protein

Recombinant Human Nuclear R eceptor Subfamily 1, Group D, Member 2

NRID2-1150H

Recombinant Human Nuclear R eceptor Subfamily 1, Group D, Member 2

Creative Biomart

NR1D2

nuclear receptor subfamily 1, group D, member 2

NR1D2; nuclear receptor subfamily 1, group D, member 2; nuclear receptor subfamily 1 group D member 2; BD73; EAR 1r; Hs.37288; HZF2; RVR; EAR-1R; NR1D2_HUMAN; Orphan nuclear hormone receptor BD73; Rev erb beta; Rev-erb-beta; REVB; REVERBB; V-erbA-related protein 1-related; OTTHUMP00000208397; rev-erba-alpha-related receptor; nuclear receptor Rev-ErbA beta variant 1; nuclear receptor Rev-ErbA beta var

Recombinant protein production has become an essential tool for providing the necessary amounts of a protein of interest to either research or therapy by providing adequate amounts of proteins for studying protein structure and function. Moreover, scaled-up facilities produce recombinant vaccines, hormones, antibodies, growth factors, blood components, and enzymes.

Nuclear receptors form the largest known family of transcription factors and have a crucial role in nearly all aspects of vertebrate development and adult physiology by transducing the effects of hormones into transcriptional responses. The Rev-erb family of proteins are orphan members of the receptor superfamily. Two isoforms of the Rev-erb family have been isolated from mammalian genotypes, Rev-erbA [alpha] and Rev-erbA [beta]/RVR. Major differences between the two isoforms occur within the hyper-variable A/B and D regions of the proteins. The Rev-erb family has also been demonstrated to bind as homodimers to novel HREs consisting of two tandemly arranged AGGTCA motifs, separated by 2 bp with unique 5' flanking and spacer nucleotides (RevDR-2). Reports on the transcriptional properties of the Reverb family were initially conflicting. Rev-erbA [alpha] was first reported to act as a constitutive activator of transcription through its cognate monomeric asymmetric motif. Recently, it has been demonstrated that members of the Rev-erb family are, in fact, dominant repressors of transcription. Rev-erbA [beta] is expressed in the central nervous system, skeletal and dorsal muscles, spleen and mandibular and maxillar processes. During embryogenesis RVR is expressed in the notochord and neural tube, but its function/role during differentiation and mammalian development remains obscure.

Sf9 insect cells

Liquid. Supplied in 20 mM Tris-HCl pH 8.0, 20% glycerol, 100 mM KCl, 0.2 mM EDTA and 1 mM DTT.

95% by SDS-PAGE.

Quality guaranteed for 12 months, Store at -80℃. Avoid freeze / thaw cycles.

Q14995