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product summary
company name :
Creative BioMart
product type :
protein
product name :
Recombinant Human TNFSF18,His-tagged
catalog :
TNFSF18-145H
product information
Cat :
TNFSF18-145H
Product Name :
Recombinant Human TNFSF18,His-tagged
Brand :
Creative Biomart
gene symbal :
TNFSF18
gene name :
tumor necrosis factor (ligand) superfamily, member 18
Synonyms :
TNFSF18; tumor necrosis factor (ligand) superfamily, member 18; Activation inducible TNF related ligand; Activation-inducible TNF-related ligand; AITRL; GITRL; Glucocorticoid induced TNF related ligand; Glucocorticoid induced TNFR related protein ligand; Glucocorticoid-induced TNF-related ligand; hGITRL; MGC138237; TL6; TNF18_HUMAN; Tumor necrosis factor (ligand) superfamily member 18; Tumor necrosis factor ligand superfamily member 18; GITR ligand; OTTMUSP00000033308; glucocorticoid-induced-tumor necrosis factor receptor ligand
Product Overview :
Recombinant Human AITRL His-Tagged Protein, produced inE. coli, is 15.7 kDa (calculated) protein containing 125 amino acid residues of the human AITRL and 14 additional amino acid residues - HisTag (underlined). The amino acid sequence of the recombinant human Osteostat is homologous to the extracellular domain of the human TNF18, Thr53-Ser177.
Description :
Recombinant Human AITRL His-Tagged Protein, produced inE. coli, is 15.7 kDa (calculated) protein containing 125 amino acid residues of the human AITRL and 14 additional amino acid residues - HisTag (underlined). The amino acid sequence of the recombinant human Osteostat is homologous to the extracellular domain of the human TNF18, Thr53-Ser177.Osteostat is the cytokine that binds to TNFRSF18/AITR/GITR and is important for interactions between activated T-lymphocytes and endothelial cells and may modulate T-lymphocyte survival in peripheral tissues. Osteostat is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells after stimulation by lipopolysaccharides. Osteostat protein is detectable in human microvascular EC and is highly up-regulated by IFN-alpha and IFN-beta. Osteostat inhibit differentiation of osteoclasts from monocytic precursor cells. Osteostat suppresses the early stage of osteoclastogenesis via inhibition of macrophage colony-stimulating factorinduced receptor activator of NF-kappaB (RANK) expression in the osteoclast precursor cells. Osteostat does not inhibit lipopolysaccharide-induced RANK expression in monocytes and dendritic cells, or activation-induced RANK expression in T cells. Osteostat is a novel regulator of osteoclast generation and substantiate the major role played by the endothelium in bone physiology.
Source :
Escherichia Coli
Purity :
Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
UniProt ID :
Q9UNG2
company information
Creative BioMart
Creative BioMart provides quality recombinant proteins, diagnostic antibodies and antigens, diagnostic enzymes and pharmaceutical enzymes to the research community of biology, clinical research, molecular diagnostics and biopharmaceutical drug development.
We are offering more than 3,000 recombinant proteins, peptides and antibodies. All the products are rigorously tested to meet the most demanding research needs. At the same time, lowest prices in the industry are always guaranteed.
Also, in order to leverage our core competencies and resources, Creative BioMart has formed a large number of corporate partnerships and academic collaborations for product development and distribution. We welcome potential partners and distributors to explore business relationships with Creative BioMart.
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