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product summary
company name :
Creative BioMart
product type :
protein
product name :
Recombinant Human Regenerating Islet-derived 3 Alpha, His-tagged
catalog :
REG3A-173H
product information
Cat :
REG3A-173H
Product Name :
Recombinant Human Regenerating Islet-derived 3 Alpha, His-tagged
Brand :
Creative Biomart
gene symbal :
REG3A
gene name :
regenerating islet-derived 3 alpha
Synonyms :
REG3A; regenerating islet-derived 3 alpha; pancreatitis associated protein , PAP; regenerating islet-derived protein 3-alpha; HIP; PAP1; PBCGF; REG III; REG3; Hepatocarcinoma intestine pancreas; Human proislet peptide; INGAP; Pancreatic beta cell growth factor; Pancreatitis associated protein 1; Pancreatitis associated protein; Pancreatitis-associated protein 1; PAP; PAP H; PAP homologous protein; Proliferation inducing protein 34; Proliferation inducing protein 42; Reg III alpha; Reg III-alpha; REG-3-alpha; REG3A_HUMAN; Regenerating islet derived 3 alpha; Regenerating islet derived protein 3 alpha precursor; Regenerating islet-derived protein III-alpha; proliferation-inducing protein 34; proliferation-inducing protein 42; hepatocarcinoma-intestine-pancreas; PAP-H; REG-III
Product Overview :
The Recombinant Human regenerating islet-derived 3 alpha(His-tagged) protein produced in E.coli contains 149 amino acids and has a molecular mass of 18.4 kDa.
Description :
The Recombinant Human regenerating islet-derived 3 alpha(His-tagged) protein produced in E.coli contains 149 amino acids and has a molecular mass of 18.4 kDa.Pancreatitis-associated protein (PAP) is a secretory protein not normally expressed in healthy pancreas but highly induced during acute pancreatitis. While PAP has been shown to be anti-bacterial and antiapoptotic in vitro, its definitive biological function in vivo is not clear. Using antisepse oligonucleotides, inhibition of PAP expression significantly worsened pancreatitis in a rat model. During pancreatitis, PAP released by the pancreas could mediate lung inflammation PAP is activated in primary liver cancers. In normal liver, the protein is undetectable in normal mature hepatocytes and found only in some ductular cells, representing potential hepatic progenitor cells. PAP can be considered hepatic cytokine that combines mitogenic and anti-apoptotic functions regarding hepatocytes, and consequently acts as a growth factor in vivo to enhance liver regeneration. In pancreatic cancor, PAP was overexpressed in 79% (30 of 38) of pancreatic ductal adenocarcinoma, 19% (7 of 36) of chronic pancreatitis, and 29% (2 of 7) of mucinous cystadenoma.
Source :
Escherichia Coli
Purity :
Greater than 95.0% as determined by SDS-PAGE.
Sequences Of Amino Acids :
MRGSHHHHHH GMASHMEEPQ RELPSARIRC PKGSKAYGSH CYALFLSPKS WTDADLACQK RPSGNLVSVL SGAEGSFVSS LVKSIGNSYS YVWIGLHDPT QGTEPNGEGW EWSSSDVMNY FAWERNPSTI SSPGHCASLS RSTAFLRWKD YNCNVRLPYV CKFTD.
UniProt ID :
Q06141
company information
Creative BioMart
Creative BioMart provides quality recombinant proteins, diagnostic antibodies and antigens, diagnostic enzymes and pharmaceutical enzymes to the research community of biology, clinical research, molecular diagnostics and biopharmaceutical drug development.
We are offering more than 3,000 recombinant proteins, peptides and antibodies. All the products are rigorously tested to meet the most demanding research needs. At the same time, lowest prices in the industry are always guaranteed.
Also, in order to leverage our core competencies and resources, Creative BioMart has formed a large number of corporate partnerships and academic collaborations for product development and distribution. We welcome potential partners and distributors to explore business relationships with Creative BioMart.
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