product summary
Loading...
company name :
Creative Diagnostics
product type :
antibody
product name :
Mouse Anti-Human CD64 (FCGR1) Monoclonal Antibody, clone 10.1 [Functional Grade]
catalog :
DCABH-6301
quantity :
1 mg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
10.1
reactivity :
human
application :
immunohistochemistry, flow cytometry
more info or order :
Creative Diagnostics product webpage
product information
Catalog :
DCABH-6301
proudctName :
Mouse Anti-Human CD64 (FCGR1) Monoclonal Antibody, clone 10.1 [Functional Grade]
common :
FCGR1A
Short Name :
FCGR1A antibody
Source/Host :
Mouse
Html Name :
Anti-Human CD64 (FCGR1) monoclonal antibody, Functional Grade
Html subtitle :
Mouse anti-Human CD64 (FCGR1) monoclonal antibody for BL, FA, FC, IHC
Common name :
FCGR1A
Species :
Human
Conjugate :
Functional Grade
Application :
BL, FA, FC, IHC
Application Notes :
Recommended concentration: FC: ≤ 1 μg per 10^6 cells in a volume of 100 μl or 100μl of whole blood.
Immunogen :
Rheumatoid synovial fluid cells and fibronectin purified human monocytes.
Antibody Isotype :
IgG1, κ
Size :
1 mg
Storage :
Functional grade biosimilar antibodies may be stored sterile as received at 2-8℃ for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80℃. Avoid Repeated Freeze Thaw Cycles.
Species Reactivity :
Human
Clone :
10.1
Purification :
Protein A or G purified
Alternative Names :
FCGR1A; Fc fragment of IgG, high affinity Ia, receptor (CD64); Fc fragment of IgG, high affinity Ia, receptor for (CD64); high affinity immunoglobulin gamma Fc receptor I; CD64; CD64A
Format :
Liquid
Concentration :
Lot specific
Buffer :
0.01 M phosphate buffered saline (PBS) pH 7.2 - 7.4, 150 mM NaCl with no carrier protein, potassium, calcium or preservatives added. Endotoxin Level ≤ 1.0 EU/mg as determined by the LAL method
Ship :
Wet ice
Warning :
This product is for research use only and is not intended for diagnostic use.
Introduction :
FCGR1 is expressed on monocytes, macrophages, dendritic cells (DCs), and activated granulocytes. FCGR1 is a 72 kDa type I transmembrane glycoprotein expressed on monocytes, macrophages, and dendritic cells (DCs). FCGR1 can also be induced on neutrophils with IFNγ and G-CSF1. FCGR1 binds with high affinity to monomeric IgG1 and IgG3, and to a lesser extent, IgG4, resulting in phosphorylation of the intracellular FCGR1 ITAM motif and subsequent recruitment of Syk. FCGR1 contributes to inflammation via several mechanisms, including promoting antibody-dependent cell-mediated cytotoxicity (ADCC), clearance of immune complexes, cytokine production, and antigen presentation1. CD64-based targeted therapies eliminate M1 pro-inflammatory macrophages and show clinical potential for the treatment of macrophage-mediated chronic inflammatory diseases, such as chronic cutaneous inflammation and rheumatoid arthritis. In addition, CD64 promotes antitumor responses and mediates cytotoxic killing of tumor cells by macrophages.
Keywords :
FCGR1A;Fc fragment of IgG, high affinity Ia, receptor (CD64);Fc fragment of IgG, high affinity Ia, receptor for (CD64);high affinity immunoglobulin gamma Fc receptor I;CD64;CD64A
Gene Name :
FCGR1A
UniProt ID :
P12314
Product Overview :
Low endotoxin level (≤ 1.0 EU/mg) monoclonal antibody recognizes the alpha subunit of human FCGR1. More Lower endotoxin level (≤ 0.5 EU/mg) antibody is also available.
applicatons :
BL, FA, FC, IHC Recommended concentration: FC: ≤ 1 μg per 10^6 cells in a volume of 100 μl or 100μl of whole blood.
Clonality :
Monoclonal
more info or order :
Creative Diagnostics product webpage
company information
Creative Diagnostics
NY, USA
contact@creative-diagnostics.com
http://www.creative-diagnostics.com
1-631-624-4882
headquarters: USA
Creative Diagnostics is a leading manufacturer and supplier of antibodies, viral antigens, innovative diagnostic components, and critical assay reagents. We provide contract biologic R&D and manufacturing services to the diagnostic manufacturers along with GMP biologics manufacturing for the biopharmaceutical market. Our goal is to be a trusted source for all your assay development and manufacturing needs.
We also assist clients with rapidly developing, manufacturing, and commercializing point of care lateral flow, flow through, and ELISA assays. Our specialties are producing fluorescent, visual colloidal gold, and paramagnetic labels, and highly sensitive, quantitative, and reader-based tests.
With decades of experiences and our unique technologies, Creative Diagnostics is committed to providing its customers the highest quality products and services.