product summary
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company name :
Creative Diagnostics
product type :
antibody
product name :
Anti-MMAE monoclonal antibody, clone 3F3
catalog :
CABT-B8992
quantity :
100 μl
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
3F3
application :
ELISA
more info or order :
Creative Diagnostics product webpage
product information
Catalog :
CABT-B8992
proudctName :
Anti-MMAE monoclonal antibody, clone 3F3
common :
MMAE
Short Name :
MMAE antibody
Source/Host :
Mouse
Html Name :
Anti-MMAE monoclonal antibody
Html subtitle :
Mouse Anti-MMAE monoclonal antibody for ELISA
Common name :
MMAE
Conjugate :
Unconjugated
Application :
ELISA
Immunogen :
MMAE [KLH]
Antibody Isotype :
IgG1
Size :
100 μl
Storage :
4°C for 2 weeks, -80°C for 2 years.
Antigen Description :
MMAE [BSA]
Target :
Monomethyl auristatin E
Clone :
3F3
Affinity Constant :
Kd > 2.76×10^-9
Purification :
Affinity Chromatography
Alternative Names :
Monomethyl auristatin E
Format :
Liquid
Buffer :
0.01M PBS
Introduction :
Monomethyl auristatin E (MMAE) is a synthetic antineoplastic agent. Because of its toxicity, it cannot be used as a drug itself; instead, it is linked to a monoclonal antibody (MAB) which directs it to the cancer cells. In International Nonproprietary Names for MMAE-MAB-conjugates, the name vedotin refers to MMAE plus its linking structure to the antibody. It is a potent antimitotic drug derived from peptides occurring in marine shell-less mollusc Dolabella auricularia called dolastatins which show potent activity in preclinical studies, both in vitro and in vivo, against a range of lymphomas, leukemia and solid tumors. These drugs show potency of up to 200 times that of vinblastine, another antimitotic drug used for Hodgkin lymphoma as well as other types of cancer. MMAE is actually desmethyl-auristatin E; that is, the N-terminal amino group has only one methyl substituent instead of two as in auristatin E itself.
Keywords :
Monomethyl auristatin E
applicatons :
ELISA
Clonality :
Monoclonal
more info or order :
Creative Diagnostics product webpage
company information
Creative Diagnostics
NY, USA
contact@creative-diagnostics.com
http://www.creative-diagnostics.com
1-631-624-4882
headquarters: USA
Creative Diagnostics is a leading manufacturer and supplier of antibodies, viral antigens, innovative diagnostic components, and critical assay reagents. We provide contract biologic R&D and manufacturing services to the diagnostic manufacturers along with GMP biologics manufacturing for the biopharmaceutical market. Our goal is to be a trusted source for all your assay development and manufacturing needs.
We also assist clients with rapidly developing, manufacturing, and commercializing point of care lateral flow, flow through, and ELISA assays. Our specialties are producing fluorescent, visual colloidal gold, and paramagnetic labels, and highly sensitive, quantitative, and reader-based tests.
With decades of experiences and our unique technologies, Creative Diagnostics is committed to providing its customers the highest quality products and services.