This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Creative BioMart
product type :
protein
product name :
Recombinant Human Retinoblastoma 1
catalog :
RB1-1192H
product information
Cat :
RB1-1192H
Product Name :
Recombinant Human Retinoblastoma 1
Brand :
Creative Biomart
gene symbal :
RB1
gene name :
retinoblastoma 1
Synonyms :
RB1; retinoblastoma 1; RB; pRb; OSRC; pp110; p105-Rb; retinoblastoma-associated protein; retinoblastoma suspectibility protein; prepro-retinoblastoma-associated protein;
Product Overview :
Recombinant protein production has become an essential tool for providing the necessary amounts of a protein of interest to either research or therapy by providing adequate amounts of proteins for studying protein structure and function. Moreover, scaled-up facilities produce recombinant vaccines, hormones, antibodies, growth factors, blood components, and enzymes.
Description :
PRB, the product of retinoblastoma susceptibility gene RB-1, is one of the best-studied tumor suppressor gene products. At least two other pRB-related proteins, p107 and p130, have been identified and characterized. Mutations in RB-1 gene are often associated with the occurrence of various tumors. The activity of pRB is regulated through phosphorylation in a cell cycle-dependent manner. The hyperphosphorylated RB protein usually associates with the cell nucleus and binds transcription factors of E2F family. pRB represses transcription of its target genes, such as cdc2, cyclin A, and oncogene c-myc, c-fos through the binding with E2F factors and thereby regulating cell proliferation. The wild type pRB (residue1-928) is expressed in baculovirus system and purified by an affinity column in combination with FPLC chromatography. Purified protein is greater than 95% homogeneous and contains no detectable proteases, DNase, and RNase activity.
Source :
Sf9 insect cells
Form :
Liquid. Supplied in 20 mM Tris-HCl pH 8.0, 100 mM KCl, 0.2 mM EDTA, 1 mM DTT and 20% glycerol.
Purity :
95% by SDS-PAGE.
Storage :
Quality guaranteed for 12 months, store at -80℃. Avoid freeze / thaw cycles.
UniProt ID :
P06400
company information
Creative BioMart
Creative BioMart provides quality recombinant proteins, diagnostic antibodies and antigens, diagnostic enzymes and pharmaceutical enzymes to the research community of biology, clinical research, molecular diagnostics and biopharmaceutical drug development.
We are offering more than 3,000 recombinant proteins, peptides and antibodies. All the products are rigorously tested to meet the most demanding research needs. At the same time, lowest prices in the industry are always guaranteed.
Also, in order to leverage our core competencies and resources, Creative BioMart has formed a large number of corporate partnerships and academic collaborations for product development and distribution. We welcome potential partners and distributors to explore business relationships with Creative BioMart.
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