protein

Human PD-L1 Protein, His tag

PME100480

10 μg, 100 μg

60 USD, 338 USD

Human PD-L1 Protein, His tag

protein

10 μg, 100 μg

60 USD, 338 USD

Recombinant human PD-L1 protein with C-terminal 6×His tag

This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.

The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 23 % trehalose is added as protectants before lyophilization.

Research use only

Immunogen,WB,Elisa

Store at -80°C for 12 months (Avoid repeated freezing and thawing)