This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Creative BioMart
product type :
protein
product name :
Recombinant Human SPARC
catalog :
SPARC-11H
product information
Cat :
SPARC-11H
Product Name :
Recombinant Human SPARC
Brand :
Creative Biomart
gene symbal :
SPARC
gene name :
secreted protein, acidic, cysteine-rich (osteonectin)
Synonyms :
ON; BM-40; Osteonectin; Basement-membrane protein 40; Osteonectin (secreted protein, acidic, cysteine-rich); SPARC precursor; Secreted protein acidic and rich in cysteine; cysteine-rich protein; secreted protein, acidic, cysteine-rich (osteonectin); SPRC_HUMAN; SPARC [Precursor]; SPARC
Product Overview :
Recombinant Human SPARC produced in E.coli is a single non-glycosylated polypeptide chain containing 295 amino acids and having a molecular mass of approximately 34.0 kDa.
Description :
Recombinant Human SPARC produced in E.coli is a single non-glycosylated polypeptide chain containing 295 amino acids and having a molecular mass of approximately 34.0 kDa.SPARC, an acronym for secreted protein, acidic and rich in cysteine , is also known as osteonectin or BM-40. It is the founding member of a family of secreted matricellular proteins with similar domain structure. The 303 amino acid , 43 kDa protein contains a 17 aa signal sequence, an N-terminal acidic region that binds calcium, a follistatin domain containing Kazal-like sequences, and a C-terminal extracellular calcium (EC) binding domain with two EF-hand motifs . SPARC is produced by fibroblasts, capillary endothelial cells, platelets and macrophages,especially in areas of tissue morphogenesis and remodeling. SPARC shows context-specific effects, but generally inhibits adhesion, spreading and proliferation, and promotes collagen matrix formation. For endothelial cells,SPARC disrupts focal adhesions and binds and sequesters PDGF and VEGF. SPARC is abundantly expressed in bone, where it promotes osteoblast differentiation and inhibits adipogenesis.
Purity :
95% by SDS-PAGE and HPLC analyses.
Storage :
This lyophilized preparation is stable for several weeks at 2-8 C, but should be kept at -20 C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 C to -70 C. Avoid repeated freeze/thaw cycles.
UniProt ID :
P09486
company information
Creative BioMart
Creative BioMart provides quality recombinant proteins, diagnostic antibodies and antigens, diagnostic enzymes and pharmaceutical enzymes to the research community of biology, clinical research, molecular diagnostics and biopharmaceutical drug development.
We are offering more than 3,000 recombinant proteins, peptides and antibodies. All the products are rigorously tested to meet the most demanding research needs. At the same time, lowest prices in the industry are always guaranteed.
Also, in order to leverage our core competencies and resources, Creative BioMart has formed a large number of corporate partnerships and academic collaborations for product development and distribution. We welcome potential partners and distributors to explore business relationships with Creative BioMart.
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