| Published Application/Species/Sample/Dilution | Reference | 
|---|
| immunocytochemistry; human; 1:200; fig 10fwestern blot; human; loading ...; fig 6gwestern blot knockout validation; mouse; loading ...; fig 6g
 | Ercan E, Eid S, Weber C, Kowalski A, Bichmann M, Behrendt A, et al . A validated antibody panel for the characterization of tau post-translational modifications. Mol Neurodegener. 2017;12:87 pubmed  publisher | 
| western blot; mouse; 1:2000; fig 2c
 | Wegmann S, DeVos S, Zeitler B, Marlen K, Bennett R, Pérez Rando M, et al . Persistent repression of tau in the brain using engineered zinc finger protein transcription factors. Sci Adv. 2021;7: pubmed  publisher | 
| western blot; human; loading ...; fig 2c
 | Amaral A, Perez Nievas B, Siao Tick Chong M, González Martínez A, Argente Escrig H, Rubio Guerra S, et al . Isoform-selective decrease of glycogen synthase kinase-3-beta (GSK-3β) reduces synaptic tau phosphorylation, transcellular spreading, and aggregation. iScience. 2021;24:102058 pubmed  publisher | 
| immunocytochemistry; human; 1:2000; loading ...
 | Nilsson F, Storm P, Sozzi E, Hidalgo Gil D, Birtele M, Sharma Y, et al . Single-Cell Profiling of Coding and Noncoding Genes in Human Dopamine Neuron Differentiation. Cells. 2021;10: pubmed  publisher | 
| western blot; mouse; loading ...; fig 2d
 | Bennett R, Hu M, Fernandes A, Pérez Rando M, Robbins A, Kamath T, et al . Tau reduction in aged mice does not impact Microangiopathy. Acta Neuropathol Commun. 2020;8:137 pubmed  publisher | 
| immunocytochemistry; rat; 1:1000; loading ...; fig 1b
 | Voskobiynyk Y, Roth J, Cochran J, Rush T, Carullo N, Mesina J, et al . Alzheimer's disease risk gene BIN1 induces Tau-dependent network hyperexcitability. elife. 2020;9: pubmed  publisher | 
| immunocytochemistry; human; 1:5000; fig 4e
 | Tang S, Fesharaki Zadeh A, Takahashi H, Nies S, Smith L, Luo A, et al . Fyn kinase inhibition reduces protein aggregation, increases synapse density and improves memory in transgenic and traumatic Tauopathy. Acta Neuropathol Commun. 2020;8:96 pubmed  publisher | 
| immunohistochemistry; mouse; loading ...; fig 2awestern blot; mouse; loading ...; fig 2d
 | Wander C, Tseng J, Song S, Al Housseiny H, Tart D, Ajit A, et al . The Accumulation of Tau-Immunoreactive Hippocampal Granules and Corpora Amylacea Implicates Reactive Glia in Tau Pathogenesis during Aging. iScience. 2020;23:101255 pubmed  publisher | 
| western blot; mouse; 1:5000; loading ...; fig 1
 | He Z, McBride J, Xu H, Changolkar L, Kim S, Zhang B, et al . Transmission of tauopathy strains is independent of their isoform composition. Nat Commun. 2020;11:7 pubmed  publisher | 
| immunohistochemistry - paraffin section; human; loading ...; fig 2s2bimmunocytochemistry; human; loading ...; fig 2s1cimmunohistochemistry - paraffin section; mouse; loading ...; fig 2s1a, 2s2a, 4s1aimmunocytochemistry; mouse; loading ...; fig 2a, 2s1b
 | Yang D, Qu F, Cai H, Chuang C, Lim J, Jahchan N, et al . Axon-like protrusions promote small cell lung cancer migration and metastasis. elife. 2019;8: pubmed  publisher | 
| ELISA; human; loading ...; fig 5a
 | Ercan Herbst E, Ehrig J, Schöndorf D, Behrendt A, Klaus B, Gomez Ramos B, et al . A post-translational modification signature defines changes in soluble tau correlating with oligomerization in early stage Alzheimer's disease brain. Acta Neuropathol Commun. 2019;7:192 pubmed  publisher | 
| western blot; fruit fly ; 1:1000; loading ...; fig 2d
