product summary
company name :
Dako
product type :
antibody
product name :
Tau
catalog :
A0024
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat, fruit fly
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - free floating section, western blot knockout validation
more info or order :
citations: 70
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; human; 1:200; fig 10f
  • western blot; human; loading ...; fig 6g
  • western blot knockout validation; mouse; loading ...; fig 6g
Ercan E, Eid S, Weber C, Kowalski A, Bichmann M, Behrendt A, et al. A validated antibody panel for the characterization of tau post-translational modifications. Mol Neurodegener. 2017;12:87 pubmed publisher
  • western blot; mouse; 1:2000; fig 2c
Wegmann S, DeVos S, Zeitler B, Marlen K, Bennett R, Pérez Rando M, et al. Persistent repression of tau in the brain using engineered zinc finger protein transcription factors. Sci Adv. 2021;7: pubmed publisher
  • western blot; human; loading ...; fig 2c
Amaral A, Perez Nievas B, Siao Tick Chong M, González Martínez A, Argente Escrig H, Rubio Guerra S, et al. Isoform-selective decrease of glycogen synthase kinase-3-beta (GSK-3β) reduces synaptic tau phosphorylation, transcellular spreading, and aggregation. iScience. 2021;24:102058 pubmed publisher
  • immunocytochemistry; human; 1:2000; loading ...
Nilsson F, Storm P, Sozzi E, Hidalgo Gil D, Birtele M, Sharma Y, et al. Single-Cell Profiling of Coding and Noncoding Genes in Human Dopamine Neuron Differentiation. Cells. 2021;10: pubmed publisher
  • western blot; mouse; loading ...; fig 2d
Bennett R, Hu M, Fernandes A, Pérez Rando M, Robbins A, Kamath T, et al. Tau reduction in aged mice does not impact Microangiopathy. Acta Neuropathol Commun. 2020;8:137 pubmed publisher
  • immunocytochemistry; rat; 1:1000; loading ...; fig 1b
Voskobiynyk Y, Roth J, Cochran J, Rush T, Carullo N, Mesina J, et al. Alzheimer's disease risk gene BIN1 induces Tau-dependent network hyperexcitability. elife. 2020;9: pubmed publisher
  • immunocytochemistry; human; 1:5000; fig 4e
Tang S, Fesharaki Zadeh A, Takahashi H, Nies S, Smith L, Luo A, et al. Fyn kinase inhibition reduces protein aggregation, increases synapse density and improves memory in transgenic and traumatic Tauopathy. Acta Neuropathol Commun. 2020;8:96 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 2a
  • western blot; mouse; loading ...; fig 2d
Wander C, Tseng J, Song S, Al Housseiny H, Tart D, Ajit A, et al. The Accumulation of Tau-Immunoreactive Hippocampal Granules and Corpora Amylacea Implicates Reactive Glia in Tau Pathogenesis during Aging. iScience. 2020;23:101255 pubmed publisher
  • western blot; mouse; 1:5000; loading ...; fig 1
He Z, McBride J, Xu H, Changolkar L, Kim S, Zhang B, et al. Transmission of tauopathy strains is independent of their isoform composition. Nat Commun. 2020;11:7 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 2s2b
  • immunocytochemistry; human; loading ...; fig 2s1c
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 2s1a, 2s2a, 4s1a
  • immunocytochemistry; mouse; loading ...; fig 2a, 2s1b
Yang D, Qu F, Cai H, Chuang C, Lim J, Jahchan N, et al. Axon-like protrusions promote small cell lung cancer migration and metastasis. elife. 2019;8: pubmed publisher
  • ELISA; human; loading ...; fig 5a
Ercan Herbst E, Ehrig J, Schöndorf D, Behrendt A, Klaus B, Gomez Ramos B, et al. A post-translational modification signature defines changes in soluble tau correlating with oligomerization in early stage Alzheimer's disease brain. Acta Neuropathol Commun. 2019;7:192 pubmed publisher
