This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Creative BioMart
product type :
protein
product name :
Recombinant Human RARA, Ligand Binding Domain
catalog :
RARA-1130H
product information
Cat :
RARA-1130H
Product Name :
Recombinant Human RARA, Ligand Binding Domain
Brand :
Creative Biomart
gene symbal :
RARA
gene name :
retinoic acid receptor, alpha
Synonyms :
RARA; retinoic acid receptor, alpha; retinoic acid receptor alpha; NR1B1; RAR; RAR-alpha; retinoic acid receptor, alpha polypeptide; nuclear receptor subfamily 1 group B member 1; retinoic acid nuclear receptor alpha variant 1; retinoic acid nuclear recep
Product Overview :
Recombinant protein production has become an essential tool for providing the necessary amounts of a protein of interest to either research or therapy by providing adequate amounts of proteins for studying protein structure and function. Moreover, scaled-up facilities produce recombinant vaccines, hormones, antibodies, growth factors, blood components, and enzymes.
Description :
Recombinant His tagged RAR alpha Ligand Binding Domain was expressed in an E. coli system and purified by affinity and FPLC chromatography. Several members of nuclear receptor family are directly associated with human malignancies including breast cancer, prostate cancer and leukemia. The pathogenesis of each of these diseases is underpinned by the activities of a member of the superfamily; Estrogen Receptor-alpha (ER-α) in breast cancer, Androgen Receptor (AR) in prostate cancer, and Retinoic Acid Receptor alpha (RAR-α) in acute promyelocytic leukemia. Retinoic acid receptors are important in the regulation of growth and differentiation of epithelial tissues, embryonic and central nervous system development and hematopoiesis. Retinoids mediate their effect by two classes of nuclear receptor proteins, the Retinoic Acid Receptors (RARs) and the Retinoid X Receptors (RXRs), that each consists of three isotypes (α,β, and γ) encoded in separate genes. Upon dimerization with RXR, RARs can bind to specific enhancer sequences in the DNA, so-called Retinoic Acid Response Elements (RAREs), resulting in transcriptional activation of target genes in the presence of ligand. The RAR-α gene is the target of chromosomal rearrangements in all cases of acute promyelocytic leukemia (APL). RAR-α is a negative regulator of promyelocyte differentiation when not complexed with RA, and stimulates this differentiation when bound to RA. Recombinant RAR-α-LBD was expressed in a baculovirus system and purified by an affinity column in combination with FPLC chromatography.
Source :
Sf9 insect cells
Form :
Liquid. Supplied in 20 mM Tris-HCl pH 8.0, 20% glycerol, 100 mM KCl, 0.2 mM EDTA and 1 mM DTT.
Purity :
90% by SDS-PAGE.
Storage :
Quality guaranteed for 12 months. Store at -80 C. Avoid freeze / thaw cycles.
UniProt ID :
P10276
company information
Creative BioMart
Creative BioMart provides quality recombinant proteins, diagnostic antibodies and antigens, diagnostic enzymes and pharmaceutical enzymes to the research community of biology, clinical research, molecular diagnostics and biopharmaceutical drug development.
We are offering more than 3,000 recombinant proteins, peptides and antibodies. All the products are rigorously tested to meet the most demanding research needs. At the same time, lowest prices in the industry are always guaranteed.
Also, in order to leverage our core competencies and resources, Creative BioMart has formed a large number of corporate partnerships and academic collaborations for product development and distribution. We welcome potential partners and distributors to explore business relationships with Creative BioMart.
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