This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Creative BioMart
product type :
protein
product name :
Recombinant Human NR1H2, His-tagged
catalog :
NR1H2-2503H
product information
Cat :
NR1H2-2503H
Product Name :
Recombinant Human NR1H2, His-tagged
Brand :
Creative Biomart
gene symbal :
NR1H2
gene name :
nuclear receptor subfamily 1, group H, member 2
Synonyms :
NR1H2; nuclear receptor subfamily 1, group H, member 2; NER; UNR; LXRB; LXR-b; NER-I; RIP15; oxysterols receptor LXR-beta; LX receptor beta; nuclear receptor NER; liver X nuclear receptor beta; nuclear orphan receptor LXR-beta; steroid hormone-nuclear receptor NER; ubiquitously-expressed nuclear receptor;
Product Overview :
Recombinant human His tagged LXR-β is isolated from anE. colistrain that carries the coding sequence of the human LXR-β under the control of a T7 promoter.62 kDa.
Description :
Recombinant human His tagged LXR-β is isolated from anE. colistrain that carries the coding sequence of the human LXR-β under the control of a T7 promoter.62 kDa.Liver X receptors (LXRs) are nuclear receptors that regulate the metabolism of cholesterol and bile acids. There are two subtypes of LXRs, LXRα and LXR-β. LXR-β is preferentially expressed in liver, small intestine, kidney and spleen. In contrast, LXRα expression is ubiquitous. The genomic structure and the promoter regions of the two LXR genes contain specific regulatory sites, which suggest that LXRs may have physiological roles in the immune system. Like other nuclear receptors, LXRs heterodimerize with retinoid X receptor (RXR) for function. LXRs are activated by naturally occurring oxysterols and regulate the expression of target genes, including ATP binding cassette transporter 1 (ABC1), ATP binding cassette transporter 8 (ABC8) and cholesterol ester transfer protein (CETP). LXR-β expressed in livers of LXRα knockout mice does not compensate for the loss of LXRα. In addition, LXR-β, but not LXRα, is also able to activate transcription of a reporter gene, which contains a specific direct repeat separated by 1 bp (DR1) element in the promoter, suggesting that LXR-β may have different biological functions.
Source :
E coli
UniProt ID :
P55055
company information
Creative BioMart
Creative BioMart provides quality recombinant proteins, diagnostic antibodies and antigens, diagnostic enzymes and pharmaceutical enzymes to the research community of biology, clinical research, molecular diagnostics and biopharmaceutical drug development.
We are offering more than 3,000 recombinant proteins, peptides and antibodies. All the products are rigorously tested to meet the most demanding research needs. At the same time, lowest prices in the industry are always guaranteed.
Also, in order to leverage our core competencies and resources, Creative BioMart has formed a large number of corporate partnerships and academic collaborations for product development and distribution. We welcome potential partners and distributors to explore business relationships with Creative BioMart.
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