  • western blot; fruit fly ; 1:1000; loading ...; fig 2d
Berson A, Goodman L, Sartoris A, Otte C, Aykit J, Lee V, et al. Drosophila Ref1/ALYREF regulates transcription and toxicity associated with ALS/FTD disease etiologies. Acta Neuropathol Commun. 2019;7:65 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:5000; loading ...; fig 14m
Mammone T, Chidlow G, Casson R, Wood J. Improved immunohistochemical detection of phosphorylated mitogen-activated protein kinases in the injured rat optic nerve head. Histochem Cell Biol. 2019;151:435-456 pubmed publisher
  • immunohistochemistry; human; loading ...; fig 2e
Dominy S, LYNCH C, Ermini F, Benedyk M, Marczyk A, Konradi A, et al. Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors. Sci Adv. 2019;5:eaau3333 pubmed publisher
  • western blot; mouse; 1:10,000; loading ...; fig 1f
Freixo F, Martínez Delgado P, Manso Y, Sánchez Huertas C, Lacasa C, Soriano E, et al. NEK7 regulates dendrite morphogenesis in neurons via Eg5-dependent microtubule stabilization. Nat Commun. 2018;9:2330 pubmed publisher
  • immunocytochemistry; human; 1:5000; loading ...; fig 1a
  • western blot; human; 1:5000; loading ...; fig s5b
Tseng J, Xie L, Song S, Xie Y, Allen L, Ajit D, et al. The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology. Cell Rep. 2017;20:2169-2183 pubmed publisher
  • immunocytochemistry; mouse; 1:5000; fig 9b
Laporte M, Chatellard C, Vauchez V, Hemming F, Deloulme J, Vossier F, et al. Alix is required during development for normal growth of the mouse brain. Sci Rep. 2017;7:44767 pubmed publisher
  • immunohistochemistry - free floating section; mouse; loading ...; fig 1e
  • western blot; mouse; loading ...; fig 1a
Croft C, Wade M, Kurbatskaya K, Mastrandreas P, Hughes M, Phillips E, et al. Membrane association and release of wild-type and pathological tau from organotypic brain slice cultures. Cell Death Dis. 2017;8:e2671 pubmed publisher
  • western blot; human; 1:5000; fig 6a
Trzeciakiewicz H, Tseng J, Wander C, Madden V, Tripathy A, Yuan C, et al. A Dual Pathogenic Mechanism Links Tau Acetylation to Sporadic Tauopathy. Sci Rep. 2017;7:44102 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 2j
Stachowicz A, Olszanecki R, Suski M, Głombik K, Basta Kaim A, Adamek D, et al. Proteomic Analysis of Mitochondria-Enriched Fraction Isolated from the Frontal Cortex and Hippocampus of Apolipoprotein E Knockout Mice Treated with Alda-1, an Activator of Mitochondrial Aldehyde Dehydrogenase (ALDH2). Int J Mol Sci. 2017;18: pubmed publisher
  • western blot; human; 1:5000; loading ...; fig 4a
Sun W, Lee S, Huang X, Liu S, Inayathullah M, Kim K, et al. Attenuation of synaptic toxicity and MARK4/PAR1-mediated Tau phosphorylation by methylene blue for Alzheimer's disease treatment. Sci Rep. 2016;6:34784 pubmed publisher
  • western blot; human; 1:5000; loading ...; fig 7a
Karikari T, Turner A, Stass R, Lee L, Wilson B, Nagel D, et al. Expression and purification of tau protein and its frontotemporal dementia variants using a cleavable histidine tag. Protein Expr Purif. 2017;130:44-54 pubmed publisher
  • western blot; human; 1:1000; loading ...; tbl s4
Hansen S, Stummann T, Borland H, Hasholt L, Tumer Z, Nielsen J, et al. Induced pluripotent stem cell - derived neurons for the study of spinocerebellar ataxia type 3. Stem Cell Res. 2016;17:306-317 pubmed publisher
  • western blot; mouse; 1:10,000; fig 4
