product summary
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company name :
Creative Diagnostics
product type :
antibody
product name :
Mouse Anti-Sheep SPAM1 monoclonal antibody, clone 2B5
catalog :
DMABA-JX118
quantity :
100 μg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
2B5
reactivity :
human
application :
western blot, immunocytochemistry
more info or order :
Creative Diagnostics product webpage
product information
Catalog :
DMABA-JX118
proudctName :
Mouse Anti-Sheep SPAM1 monoclonal antibody, clone 2B5
common :
SPAM1
Short Name :
CASS5 Antibody
Source/Host :
Mouse
Html Name :
Anti-Sheep SPAM1 monoclonal antibody
Html subtitle :
Mouse Anti-Sheep SPAM1 monoclonal antibody for ICC, WB
Common name :
SPAM1
Species :
Sheep
Conjugate :
Unconjugated
Application :
ICC, WB
Application Notes :
ICC, WB Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Immunogen :
Sheep SPAM1 full length native protein
Antibody Isotype :
IgG1
Size :
100 μg
Storage :
Store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Species Reactivity :
Sheep
Clone :
2B5
Purification :
Affinity purification
Format :
Purified, Liquid
Concentration :
Lot specific
Buffer :
PBS containing 0.01% sodium azide
Preservative :
0.01% sodium azide
Ship :
Wet ice
Warning :
This product is for research use only and is not intended for diagnostic use.
Introduction :
Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene.
Keywords :
SPAM1; sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding); HYA1; PH20; HYAL1; HYAL3; HYAL5; PH-20; SPAG15; HEL-S-96n; hyaluronidase PH-20; hyalPH20; sperm surface protein PH-20; hyaluronoglucosaminidase PH-20; epididymis secretory sperm binding protein Li 96n;
UniProt ID :
P38567
Clonality :
Monoclonal
more info or order :
Creative Diagnostics product webpage
company information
Creative Diagnostics
NY, USA
contact@creative-diagnostics.com
http://www.creative-diagnostics.com
1-631-624-4882
headquarters: USA
Creative Diagnostics is a leading manufacturer and supplier of antibodies, viral antigens, innovative diagnostic components, and critical assay reagents. We provide contract biologic R&D and manufacturing services to the diagnostic manufacturers along with GMP biologics manufacturing for the biopharmaceutical market. Our goal is to be a trusted source for all your assay development and manufacturing needs.
We also assist clients with rapidly developing, manufacturing, and commercializing point of care lateral flow, flow through, and ELISA assays. Our specialties are producing fluorescent, visual colloidal gold, and paramagnetic labels, and highly sensitive, quantitative, and reader-based tests.
With decades of experiences and our unique technologies, Creative Diagnostics is committed to providing its customers the highest quality products and services.