protein

Recombinant Human Matrix Metallopeptidase 8, Catalytic Domain

MMP8-154H

Recombinant Human Matrix Metallopeptidase 8, Catalytic Domain

Creative Biomart

MMP8

matrix metallopeptidase 8 (neutrophil collagenase)

MMP8; matrix metallopeptidase 8 (neutrophil collagenase); HNC; CLG1; MMP-8; PMNL-CL; neutrophil collagenase; PMNL collagenase; matrix metalloproteinase-8; matrix metalloproteinase 8 (neutrophil collagenase);

Recombinant Human matrix metalloproteinase-8 (MMP-8, collagenase-2, neurophil collagenase) cloned from human cDNA, expressed inE. coli.The enzyme consists of the catalytic domain of human MMP-8 (residues 105-262 swissprot accession P22894). MW=17.7kDa.

Recombinant Human matrix metalloproteinase-8 (MMP-8, collagenase-2, neurophil collagenase) cloned from human cDNA, expressed inE. coli.The enzyme consists of the catalytic domain of human MMP-8 (residues 105-262 swissprot accession P22894). MW=17.7kDa.Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP"s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens.

EColi

95% by SDS-PAGE. The enzyme was observed as a single band migrating at a molecular weight of 20 kDa.

-80 C. The enzyme is stable at -20 C for at least 1 week. After initial defrost, aliquot enzyme into individual tubes and refreeze at -80 C. Avoid repeated freeze/defrost cycles.

P22894