This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Creative BioMart
product type :
protein
product name :
Recombinant Human Noggin
catalog :
NOG-2745H
product information
Cat :
NOG-2745H
Product Name :
Recombinant Human Noggin
Brand :
Creative Biomart
gene symbal :
NOG
gene name :
noggin
Synonyms :
NOG; noggin
Product Overview :
Recombinant human Noggin is a 23.1 kDa non-disulfide-linked homodimer consisting of a total of 206 amino acid residues. It was expressed inNicotiana benthamiana. Recombinant human noggin is purified by chromatography (FPLC). It contains no animal –derived components or impurities.
Description :
Recombinant human Noggin is a 23.1 kDa non-disulfide-linked homodimer consisting of a total of 206 amino acid residues. It was expressed inNicotiana benthamiana. Recombinant human noggin is purified by chromatography (FPLC). It contains no animal –derived components or impurities.Noggin is a secreted homodimeric glycoprotein that belongs to a group of diffusible proteins which bind to ligands of the TGF-beta family and regulate their activity by inhibiting their access to signaling receptors. Noggin has a complex pattern of expression during embryogenesis, and is expressed in the central nervous system, as well as in several peripheral tissues such as lung, skeletal muscle, and skin in adult. It plays a crucial role in bone development, by regulating the functions of BMP"s. Noggin binds the bone morphogenetic proteins (BMP) such as BMP-4 and BMP-7, and inhibits BMP signaling by blocking the molecular interfaces of the binding epitopes for both type I and type II receptors. During the morphogenisis of organs such as the lungs, teeth and hair follicles, noggin helps to produce Lef1. Interaction of BMP and its antagonist Noggin governs various developmental and cellular processes, including embryonic dorsal-ventral axis, induction of neural tissue, formation of joints in the skeletal system and neurogenesis in the adult brain.
Source :
Nicotiana benthamiana
Storage :
This lyophilized preparation is stable at 2-8 C, but should be kept at –20 C for long term storage. The product, as supplied is stable for at least 2 years. Diluted solutions are less stable than concentrated ones. Repeated freezing and thawing is not recommended.
UniProt ID :
Q13253
company information
Creative BioMart
Creative BioMart provides quality recombinant proteins, diagnostic antibodies and antigens, diagnostic enzymes and pharmaceutical enzymes to the research community of biology, clinical research, molecular diagnostics and biopharmaceutical drug development.
We are offering more than 3,000 recombinant proteins, peptides and antibodies. All the products are rigorously tested to meet the most demanding research needs. At the same time, lowest prices in the industry are always guaranteed.
Also, in order to leverage our core competencies and resources, Creative BioMart has formed a large number of corporate partnerships and academic collaborations for product development and distribution. We welcome potential partners and distributors to explore business relationships with Creative BioMart.
questions and comments