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product summary
company name :
Creative BioMart
product type :
protein
product name :
Recombinant Bovine PIK3R1
catalog :
PIK3R1-05B
product information
Cat :
PIK3R1-05B
Product Name :
Recombinant Bovine PIK3R1
Brand :
Creative Biomart
gene symbal :
PIK3R1
gene name :
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
Synonyms :
PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha); phosphatidylinositol 3-kinase regulatory subunit alpha; GRB1; p85; p85 ALPHA; PI3-kinase subunit p85-alpha; PI3K regulatory subunit alpha; ptdIns-3-kinase regulatory subunit alpha; phosphati
Product Overview :
Recombinant Bovine Phosphoinositide 3-kinase subunit p85a is expressed inLeishmania tarentolaeand has a molecular weight of 83.5 kDa.
Description :
Recombinant Bovine Phosphoinositide 3-kinase subunit p85a is expressed inLeishmania tarentolaeand has a molecular weight of 83.5 kDa.P85a functions as the regulatory subunit of the class IA PI3-kinase isoforms a, b, and d. It contains two SH2 domains that bind to tyrosine-phosphorylated growth factor receptors or substrate adaptor proteins. It also contains a breakpoint cluster region homology domain that shows GAP activity towards the small GTPases Rab4, Rab5, Cdc42, Rac1 and to a lesser extend towards Rab6 and Rab11. It was shown that PI3Ka catalytic subunit mediated phosphorylation of the p85a adapter reduces the lipid kinase activity of the heterodimer and this gives hints for PI3K-dependent signaling events not requiring production of 3'-phosphorylated phosphoinositides. PI3Ka protein kinase activity has been implicated in IRS-1 serine phosphorylation in insulin-treated adipocytes and in STAT3 and IRS-1 phosphorylation upon activation of the type 1 IFN receptor by IFN-a.
Source :
Leishmania tarentolae
Purity :
Greater than 90.0% as determined by SDS-PAGE.
Storage :
P85a although stable at 14 C for 1 week, should be stored desiccated below -18 C . For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
UniProt ID :
P23727
company information
Creative BioMart
Creative BioMart provides quality recombinant proteins, diagnostic antibodies and antigens, diagnostic enzymes and pharmaceutical enzymes to the research community of biology, clinical research, molecular diagnostics and biopharmaceutical drug development.
We are offering more than 3,000 recombinant proteins, peptides and antibodies. All the products are rigorously tested to meet the most demanding research needs. At the same time, lowest prices in the industry are always guaranteed.
Also, in order to leverage our core competencies and resources, Creative BioMart has formed a large number of corporate partnerships and academic collaborations for product development and distribution. We welcome potential partners and distributors to explore business relationships with Creative BioMart.
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