This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Creative BioMart
product type :
protein
product name :
Recombinant Ovine Trophoblast Protein-1
catalog :
TP-1-38O
product information
Cat :
TP-1-38O
Product Name :
Recombinant Ovine Trophoblast Protein-1
Brand :
Creative Biomart
gene symbal :
TNP1
gene name :
transition protein 1 (during histone to protamine replacement)
Synonyms :
Interferon-tau; TP-1; trophoblast protein-1; Trophoblastin; Antiluteolysin; Trophoblast antiluteolytic protein; OTP; IFNT1; IFNT4; Interferon tau-1; Interferon tau-4
Product Overview :
Recombinant Ovine Interferon-Tau produced in E.coli is a single, non-glycosylated, polypeptide chain containing 172 amino acids and having a molecular mass of 19914.7 Dalton. The IFN-Tau is purified by proprietary chromatographic techniques.
Description :
Recombinant Ovine Interferon-Tau produced in E.coli is a single, non-glycosylated, polypeptide chain containing 172 amino acids and having a molecular mass of 19914.7 Dalton. The IFN-Tau is purified by proprietary chromatographic techniques.IFN-tau is also known as TP-1 (trophoblast protein-1) is a new class of type I IFN that is secreted by the trophoblast and is the signal for maternal recognition of pregnancy in sheep. IFN- tau has potent immunosuppressive and antiviral activities similar to other type I IFN but is less cytotoxic than IFN-alpha and IFN-beta. The current investigation concerns the effect of recombinant ovine IFN- tau (rOIFN- tau) on the modulation of MHC class I and II expression on cloned mouse cerebrovascular endothelial (CVE) cells. IFN-tau induced tyrosine phosphorylation of Stat1 and upregulated the expression of MHC class I on CVE. One proposed action by which type I IFN reduces the relapse rate in MS is via interference with IFN-γ-induced MHC class II expression. IFN- tau was shown to downregulate IFN-γ-induced MHC class II expression on CVE and, hence, may be of potential therapeutic value in downregulating inflammation in the central nervous system (CNS). IFN- tau did not upregulate the expression of MHC class II on CVE. IFN- tau also inhibited the replication of Theiler"s virus in CVE.
Source :
Escherichia Coli
Purity :
Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
UniProt ID :
P56828
company information
Creative BioMart
Creative BioMart provides quality recombinant proteins, diagnostic antibodies and antigens, diagnostic enzymes and pharmaceutical enzymes to the research community of biology, clinical research, molecular diagnostics and biopharmaceutical drug development.
We are offering more than 3,000 recombinant proteins, peptides and antibodies. All the products are rigorously tested to meet the most demanding research needs. At the same time, lowest prices in the industry are always guaranteed.
Also, in order to leverage our core competencies and resources, Creative BioMart has formed a large number of corporate partnerships and academic collaborations for product development and distribution. We welcome potential partners and distributors to explore business relationships with Creative BioMart.
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