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company name :
Creative Diagnostics
product type :
antibody
product name :
Anti-PTHRP (aa 1-34) monoclonal antibody, clone 34-68-248-2
catalog :
CABT-B1128
quantity :
200 μg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
34-68-248-2
reactivity :
human
application :
western blot, neutralization
more info or order :
Creative Diagnostics product webpage
product information
Catalog :
CABT-B1128
proudctName :
Anti-PTHRP (aa 1-34) monoclonal antibody, clone 34-68-248-2
common :
PTHLH
Short Name :
PTHRP antibody
Source/Host :
Mouse
Html Name :
Anti-PTHRP monoclonal antibody
Html subtitle :
Mouse Anti-Human PTHRP monoclonal antibody for WB, Neut
Common name :
PTHLH
Species :
Human
Conjugate :
Unconjugated
Application :
WB, Neut
Application Notes :
WB: 0.5 μg/mL of this antibody detected PTHrP(1-34) in 1 μg of human PTHrP recombinant protein. The antibody blocks the binding of PTHrP to parathyroid hormone receptor 1 through binding to a site closely overlapping with the receptor-interacting site at the extracellular loop and juxtamembrane regions. The antibody does not block the action of parathyroid hormone (PTH) through the same receptor. The antibody inhibits the action of PTHrP-(1–34) in promoting cAMP production by osteosarcoma cells by 90%,. The antibody also functions in vivo, and can treat nude mice rendered hypercalcemic by PAN-7-JCK cells, and prevents cachexia in mice bearing the LC6-JCK human lung cancer xenograft, independent of the calcium-lowering effect of the antibody.
Immunogen :
Bovine thyroglobulin-conjugated linear peptide corresponding to human PTHrP(1-34).
Antibody Isotype :
IgG1,
Size :
200 μg
Storage :
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Specificity :
This monoclonal detects PTHrP(1-34)/PTHrP(1-36), but not PTHrP(38-94) or Osteostatin.
Species Reactivity :
Human
Clone :
34-68-248-2
Purification :
Protein G Purified
Epitope :
PTHrP(1-34)
Molecular Weight :
~10 kDa observed
Alternative Names :
PTHLH; parathyroid hormone-like hormone; parathyroid hormone-related protein; osteostatin; PLP
Format :
Liquid
Concentration :
Please refer to lot specific datasheet.
Buffer :
PBS without preservatives.
Introduction :
Mouse F4/80 antigen, a 125 kDa transmembrane protein widely expressed by members of the mononuclear phagocyte system and considered to be a key marker for mature macrophage cells. F4/80 is differentially expressed during myeloid cell development, and may be regulated by certain cytokines within the tissue microenvironment. Other cell types shown to express this antigen include Langerhans cells, Kupffer cells and dendritic cell subsets.
UniProt ID :
P12272
applicatons :
WB, Neut
Clonality :
Monoclonal
more info or order :
Creative Diagnostics product webpage
company information
Creative Diagnostics
NY, USA
contact@creative-diagnostics.com
http://www.creative-diagnostics.com
1-631-624-4882
headquarters: USA
Creative Diagnostics is a leading manufacturer and supplier of antibodies, viral antigens, innovative diagnostic components, and critical assay reagents. We provide contract biologic R&D and manufacturing services to the diagnostic manufacturers along with GMP biologics manufacturing for the biopharmaceutical market. Our goal is to be a trusted source for all your assay development and manufacturing needs.
We also assist clients with rapidly developing, manufacturing, and commercializing point of care lateral flow, flow through, and ELISA assays. Our specialties are producing fluorescent, visual colloidal gold, and paramagnetic labels, and highly sensitive, quantitative, and reader-based tests.
With decades of experiences and our unique technologies, Creative Diagnostics is committed to providing its customers the highest quality products and services.