Tiwari S, Mizuno K, Ghosh A, Aziz W, Troakes C, Daoud J, et al. Alzheimer-related decrease in CYFIP2 links amyloid production to tau hyperphosphorylation and memory loss. Brain. 2016;139:2751-2765 pubmed
  • western blot; human; loading ...; fig 2f
  • western blot; mouse; loading ...; fig 2f
Hernandez Rapp J, Rainone S, Goupil C, Dorval V, Smith P, Saint Pierre M, et al. microRNA-132/212 deficiency enhances Aβ production and senile plaque deposition in Alzheimer's disease triple transgenic mice. Sci Rep. 2016;6:30953 pubmed publisher
  • western blot; human; loading ...; fig s7c
Lee S, Le Pichon C, Adolfsson O, Gafner V, Pihlgren M, Lin H, et al. Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement. Cell Rep. 2016;16:1690-1700 pubmed publisher
  • western blot; human; 1:5000; fig 5
Li T, Braunstein K, Zhang J, Lau A, Sibener L, Deeble C, et al. The neuritic plaque facilitates pathological conversion of tau in an Alzheimer's disease mouse model. Nat Commun. 2016;7:12082 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:3200; fig 5
Adams S, Tilton K, Kozubek J, Seshadri S, Delalle I. Subcellular Changes in Bridging Integrator 1 Protein Expression in the Cerebral Cortex During the Progression of Alzheimer Disease Pathology. J Neuropathol Exp Neurol. 2016;75:779-790 pubmed
  • western blot; mouse; 1:10,000; fig 4
  • immunohistochemistry - free floating section; human; 1:5000
  • western blot; human; 1:10,000; fig 4
Wu J, Hussaini S, Bastille I, Rodriguez G, Mrejeru A, Rilett K, et al. Neuronal activity enhances tau propagation and tau pathology in vivo. Nat Neurosci. 2016;19:1085-92 pubmed publisher
  • western blot; rat; fig 1
  • western blot; mouse; fig 1
Kim S, Choi K, Cho S, Yun S, Jeon J, Koh Y, et al. Fisetin stimulates autophagic degradation of phosphorylated tau via the activation of TFEB and Nrf2 transcription factors. Sci Rep. 2016;6:24933 pubmed publisher
  • western blot; human; 1:1000; fig 5
Yetman M, Fowler S, Jankowsky J. Humanized Tau Mice with Regionalized Amyloid Exhibit Behavioral Deficits but No Pathological Interaction. PLoS ONE. 2016;11:e0153724 pubmed publisher
  • western blot; mouse; fig 4
Yousuf M, Tan C, Torres Altoro M, Lu F, Plautz E, Zhang S, et al. Involvement of aberrant cyclin-dependent kinase 5/p25 activity in experimental traumatic brain injury. J Neurochem. 2016;138:317-27 pubmed publisher
  • western blot; mouse; fig 8
Winston C, Noël A, Neustadtl A, Parsadanian M, Barton D, Chellappa D, et al. Dendritic Spine Loss and Chronic White Matter Inflammation in a Mouse Model of Highly Repetitive Head Trauma. Am J Pathol. 2016;186:552-67 pubmed publisher
  • western blot; mouse; 1:10,000; fig 1
Sharma A, Lyashchenko A, Lu L, Nasrabady S, Elmaleh M, Mendelsohn M, et al. ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of function. Nat Commun. 2016;7:10465 pubmed publisher
  • immunohistochemistry; human; 1:500; fig 3
Bouge A, Parmentier M. Tau excess impairs mitosis and kinesin-5 function, leading to aneuploidy and cell death. Dis Model Mech. 2016;9:307-19 pubmed publisher
  • western blot; human; fig 2
Gentry E, Henderson B, Arrant A, Gearing M, Feng Y, Riddle N, et al. Rho Kinase Inhibition as a Therapeutic for Progressive Supranuclear Palsy and Corticobasal Degeneration. J Neurosci. 2016;36:1316-23 pubmed publisher
  • western blot; rat; fig 3
Chesser A, Ganeshan V, Yang J, Johnson G. Epigallocatechin-3-gallate enhances clearance of phosphorylated tau in primary neurons. Nutr Neurosci. 2016;19:21-31 pubmed publisher
