product summary
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company name :
Creative Diagnostics
product type :
antibody
product name :
Mouse Anti-Dxd monoclonal antibody, clone 13
catalog :
CABT-L828M
quantity :
100 μL
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
13
application :
ELISA
more info or order :
Creative Diagnostics product webpage
product information
Catalog :
CABT-L828M
proudctName :
Mouse Anti-Dxd monoclonal antibody, clone 13
common :
Dxd
Short Name :
Dxd antibody
Source/Host :
Mouse
Common name :
Dxd
Conjugate :
Unconjugated
Application :
ELISA
Antibody Isotype :
IgG
Size :
100 μL
Storage :
Short term: store at -20°C. Long term: aliquot and store at -80°C.
Target :
Dxd
Clone :
13
Purification :
Affinity Chromatography
Alternative Names :
Dxd
Format :
Purified, Liquid
Concentration :
Lot specific
Buffer :
0.01M PBS
Ship :
Wet ice
Warning :
This product is for research use only and is not intended for diagnostic use.
Introduction :
Dxd (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor, with an IC50 of0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a). Dxd is cytotoxic tohuman cancer cell lines of KPL-4, NCI-N87, SK-BR-3, and MDA-MB-468 with IC50s of 1.43nM-4.07 nM, but the control IgG-ADC (Dxd is the payload) shows no inhibition on the four celllines (with HER2 expression). DS-8201a (Dxd is the payload) displays significant suppression onthe HER2-positive KPL-4, NCI-N87, and SK-BR-3 cell lines, with IC50 values of 26.8, 25.4, and6.7 ng/mL, respectively, but with no such inhibition on MDA-MB-468 (IC50,>10,000 ng/mL).
Keywords :
Dxd
Synonyms :
Dxd
applicatons :
ELISA
Clonality :
Monoclonal
more info or order :
Creative Diagnostics product webpage
company information
Creative Diagnostics
NY, USA
contact@creative-diagnostics.com
http://www.creative-diagnostics.com
1-631-624-4882
headquarters: USA
Creative Diagnostics is a leading manufacturer and supplier of antibodies, viral antigens, innovative diagnostic components, and critical assay reagents. We provide contract biologic R&D and manufacturing services to the diagnostic manufacturers along with GMP biologics manufacturing for the biopharmaceutical market. Our goal is to be a trusted source for all your assay development and manufacturing needs.
We also assist clients with rapidly developing, manufacturing, and commercializing point of care lateral flow, flow through, and ELISA assays. Our specialties are producing fluorescent, visual colloidal gold, and paramagnetic labels, and highly sensitive, quantitative, and reader-based tests.
With decades of experiences and our unique technologies, Creative Diagnostics is committed to providing its customers the highest quality products and services.