher
  • immunohistochemistry; human
Molina J, Rodriguez Diaz R, Fachado A, Jacques Silva M, Berggren P, Caicedo A. Control of insulin secretion by cholinergic signaling in the human pancreatic islet. Diabetes. 2014;63:2714-26 pubmed publisher
  • immunohistochemistry - paraffin section; human
Ye J, Vives Pi M, Gillespie K. Maternal microchimerism: increased in the insulin positive compartment of type 1 diabetes pancreas but not in infiltrating immune cells or replicating islet cells. PLoS ONE. 2014;9:e86985 pubmed publisher
  • immunohistochemistry; rat; fig 1
dos Santos D, Cupertino M, Fialho M, Barbosa A, Fonseca C, Sartori S, et al. Quantification of endocrine cells and ultrastructural study of insulin granules in the large intestine of opossum Didelphis aurita (Wied-Neuwied, 1826). Tissue Cell. 2014;46:70-7 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:2000
Chen Z, Morris D, Jiang L, Liu Y, Rui L. SH2B1 in ?-cells regulates glucose metabolism by promoting ?-cell survival and islet expansion. Diabetes. 2014;63:585-95 pubmed publisher
  • immunohistochemistry - paraffin section; rat
  • immunohistochemistry; rat
Yi X, Pashaj A, Xia M, Moreau R. Reversal of obesity-induced hypertriglyceridemia by (R)-?-lipoic acid in ZDF (fa/fa) rats. Biochem Biophys Res Commun. 2013;439:390-5 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100
Frantz E, Crespo Mascarenhas C, Barreto Vianna A, Aguila M, Mandarim de Lacerda C. Renin-angiotensin system blockers protect pancreatic islets against diet-induced obesity and insulin resistance in mice. PLoS ONE. 2013;8:e67192 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:300
Johansson J, Mannerås Holm L, Shao R, Olsson A, Lönn M, Billig H, et al. Electrical vs manual acupuncture stimulation in a rat model of polycystic ovary syndrome: different effects on muscle and fat tissue insulin signaling. PLoS ONE. 2013;8:e54357 pubmed publisher
  • immunohistochemistry; human
Marchetti P, Lupi R, Bugliani M, Kirkpatrick C, Sebastiani G, Grieco F, et al. A local glucagon-like peptide 1 (GLP-1) system in human pancreatic islets. Diabetologia. 2012;55:3262-72 pubmed publisher
Ye R, Gordillo R, Shao M, Onodera T, Chen Z, Chen S, et al. Intracellular lipid metabolism impairs ? cell compensation during diet-induced obesity. J Clin Invest. 2018;128:1178-1189 pubmed publisher
Medina A, Parween S, Ullsten S, Vishnu N, Siu Y, Quach M, et al. Early deficits in insulin secretion, beta cell mass and islet blood perfusion precede onset of autoimmune type 1 diabetes in BioBreeding rats. Diabetologia. 2018;61:896-905 pubmed publisher
Singh S, Janjuha S, Hartmann T, Kayisoglu Ö, Konantz J, Birke S, et al. Different developmental histories of beta-cells generate functional and proliferative heterogeneity during islet growth. Nat Commun. 2017;8:664 pubmed publisher
Vierra N, Dadi P, Milian S, Dickerson M, Jordan K, Gilon P, et al. TALK-1 channels control ? cell endoplasmic reticulum Ca2+ homeostasis. Sci Signal. 2017;10: pubmed publisher
Dai C, Hang Y, Shostak A, Poffenberger G, Hart N, Prasad N, et al. Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling. J Clin Invest. 2017;127:3835-3844 pubmed publisher
Duan H, Li Y, Arora D, Xu D, Lim H, Wang W. Discovery of a Benzamide Derivative That Protects Pancreatic ?-Cells against Endoplasmic Reticulum Stress. J Med Chem. 2017;60:6191-6204 pubmed publisher
Churchill A, Gutiérrez G, Singer R, Lorberbaum D, Fischer K, Sussel L. Genetic evidence that Nkx2.2 acts primarily downstream of Neurog3 in pancreatic endocrine lineage development. elife. 2017;6: pubmed publisher
Schulz N, Liu K, Charbord J, Mattsson C, Tao L, Tworus D, et al. Critical role for adenosine receptor A2a in ?-cell proliferation. Mol Metab. 2016;5:1138-1146 pubmed publisher
Lu J, Liu K, Schulz N, Karampelias C, Charbord J, Hilding A, et al. IGFBP1 increases ?-cell regeneration by promoting ?- to ?-cell transdifferentiation. EMBO J. 2016;35:2026-44 pubmed publisher
Eter W, Parween S, Joosten L, Frielink C, Eriksson M, Brom M, et al. SPECT-OPT multimodal imaging enables accurate evaluation of radiotracers for ?-cell mass assessments. Sci Rep. 2016;6:24576 pubmed publisher
Benazra M, Lecomte M, Colace C, Müller A, Machado C, Pechberty S, et al. A human beta cell line with drug inducible excision of immortalizing transgenes. Mol Metab. 2015;4:916-25 pubmed publisher
van der Meulen T, Donaldson C, Cáceres E, Hunter A, Cowing Zitron C, Pound L, et al. Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion. Nat Med. 2015;21:769-76 pubmed publisher
Ren D, Sun J, Mao L, Ye H, Polonsky K. BH3-only molecule Bim mediates ?-cell death in IRS2 deficiency. Diabetes. 2014;63:3378-87 pubmed publisher
Cummings B, Bettaieb A, Graham J, Kim J, Ma F, Shibata N, et al. Bile-acid-mediated decrease in endoplasmic reticulum stress: a potential contributor to the metabolic benefits of ileal interposition surgery in UCD-T2DM rats. Dis Model Mech. 2013;6:443-56 pubmed publisher
Maddison L, Chen W. Nutrient excess stimulates ?-cell neogenesis in zebrafish. Diabetes. 2012;61:2517-24 pubmed
Koulmanda M, Bhasin M, AWDEH Z, Qipo A, Fan Z, Hanidziar D, et al. The role of TNF-? in mice with type 1- and 2- diabetes. PLoS ONE. 2012;7:e33254 pubmed publisher
Hoesli C, Johnson J, Piret J. Purified human pancreatic duct cell culture conditions defined by serum-free high-content growth factor screening. PLoS ONE. 2012;7:e33999 pubmed publisher
Hiltunen M, Khandelwal V, Yaluri N, Tiilikainen T, Tusa M, Koivisto H, et al. Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice. J Cell Mol Med. 2012;16:1206-22 pubmed publisher
Thatava T, Nelson T, Edukulla R, Sakuma T, Ohmine S, Tonne J, et al. Indolactam V/GLP-1-mediated differentiation of human iPS cells into glucose-responsive insulin-secreting progeny. Gene Ther. 2011;18:283-93 pubmed publisher
Bonner C, Bacon S, Concannon C, Rizvi S, Baquie M, Farrelly A, et al. INS-1 cells undergoing caspase-dependent apoptosis enhance the regenerative capacity of neighboring cells. Diabetes. 2010;59:2799-808 pubmed publisher
company information
Dako
6392 Via Real
Carpinteria, CA 93013
customer.service.us@dako.com
www.dako.com
800-235-5763
headquarters: USA