 | Berson A, Goodman L, Sartoris A, Otte C, Aykit J, Lee V, et al . Drosophila Ref1/ALYREF regulates transcription and toxicity associated with ALS/FTD disease etiologies. Acta Neuropathol Commun. 2019;7:65 pubmed  publisher | 
| immunohistochemistry - paraffin section; rat; 1:5000; loading ...; fig 14m
 | Mammone T, Chidlow G, Casson R, Wood J. Improved immunohistochemical detection of phosphorylated mitogen-activated protein kinases in the injured rat optic nerve head. Histochem Cell Biol. 2019;151:435-456 pubmed  publisher | 
| immunohistochemistry; human; loading ...; fig 2e
 | Dominy S, LYNCH C, Ermini F, Benedyk M, Marczyk A, Konradi A, et al . Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors. Sci Adv. 2019;5:eaau3333 pubmed  publisher | 
| western blot; mouse; 1:10,000; loading ...; fig 1f
 | Freixo F, Martínez Delgado P, Manso Y, Sánchez Huertas C, Lacasa C, Soriano E, et al . NEK7 regulates dendrite morphogenesis in neurons via Eg5-dependent microtubule stabilization. Nat Commun. 2018;9:2330 pubmed  publisher | 
| immunocytochemistry; human; 1:5000; loading ...; fig 1awestern blot; human; 1:5000; loading ...; fig s5b
 | Tseng J, Xie L, Song S, Xie Y, Allen L, Ajit D, et al . The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology. Cell Rep. 2017;20:2169-2183 pubmed  publisher | 
| immunocytochemistry; mouse; 1:5000; fig 9b
 | Laporte M, Chatellard C, Vauchez V, Hemming F, Deloulme J, Vossier F, et al . Alix is required during development for normal growth of the mouse brain. Sci Rep. 2017;7:44767 pubmed  publisher | 
| immunohistochemistry - free floating section; mouse; loading ...; fig 1ewestern blot; mouse; loading ...; fig 1a
 | Croft C, Wade M, Kurbatskaya K, Mastrandreas P, Hughes M, Phillips E, et al . Membrane association and release of wild-type and pathological tau from organotypic brain slice cultures. Cell Death Dis. 2017;8:e2671 pubmed  publisher | 
| western blot; human; 1:5000; fig 6a
 | Trzeciakiewicz H, Tseng J, Wander C, Madden V, Tripathy A, Yuan C, et al . A Dual Pathogenic Mechanism Links Tau Acetylation to Sporadic Tauopathy. Sci Rep. 2017;7:44102 pubmed  publisher | 
| immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 2j
 | Stachowicz A, Olszanecki R, Suski M, Głombik K, Basta Kaim A, Adamek D, et al . Proteomic Analysis of Mitochondria-Enriched Fraction Isolated from the Frontal Cortex and Hippocampus of Apolipoprotein E Knockout Mice Treated with Alda-1, an Activator of Mitochondrial Aldehyde Dehydrogenase (ALDH2). Int J Mol Sci. 2017;18: pubmed  publisher | 
| western blot; human; 1:5000; loading ...; fig 4a
 | Sun W, Lee S, Huang X, Liu S, Inayathullah M, Kim K, et al . Attenuation of synaptic toxicity and MARK4/PAR1-mediated Tau phosphorylation by methylene blue for Alzheimer's disease treatment. Sci Rep. 2016;6:34784 pubmed  publisher | 
| western blot; human; 1:5000; loading ...; fig 7a
 | Karikari T, Turner A, Stass R, Lee L, Wilson B, Nagel D, et al . Expression and purification of tau protein and its frontotemporal dementia variants using a cleavable histidine tag. Protein Expr Purif. 2017;130:44-54 pubmed  publisher | 
| western blot; human; 1:1000; loading ...; tbl s4
 | Hansen S, Stummann T, Borland H, Hasholt L, Tumer Z, Nielsen J, et al . Induced pluripotent stem cell - derived neurons for the study of spinocerebellar ataxia type 3. Stem Cell Res. 2016;17:306-317 pubmed  publisher | 
| western blot; mouse; 1:10,000; fig 4
 | Tiwari S, Mizuno K, Ghosh A, Aziz W, Troakes C, Daoud J, et al . Alzheimer-related decrease in CYFIP2 links amyloid production to tau hyperphosphorylation and memory loss. Brain. 2016;139:2751-2765 pubmed | 