Dimou E, Katsinelos T, Meisl G, Tuck B, Keeling S, Smith A, et al. Super-resolution imaging unveils the self-replication of tau aggregates upon seeding. Cell Rep. 2023;42:112725 pubmed publisher
Lopez D, Maltby C, Warming H, Divecha N, Vargas Caballero M, Coldwell M, et al. A luminescence-based reporter to study tau secretion reveals overlapping mechanisms for the release of healthy and pathological tau. Front Neurosci. 2023;17:1196007 pubmed publisher
Isei M, Girardi P, Rodwell Bullock J, Nehrke K, Johnson G. Site-specific phosphorylation of tau impacts mitochondrial biology and response to stressors. bioRxiv. 2023;: pubmed publisher
Kim Y, Siddiqui T, Blaze J, Cosacak M, Winters T, Kumar A, et al. RNA methyltransferase NSun2 deficiency promotes neurodegeneration through epitranscriptomic regulation of tau phosphorylation. Acta Neuropathol. 2023;145:29-48 pubmed publisher
Mart xed nez M xe1 rmol R, Small C, Jiang A, Palliyaguru T, Wallis T, Gormal R, et al. Fyn nanoclustering requires switching to an open conformation and is enhanced by FTLD-Tau biomolecular condensates. Mol Psychiatry. 2022;: pubmed publisher
Soutar M, Melandri D, O Callaghan B, Annuario E, Monaghan A, Welsh N, et al. Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson's disease at 16q11.2 and MAPT H1 loci. Brain. 2022;145:4349-4367 pubmed publisher
Conze C, Rierola M, Trushina N, Peters M, Janning D, Holzer M, et al. Caspase-cleaved tau is senescence-associated and induces a toxic gain of function by putting a brake on axonal transport. Mol Psychiatry. 2022;27:3010-3023 pubmed publisher
Palikaras K, Achanta K, Choi S, Akbari M, Bohr V. Alteration of mitochondrial homeostasis is an early event in a C. elegans model of human tauopathy. Aging (Albany NY). 2021;13:23876-23894 pubmed publisher
Miller L, Mukadam A, Durrant C, Vaysburd M, Katsinelos T, Tuck B, et al. Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue. Acta Neuropathol Commun. 2021;9:41 pubmed publisher
Ando K, Ferlini L, Suain V, Yilmaz Z, Mansour S, Le Ber I, et al. de novo MAPT mutation G335A causes severe brain atrophy, 3R and 4R PHF-tau pathology and early onset frontotemporal dementia. Acta Neuropathol Commun. 2020;8:94 pubmed publisher
Dobson Stone C, Hallupp M, Shahheydari H, Ragagnin A, Chatterton Z, Carew Jones F, et al. CYLD is a causative gene for frontotemporal dementia - amyotrophic lateral sclerosis. Brain. 2020;143:783-799 pubmed publisher
Marquié M, Agüero C, Amaral A, Villarejo Galende A, Ramanan P, Chong M, et al. [18F]-AV-1451 binding profile in chronic traumatic encephalopathy: a postmortem case series. Acta Neuropathol Commun. 2019;7:164 pubmed publisher
Chen J, Nathaniel D, Raghavan P, Nelson M, Tian R, Tse E, et al. Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation. J Biol Chem. 2019;294:18952-18966 pubmed publisher
Mancuso R, Fryatt G, Cleal M, Obst J, Pipi E, Monzón Sandoval J, et al. CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice. Brain. 2019;142:3243-3264 pubmed publisher
Pitera A, Asuni A, O Connor V, Deinhardt K. Pathogenic tau does not drive activation of the unfolded protein response. J Biol Chem. 2019;294:9679-9688 pubmed publisher
Ji C, Tang M, Zeidler C, Hohfeld J, Johnson G. BAG3 and SYNPO (synaptopodin) facilitate phospho-MAPT/Tau degradation via autophagy in neuronal processes. Autophagy. 2019;15:1199-1213 pubmed publisher
