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product summary
company name :
Creative BioMart
product type :
protein
product name :
Recombinant Human Cytomegalovirus UL55, His-tagged
catalog :
UL55-3328H
product information
Cat :
UL55-3328H
Product Name :
Recombinant Human Cytomegalovirus UL55, His-tagged
Brand :
Creative Biomart
gene symbal :
UL55
gene name :
envelope glycoprotein B
Synonyms :
UL55; type 1 membrane protein; possible membrane fusogen; binds cell surface heparan sulphate; involved in cell entry; involved in cell-to-cell spread; envelope glycoprotein B
Product Overview :
Recombinant Human CMV gB (extracellular domain, (Met 1- Lys 700), linked with the cytoplasmic domain (Arg 777- Val 907 )), fused with a His-tag at C-terminus, was expressed inHuman Cells.
Description :
Recombinant Human CMV gB (extracellular domain, (Met 1- Lys 700), linked with the cytoplasmic domain (Arg 777- Val 907 )), fused with a His-tag at C-terminus, was expressed inHuman Cells.Human cytomegalovirus(CMV) (human herpesvirus 5) glycoprotein B is a 907-amino acid glycoprotein encoded by the ORF of UL55. It is the most abundant component of the envelope with at least two defined neutralizing epitopes, a target of neutralizing antibodies and an essential replication component. The synthesized gB precursor matures into a 130-160 kDa glycoprotein by acquiring N-linked glycosylation modifications, and is cleaved by the cellular protease furin into two components, a 93-116 kDa N-terminal fragment and a 55 kDa C-terminal fragment linked by a disulfide-bond, which is presented on the viral envelope as well as on the surface of virus-infected cells as a covalently associated homodimer. gB plays important roles in HCMV entry, cell-cell spread of internal virions, and fusion of infected cells. It triggers penetration of cells and enhances the spread of infection in nonpolarized human fibroblasts. The interaction of gB with the non-heparin receptor CD209/DC-SIGN is the initiation of intracellular signaling and activation of the IFN-responsive pathway. In addition, gB is one envelope protein capable of heparin binding. It forms a physical association with host cell annexin II independent of the presence of calcium.
Source :
Human Cells
Purity :
95% as determined by SDS-PAGE.
Storage :
Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
company information
Creative BioMart
Creative BioMart provides quality recombinant proteins, diagnostic antibodies and antigens, diagnostic enzymes and pharmaceutical enzymes to the research community of biology, clinical research, molecular diagnostics and biopharmaceutical drug development.
We are offering more than 3,000 recombinant proteins, peptides and antibodies. All the products are rigorously tested to meet the most demanding research needs. At the same time, lowest prices in the industry are always guaranteed.
Also, in order to leverage our core competencies and resources, Creative BioMart has formed a large number of corporate partnerships and academic collaborations for product development and distribution. We welcome potential partners and distributors to explore business relationships with Creative BioMart.
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