| western blot; human; loading ...; fig 2fwestern blot; mouse; loading ...; fig 2f
 | Hernandez Rapp J, Rainone S, Goupil C, Dorval V, Smith P, Saint Pierre M, et al . microRNA-132/212 deficiency enhances Aβ production and senile plaque deposition in Alzheimer's disease triple transgenic mice. Sci Rep. 2016;6:30953 pubmed  publisher | 
| western blot; human; loading ...; fig s7c
 | Lee S, Le Pichon C, Adolfsson O, Gafner V, Pihlgren M, Lin H, et al . Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement. Cell Rep. 2016;16:1690-1700 pubmed  publisher | 
| western blot; human; 1:5000; fig 5
 | Li T, Braunstein K, Zhang J, Lau A, Sibener L, Deeble C, et al . The neuritic plaque facilitates pathological conversion of tau in an Alzheimer's disease mouse model. Nat Commun. 2016;7:12082 pubmed  publisher | 
| immunohistochemistry - paraffin section; human; 1:3200; fig 5
 | Adams S, Tilton K, Kozubek J, Seshadri S, Delalle I. Subcellular Changes in Bridging Integrator 1 Protein Expression in the Cerebral Cortex During the Progression of Alzheimer Disease Pathology. J Neuropathol Exp Neurol. 2016;75:779-790 pubmed | 
| western blot; mouse; 1:10,000; fig 4immunohistochemistry - free floating section; human; 1:5000western blot; human; 1:10,000; fig 4
 | Wu J, Hussaini S, Bastille I, Rodriguez G, Mrejeru A, Rilett K, et al . Neuronal activity enhances tau propagation and tau pathology in vivo. Nat Neurosci. 2016;19:1085-92 pubmed  publisher | 
| western blot; rat; fig 1western blot; mouse; fig 1
 | Kim S, Choi K, Cho S, Yun S, Jeon J, Koh Y, et al . Fisetin stimulates autophagic degradation of phosphorylated tau via the activation of TFEB and Nrf2 transcription factors. Sci Rep. 2016;6:24933 pubmed  publisher | 
| western blot; human; 1:1000; fig 5
 | Yetman M, Fowler S, Jankowsky J. Humanized Tau Mice with Regionalized Amyloid Exhibit Behavioral Deficits but No Pathological Interaction. PLoS ONE. 2016;11:e0153724 pubmed  publisher | 
| western blot; mouse; fig 4
 | Yousuf M, Tan C, Torres Altoro M, Lu F, Plautz E, Zhang S, et al . Involvement of aberrant cyclin-dependent kinase 5/p25 activity in experimental traumatic brain injury. J Neurochem. 2016;138:317-27 pubmed  publisher | 
| western blot; mouse; fig 8
 | Winston C, Noël A, Neustadtl A, Parsadanian M, Barton D, Chellappa D, et al . Dendritic Spine Loss and Chronic White Matter Inflammation in a Mouse Model of Highly Repetitive Head Trauma. Am J Pathol. 2016;186:552-67 pubmed  publisher | 
| western blot; mouse; 1:10,000; fig 1
 | Sharma A, Lyashchenko A, Lu L, Nasrabady S, Elmaleh M, Mendelsohn M, et al . ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of function. Nat Commun. 2016;7:10465 pubmed  publisher | 
| immunohistochemistry; human; 1:500; fig 3
 | Bouge A, Parmentier M. Tau excess impairs mitosis and kinesin-5 function, leading to aneuploidy and cell death. Dis Model Mech. 2016;9:307-19 pubmed  publisher | 
| western blot; human; fig 2
 | Gentry E, Henderson B, Arrant A, Gearing M, Feng Y, Riddle N, et al . Rho Kinase Inhibition as a Therapeutic for Progressive Supranuclear Palsy and Corticobasal Degeneration. J Neurosci. 2016;36:1316-23 pubmed  publisher | 
|  | Chesser A, Ganeshan V, Yang J, Johnson G. Epigallocatechin-3-gallate enhances clearance of phosphorylated tau in primary neurons. Nutr Neurosci. 2016;19:21-31 pubmed  publisher | 
