This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Creative BioMart
product type :
protein
product name :
Recombinant Human PLAT, Fc-tagged
catalog :
PLAT-8525H
product information
Cat :
PLAT-8525H
Product Name :
Recombinant Human PLAT, Fc-tagged
Brand :
Creative Biomart
gene symbal :
PLAT
gene name :
plasminogen activator, tissue
Synonyms :
PLAT; plasminogen activator, tissue; TPA; T-PA; DKFZp686I03148; tissue-type plasminogen activator; alteplase; reteplase; OTTHUMP00000225783; OTTHUMP00000225784; OTTHUMP00000225785; OTTHUMP00000225786; OTTHUMP00000225787; OTTHUMP00000225788; t-plasminogen activator; plasminogen activator, tissue type; tissue plasminogen activator (t-PA)
Product Overview :
A DNA sequence encoding the α chain ( Tyr 37- Arg 310 ) of mature human tPA (NP_000921.1) was expressed with the fused Fc region of human IgG1 at the N-terminus.
Description :
A DNA sequence encoding the α chain ( Tyr 37- Arg 310 ) of mature human tPA (NP_000921.1) was expressed with the fused Fc region of human IgG1 at the N-terminus.PLAT, also known as plasminogen activator and tissue plasminogen activator, is a member of the peptidase S1 family. It is a heterodimer of chain A and chain B held by a disulfide bond. PLAT contains 1 EGF-like domain, 1 fibronectin type-I domain and 2 kringle domains. It is synthesized in numerous tissues (including tumors) and secreted into most extracellular body fluids, such as plasma, uterine fluid, saliva, gingival crevicular fluid, tears, seminal fluid, and milk. PLAT forms heterodimer with SERPINA5. It binds to fibrin with high affinity. It also binds to annexin A2, cytokeratin-8, fibronectin and laminin. Increased activity of plasminogen activator results in increased fibrinolysis of fibrin blood clots that is associated with excessive bleeding. Defective release of plasminogen activator results in hypofibrinolysis that can lead to thrombosis or embolism.
Source :
Human Cells
Form :
Lyophilized from sterile 50mM NaAc, 150mM NaCl, 5mM CaCl2, 10%glycerol, PH5.5. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization.
Purity :
>95 % as determined by SDS-PAGE
Storage :
Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
UniProt ID :
P00750
company information
Creative BioMart
Creative BioMart provides quality recombinant proteins, diagnostic antibodies and antigens, diagnostic enzymes and pharmaceutical enzymes to the research community of biology, clinical research, molecular diagnostics and biopharmaceutical drug development.
We are offering more than 3,000 recombinant proteins, peptides and antibodies. All the products are rigorously tested to meet the most demanding research needs. At the same time, lowest prices in the industry are always guaranteed.
Also, in order to leverage our core competencies and resources, Creative BioMart has formed a large number of corporate partnerships and academic collaborations for product development and distribution. We welcome potential partners and distributors to explore business relationships with Creative BioMart.
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