product summary
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company name :
DIMA Biotechnology
product type :
antibody
product name :
Anti-BCMA bispecific antibody(DM20)
catalog :
DMB100009
quantity :
10 μl, 100 μl
price :
60 USD, 398 USD
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
DM20
reactivity :
human
application :
flow cytometry
more info or order :
DIMA Biotechnology product webpage
image
image 1 :
DIMA Biotechnology DMB100009 image 1
Figure 1. The basic principle of BiTE cell killing assay. The BiTE molecule can effectively bring T cells to tumor target cells and stimulate tumor cell killing activity of T cells.
image 2 :
DIMA Biotechnology DMB100009 image 2
Figure 2. A: The scheme of Anti-BCMA BiTE molecule. B: Tumor cell killing assay. NCI-H929 cells (stably transfected with luciferase), were incubated with freshly isolated human PBMC, and different concentration of BiTE antibodies constructed from rabbit Anti-Human BCMA/TNFRSF17 Clone DM20 (red line), or BB2121 originated huC11D5.3 clone (blue line) or a no BCMA binding clone as negative control (black line). After 48hrs incubation, the viable NCI-H929 tumor cells were measured by luciferase activity assay.
image 3 :
DIMA Biotechnology DMB100009 image 3
Figure 2. A: The scheme of Anti-BCMA BiTE molecule. B: Tumor cell killing assay. NCI-H929 cells (stably transfected with luciferase), were incubated with freshly isolated human PBMC, and different concentration of BiTE antibodies constructed from rabbit Anti-Human BCMA/TNFRSF17 Clone DM20 (red line), or BB2121 originated huC11D5.3 clone (blue line) or a no BCMA binding clone as negative control (black line). After 48hrs incubation, the viable NCI-H929 tumor cells were measured by luciferase activity assay.
product information
Catalog Number :
DMB100009
Product Name :
Anti-BCMA bispecific antibody(DM20)
Product Type :
antibody
Host Species :
Rabbit
Clonality :
Monoclonal
Conjugation :
Unconjugated
Antigen Modification :
no modification
Clone Name :
DM20
Isotype :
Rabbit IgG
Light Chain :
kappa
Size :
10 μl, 100 μl
List Price :
60 USD, 398 USD
SpeciesSummary :
Human
Background :
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]
Immunogen :
Recombinant human BCMA (Met1-Ala54) produced by using human HEK293 cells
Specificity :
Flow Cyt, MM Tumor cell killing
Purity :
Purified from cell culture supernatant by affinity chromatography
Buffer :
50% Glycerol; PBS, pH 7.4; 0.1% BSA
Preservative :
0.1% Procline 300
Packaging :
10ul/100ul
Uses :
Research use only
Application Summary :
Flow Cyt  1/100; MMTumor cell killing
Storage :
Store at -20°C for 12 months (Avoid repeated freezing and thawing)
more info or order :
DIMA Biotechnology product webpage
company information
DIMA Biotechnology
Wuhan institute of Biotechnology B7
Biolake No.666 Gaoxin Road
Wuhan, Hubei
info@dimabio.com
https://www.dimabio.com
0118615307149771
headquarters: China
DIMA BIOTECH LTD (DIMABIO) focuses exclusively on the pre-clinical research market of Immune Oncology. Currently, we offer functional proteins and recombinant monoclonal antibodies. Our proprietary DimAb™ technology platform can directly clone IgG gene from immunized animal, which is a technology breakthrough in monoclonal antibody development.

All DIMABIOs protein products were manufactured by using mammalian cell expression system. To analyze the function of DIMABIOs proteins, we evaluated them by paired binding test between native ligand-receptor and or the binding capacity to the therapeutic antibodies. For DimAb™ recombinant monoclonal antibodies, we focus mainly on identifying clones with flow and blocking activity.