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product summary
company name :
Creative BioMart
product type :
protein
product name :
Recombinant Human Signal Transducer And Activator Of Transcription 3
catalog :
STAT3-73H
product information
Cat :
STAT3-73H
Product Name :
Recombinant Human Signal Transducer And Activator Of Transcription 3
Brand :
Creative Biomart
gene symbal :
STAT3
gene name :
Signal Transducer And Activator Of Transcription 3 (Acute-Phase Response Factor)
Synonyms :
STAT3; signal transducer and activator of transcription 3 (acute-phase response factor); APRF; HIES; FLJ20882; MGC16063; OTTHUMP00000198123; OTTHUMP00000198128; DNA-binding protein APRF; acute-phase response factor
Product Overview :
Recombinant Human STAT3 encoding 50-240aa expressed in E.coli The Stat3 protein is transcription factor expressed in most cell types and is activated by multiple cytokines and growth factors including: IFN-a, IL-10, IL-6, IL-11, IL-12, IL-2, EGF etc.
Description :
Recombinant Human STAT3 encoding 50-240aa expressed in E.coli The Stat3 protein is transcription factor expressed in most cell types and is activated by multiple cytokines and growth factors including: IFN-a, IL-10, IL-6, IL-11, IL-12, IL-2, EGF etc.STAT3 is tyrosine-phosphorylated and activated by a number of kinases. The binding of IL-6 family cytokines (including IL-6, oncostatin M and leukemia inhibitory factor) to the gp130 receptor triggers STAT3 phosphorylation by JAK2. EGF-R and certain other receptor tyrosine kinases, such as c-MET phosphorylate STAT3 in response to their ligands. STAT3 is also a target of the c-src non-receptor tyrosine kinase. STAT3-deficient mouse embryos can not develop beyond embryonic day 7 (E7.0), when gastrulation initiates. It appears that at these early stages of development, STAT3 activation is required for self-renewal of embryonic stem cells (ESCs). Indeed, LIF, which is supplied to ESC cultures to maintain their undifferentiated state, can be omitted if STAT3 is activated through some other means. Constitutive STAT3 activation is associated with various human cancers and commonly suggests poor prognosis. It has anti-apoptotic as well as proliferative effects.
Source :
Escherichia Coli
Purity :
Greater than 95% as determined by SDS-PAGE.
Storage :
1 week at 14 C. For longer periods of time store vial at -20 C to -80 C.When stored at the recommended temperature, this protein is stable for 12 months. Avoid multiple freeze-thaw cycles.
UniProt ID :
P40763
company information
Creative BioMart
NY, USA
contact@creative-biomart.com
http://www.creativebiomart.net
1-516-855-7709
headquarters: USA
Creative BioMart provides quality recombinant proteins, diagnostic antibodies and antigens, diagnostic enzymes and pharmaceutical enzymes to the research community of biology, clinical research, molecular diagnostics and biopharmaceutical drug development.

We are offering more than 3,000 recombinant proteins, peptides and antibodies. All the products are rigorously tested to meet the most demanding research needs. At the same time, lowest prices in the industry are always guaranteed.

Also, in order to leverage our core competencies and resources, Creative BioMart has formed a large number of corporate partnerships and academic collaborations for product development and distribution. We welcome potential partners and distributors to explore business relationships with Creative BioMart.