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product summary
company name :
Creative BioMart
product type :
protein
product name :
Recombinant Human SGK1, GST-tagged
catalog :
SGK1-644H
product information
Cat :
SGK1-644H
Product Name :
Recombinant Human SGK1, GST-tagged
Brand :
Creative Biomart
gene symbal :
SGK1
gene name :
serum/glucocorticoid regulated kinase 1
Synonyms :
SGK1; serum/glucocorticoid regulated kinase 1; serum/glucocorticoid regulated kinase , SGK; serine/threonine-protein kinase Sgk1; serine/threonine protein kinase SGK; serum/glucocorticoid-regulated kinase 1; SGK
Product Overview :
Recombinant Human Serum/Glucocorticoid Regulated Kinase 1 was expressed inE. coli.It was fused with a GST tag at the N-terminus. This protein is truncated by 60 amino acids at the N-terminus to improve stability. This protein has an apparent molecular weight of 73 kDa.
Description :
Recombinant Human Serum/Glucocorticoid Regulated Kinase 1 was expressed inE. coli.It was fused with a GST tag at the N-terminus. This protein is truncated by 60 amino acids at the N-terminus to improve stability. This protein has an apparent molecular weight of 73 kDa.SGK1 is a member of the serum- and glucocorticoid-induced protein kinase family. SGK1 is activated in vitro by 3-phosphoinositidedependent protein kinase-1 (PDK1) and in vivo in response to signals that activate phosphatidylinositol (PI) 3-kinase (1). SGK1, mRNA is expressed in all tissues and the level of SGK1 mRNA is increased by stimulation with serum or dexamethasone. SGK1 promotes cell survival by phosphorylating and inactivating FKHRL1. SGK and Akt display differences with respect to the efficacy with which they phosphorylate the three regulatory sites on FKHRL1. While both kinases can phosphorylate Thr-32, SGK1 displays a marked preference for Ser-315 whereas Akt favors Ser-253. These findings suggest that SGK1 and Akt may coordinately regulate the function of FKHRL1 by phosphorylating this transcription factor at distinct sites. Like PKB, SGK1 preferentially phosphorylates Ser and Thr residues that lie in Arg-Xaa-Arg-Xaa-Xaa-Ser/Thr motifs. The SGK1 gene has recently been identified as an important aldosterone-induced protein kinase that mediates trafficking of the renal epithelial Na(+) channel (ENaC) to the cell membrane. Thus, SGK1 is an appealing candidate for blood pressure regulation and possibly essential hypertension.
Source :
E coli
Purity :
This protein is 90% pure as determined by SDS-PAGE Analysis.
Concentration :
0.1 mg/mL.
UniProt ID :
O00141
company information
Creative BioMart
Creative BioMart provides quality recombinant proteins, diagnostic antibodies and antigens, diagnostic enzymes and pharmaceutical enzymes to the research community of biology, clinical research, molecular diagnostics and biopharmaceutical drug development.
We are offering more than 3,000 recombinant proteins, peptides and antibodies. All the products are rigorously tested to meet the most demanding research needs. At the same time, lowest prices in the industry are always guaranteed.
Also, in order to leverage our core competencies and resources, Creative BioMart has formed a large number of corporate partnerships and academic collaborations for product development and distribution. We welcome potential partners and distributors to explore business relationships with Creative BioMart.
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