|  | Dimou E, Katsinelos T, Meisl G, Tuck B, Keeling S, Smith A, et al . Super-resolution imaging unveils the self-replication of tau aggregates upon seeding. Cell Rep. 2023;42:112725 pubmed  publisher | 
|  | Lopez D, Maltby C, Warming H, Divecha N, Vargas Caballero M, Coldwell M, et al . A luminescence-based reporter to study tau secretion reveals overlapping mechanisms for the release of healthy and pathological tau. Front Neurosci. 2023;17:1196007 pubmed  publisher | 
|  | Isei M, Girardi P, Rodwell Bullock J, Nehrke K, Johnson G. Site-specific phosphorylation of tau impacts mitochondrial biology and response to stressors. bioRxiv. 2023;: pubmed  publisher | 
|  | Kim Y, Siddiqui T, Blaze J, Cosacak M, Winters T, Kumar A, et al . RNA methyltransferase NSun2 deficiency promotes neurodegeneration through epitranscriptomic regulation of tau phosphorylation. Acta Neuropathol. 2023;145:29-48 pubmed  publisher | 
|  | Mart xed nez M xe1 rmol R, Small C, Jiang A, Palliyaguru T, Wallis T, Gormal R, et al . Fyn nanoclustering requires switching to an open conformation and is enhanced by FTLD-Tau biomolecular condensates. Mol Psychiatry. 2022;: pubmed  publisher | 
|  | Soutar M, Melandri D, O Callaghan B, Annuario E, Monaghan A, Welsh N, et al . Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson's disease at 16q11.2 and MAPT H1 loci. Brain. 2022;145:4349-4367 pubmed  publisher | 
|  | Conze C, Rierola M, Trushina N, Peters M, Janning D, Holzer M, et al . Caspase-cleaved tau is senescence-associated and induces a toxic gain of function by putting a brake on axonal transport. Mol Psychiatry. 2022;27:3010-3023 pubmed  publisher | 
|  | Palikaras K, Achanta K, Choi S, Akbari M, Bohr V. Alteration of mitochondrial homeostasis is an early event in a C. elegans model of human tauopathy. Aging (Albany NY). 2021;13:23876-23894 pubmed  publisher | 
|  | Miller L, Mukadam A, Durrant C, Vaysburd M, Katsinelos T, Tuck B, et al . Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue. Acta Neuropathol Commun. 2021;9:41 pubmed  publisher | 
|  | Ando K, Ferlini L, Suain V, Yilmaz Z, Mansour S, Le Ber I, et al . de novo MAPT mutation G335A causes severe brain atrophy, 3R and 4R PHF-tau pathology and early onset frontotemporal dementia. Acta Neuropathol Commun. 2020;8:94 pubmed  publisher | 
|  | Dobson Stone C, Hallupp M, Shahheydari H, Ragagnin A, Chatterton Z, Carew Jones F, et al . CYLD is a causative gene for frontotemporal dementia - amyotrophic lateral sclerosis. Brain. 2020;143:783-799 pubmed  publisher | 
|  | Marquié M, Agüero C, Amaral A, Villarejo Galende A, Ramanan P, Chong M, et al . [18F]-AV-1451 binding profile in chronic traumatic encephalopathy: a postmortem case series. Acta Neuropathol Commun. 2019;7:164 pubmed  publisher | 
|  | Chen J, Nathaniel D, Raghavan P, Nelson M, Tian R, Tse E, et al . Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation. J Biol Chem. 2019;294:18952-18966 pubmed  publisher | 
|  | Mancuso R, Fryatt G, Cleal M, Obst J, Pipi E, Monzón Sandoval J, et al . CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice. Brain. 2019;142:3243-3264 pubmed  publisher | 
|  | Pitera A, Asuni A, O Connor V, Deinhardt K. Pathogenic tau does not drive activation of the unfolded protein response. J Biol Chem. 2019;294:9679-9688 pubmed  publisher | 
|  | Ji C, Tang M, Zeidler C, Hohfeld J, Johnson G. BAG3 and SYNPO (synaptopodin) facilitate phospho-MAPT/Tau degradation via autophagy in neuronal processes. Autophagy. 2019;15:1199-1213 pubmed  publisher | 
