product summary
Loading...
company name :
DIMA Biotechnology
product type :
antibody
product name :
Anti-CS1 antibody(DM9)， Rabbit mAb
catalog :
DME100009
quantity :
10 μl, 100 μl
price :
60 USD, 398 USD
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
DM9
reactivity :
human
application :
flow cytometry
more info or order :
DIMA Biotechnology product webpage
image
image 1 :
DIMA Biotechnology DME100009 image 1
Figure 1. Flow cytometry data of serially titrated Rabbit anti-CS1 monoclonal antibody (clone: DM9) on Raji cells. The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used.
image 2 :
DIMA Biotechnology DME100009 image 2
Figure 2. Affinity ranking of different Rabbit anti-CS1 mAb clones by titration of different concentration onto Raji cells. The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used.
image 3 :
DIMA Biotechnology DME100009 image 3
Figure 3. Phylogenetic analysis of amino acid sequence of different Rabbit Anti-CS1 mAb clones. A) Heavy chain and B) Light chain.
product information
Catalog Number :
DME100009
Product Name :
Anti-CS1 antibody(DM9)， Rabbit mAb
Product Type :
antibody
Host Species :
Rabbit
Clonality :
Monoclonal
Conjugation :
Unconjugated
Antigen Modification :
no modification
Clone Name :
DM9
Isotype :
Rabbit IgG
Light Chain :
kappa
Size :
10 μl, 100 μl
List Price :
60 USD, 398 USD
SpeciesSummary :
Human
Background :
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed:23695528).
Immunogen :
Recombinant human CS1 (Ser23-Met226) produced by using human HEK293 cells
Specificity :
ELISA, Flow Cyt, IP, IF
Purity :
Purified from cell culture supernatant by affinity chromatography
Buffer :
50% Glycerol; PBS, pH 7.4; 0.1% BSA
Preservative :
0.1% Procline 300
Packaging :
10ul/100ul
Uses :
Research use only
Application Summary :
Flow Cyt  1/100
Storage :
Store at -20°C for 12 months (Avoid repeated freezing and thawing)
more info or order :
DIMA Biotechnology product webpage
company information
DIMA Biotechnology
Wuhan institute of Biotechnology B7
Biolake No.666 Gaoxin Road
Wuhan, Hubei
info@dimabio.com
https://www.dimabio.com
0118615307149771
headquarters: China
DIMA BIOTECH LTD (DIMABIO) focuses exclusively on the pre-clinical research market of Immune Oncology. Currently, we offer functional proteins and recombinant monoclonal antibodies. Our proprietary DimAb™ technology platform can directly clone IgG gene from immunized animal, which is a technology breakthrough in monoclonal antibody development.

All DIMABIOs protein products were manufactured by using mammalian cell expression system. To analyze the function of DIMABIOs proteins, we evaluated them by paired binding test between native ligand-receptor and or the binding capacity to the therapeutic antibodies. For DimAb™ recombinant monoclonal antibodies, we focus mainly on identifying clones with flow and blocking activity.