Paonessa F, Evans L, Solanki R, Larrieu D, Wray S, Hardy J, et al. Microtubules Deform the Nuclear Membrane and Disrupt Nucleocytoplasmic Transport in Tau-Mediated Frontotemporal Dementia. Cell Rep. 2019;26:582-593.e5 pubmed publisher
Harrison I, Whitaker R, Bertelli P, O Callaghan J, Csincsik L, Bocchetta M, et al. Optic nerve thinning and neurosensory retinal degeneration in the rTg4510 mouse model of frontotemporal dementia. Acta Neuropathol Commun. 2019;7:4 pubmed publisher
Julien C, Tomberlin C, Roberts C, Akram A, Stein G, Silverman M, et al. In vivo induction of membrane damage by β-amyloid peptide oligomers. Acta Neuropathol Commun. 2018;6:131 pubmed publisher
Cornelison G, Levy S, Jenson T, Frost B. Tau-induced nuclear envelope invagination causes a toxic accumulation of mRNA in Drosophila. Aging Cell. 2019;18:e12847 pubmed publisher
Srikanth P, Lagomarsino V, PEARSE R, Liao M, Ghosh S, Nehme R, et al. Convergence of independent DISC1 mutations on impaired neurite growth via decreased UNC5D expression. Transl Psychiatry. 2018;8:245 pubmed publisher
Beauchamp L, Chan J, Hung L, Padman B, Vella L, Liu X, et al. Ablation of tau causes an olfactory deficit in a murine model of Parkinson's disease. Acta Neuropathol Commun. 2018;6:57 pubmed publisher
Rousseaux M, Revelli J, Vázquez Vélez G, Kim J, Craigen E, Gonzales K, et al. Depleting Trim28 in adult mice is well tolerated and reduces levels of α-synuclein and tau. elife. 2018;7: pubmed publisher
Li C, Götz J. Pyk2 is a Novel Tau Tyrosine Kinase that is Regulated by the Tyrosine Kinase Fyn. J Alzheimers Dis. 2018;64:205-221 pubmed publisher
Stefanoska K, Volkerling A, Bertz J, Poljak A, Ke Y, Ittner L, et al. An N-terminal motif unique to primate tau enables differential protein-protein interactions. J Biol Chem. 2018;293:3710-3719 pubmed publisher
Biswas S, Kalil K. The Microtubule-Associated Protein Tau Mediates the Organization of Microtubules and Their Dynamic Exploration of Actin-Rich Lamellipodia and Filopodia of Cortical Growth Cones. J Neurosci. 2018;38:291-307 pubmed publisher
Dollé J, Jaye A, Anderson S, Ahmadzadeh H, Shenoy V, Smith D. Newfound sex differences in axonal structure underlie differential outcomes from in vitro traumatic axonal injury. Exp Neurol. 2018;300:121-134 pubmed publisher
Rodriguez Rodriguez P, Sandebring Matton A, Merino Serrais P, Parrado Fernandez C, Rabano A, Winblad B, et al. Tau hyperphosphorylation induces oligomeric insulin accumulation and insulin resistance in neurons. Brain. 2017;: pubmed publisher
Li C, Götz J. Somatodendritic accumulation of Tau in Alzheimer's disease is promoted by Fyn-mediated local protein translation. EMBO J. 2017;36:3120-3138 pubmed publisher
Nobuhara C, DeVos S, Commins C, Wegmann S, Moore B, Roe A, et al. Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro. Am J Pathol. 2017;187:1399-1412 pubmed publisher
Kurbatskaya K, Phillips E, Croft C, Dentoni G, Hughes M, Wade M, et al. Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer's disease brain. Acta Neuropathol Commun. 2016;4:34 pubmed publisher
Maj M, Hoermann G, Rasul S, Base W, Wagner L, Attems J. The Microtubule-Associated Protein Tau and Its Relevance for Pancreatic Beta Cells. J Diabetes Res. 2016;2016:1964634 pubmed publisher
Myeku N, CLELLAND C, Emrani S, Kukushkin N, Yu W, Goldberg A, et al. Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling. Nat Med. 2016;22:46-53 pubmed publisher
company information
Dako
6392 Via Real
Carpinteria, CA 93013
customer.service.us@dako.com
http://www.dako.com
800-235-5763
headquarters: USA