|  | Paonessa F, Evans L, Solanki R, Larrieu D, Wray S, Hardy J, et al . Microtubules Deform the Nuclear Membrane and Disrupt Nucleocytoplasmic Transport in Tau-Mediated Frontotemporal Dementia. Cell Rep. 2019;26:582-593.e5 pubmed  publisher | 
|  | Harrison I, Whitaker R, Bertelli P, O Callaghan J, Csincsik L, Bocchetta M, et al . Optic nerve thinning and neurosensory retinal degeneration in the rTg4510 mouse model of frontotemporal dementia. Acta Neuropathol Commun. 2019;7:4 pubmed  publisher | 
|  | Julien C, Tomberlin C, Roberts C, Akram A, Stein G, Silverman M, et al . In vivo induction of membrane damage by β-amyloid peptide oligomers. Acta Neuropathol Commun. 2018;6:131 pubmed  publisher | 
|  | Cornelison G, Levy S, Jenson T, Frost B. Tau-induced nuclear envelope invagination causes a toxic accumulation of mRNA in Drosophila. Aging Cell. 2019;18:e12847 pubmed  publisher | 
|  | Srikanth P, Lagomarsino V, PEARSE R, Liao M, Ghosh S, Nehme R, et al . Convergence of independent DISC1 mutations on impaired neurite growth via decreased UNC5D expression. Transl Psychiatry. 2018;8:245 pubmed  publisher | 
|  | Beauchamp L, Chan J, Hung L, Padman B, Vella L, Liu X, et al . Ablation of tau causes an olfactory deficit in a murine model of Parkinson's disease. Acta Neuropathol Commun. 2018;6:57 pubmed  publisher | 
|  | Rousseaux M, Revelli J, Vázquez Vélez G, Kim J, Craigen E, Gonzales K, et al . Depleting Trim28 in adult mice is well tolerated and reduces levels of α-synuclein and tau. elife. 2018;7: pubmed  publisher | 
|  | Li C, Götz J. Pyk2 is a Novel Tau Tyrosine Kinase that is Regulated by the Tyrosine Kinase Fyn. J Alzheimers Dis. 2018;64:205-221 pubmed  publisher | 
|  | Stefanoska K, Volkerling A, Bertz J, Poljak A, Ke Y, Ittner L, et al . An N-terminal motif unique to primate tau enables differential protein-protein interactions. J Biol Chem. 2018;293:3710-3719 pubmed  publisher | 
|  | Biswas S, Kalil K. The Microtubule-Associated Protein Tau Mediates the Organization of Microtubules and Their Dynamic Exploration of Actin-Rich Lamellipodia and Filopodia of Cortical Growth Cones. J Neurosci. 2018;38:291-307 pubmed  publisher | 
|  | Dollé J, Jaye A, Anderson S, Ahmadzadeh H, Shenoy V, Smith D. Newfound sex differences in axonal structure underlie differential outcomes from in vitro traumatic axonal injury. Exp Neurol. 2018;300:121-134 pubmed  publisher | 
|  | Rodriguez Rodriguez P, Sandebring Matton A, Merino Serrais P, Parrado Fernandez C, Rabano A, Winblad B, et al . Tau hyperphosphorylation induces oligomeric insulin accumulation and insulin resistance in neurons. Brain. 2017;: pubmed  publisher | 
|  | Li C, Götz J. Somatodendritic accumulation of Tau in Alzheimer's disease is promoted by Fyn-mediated local protein translation. EMBO J. 2017;36:3120-3138 pubmed  publisher | 
|  | Nobuhara C, DeVos S, Commins C, Wegmann S, Moore B, Roe A, et al . Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro. Am J Pathol. 2017;187:1399-1412 pubmed  publisher | 
|  | Kurbatskaya K, Phillips E, Croft C, Dentoni G, Hughes M, Wade M, et al . Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer's disease brain. Acta Neuropathol Commun. 2016;4:34 pubmed  publisher | 
|  | Maj M, Hoermann G, Rasul S, Base W, Wagner L, Attems J. The Microtubule-Associated Protein Tau and Its Relevance for Pancreatic Beta Cells. J Diabetes Res. 2016;2016:1964634 pubmed  publisher | 
|  | Myeku N, CLELLAND C, Emrani S, Kukushkin N, Yu W, Goldberg A, et al . Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling. Nat Med. 2016;22:46-53 pubmed  publisher |