protein

Recombinant Human LGALS3

LGALS3-3622H

Recombinant Human LGALS3

Creative Biomart

LGALS3

lectin, galactoside-binding, soluble, 3

L31; GAL3; MAC2; CBP35; GALBP; GALIG; LGALS3; Galactose specific lectin 3; L34; L-31; L-34; Laminin binding protein; Lectin L 29; MGC105387; Galectin-3; LGALS3; CBP35; GAL3; GALBP; GALIG; L31; LGALS2; MAC2; 35 kDa lectin; IgE-binding protein; MAC-2 antigen; carbohydrate-binding protein 35; galactose-specific lectin 3; laminin-binding protein; lectin L-29

Recombinant Human Galectin-3 produced in E. coli is a single, non-glycosylated, polypeptide chain containing 250 amino acids and having a molecular mass of 26 kDa.

Recombinant Human Galectin-3 produced in E. coli is a single, non-glycosylated, polypeptide chain containing 250 amino acids and having a molecular mass of 26 kDa.Galectins are a family of animal lectins with an affinity for β-galactosides. There are at least 14 members identified. Galectins share similarities in carbohydrate recognition domain (CRD). Galectins are synthesized as cytosolic proteins. Although localized primarily in the cytoplasm and lacking a classical signal peptide, galectins can also be stimulated to secretion by non-classical pathways or alternatively targeted to the nucleus.Galectins are implicated in modulating cell-cell and cell-matrix interactions. Galectin-3, like all galectins, contains a CRD, while having a distinct chimeric structure with an extra N-terminal tail consisting of 8-13 copies of a 9 aa-repeat consensus sequence that is rich in proline, tyrosine, and glycine. Galectin-3 shares sequence similarity with apoptosis suppressor protein Bcl-2, and due to the Bcl-2-like function,it has been associated with the inhibition of apoptosis and tumor progression. Galectin-3 has also been demonstrated to be involved in heart and skin diseases.

The protein was lyophilized from a concentrated (1mg/ml) solution in 20mM PBS, pH 7.4.

Greater than 95% as determined by (a) Analysis by RP-HPLC; (b) Analysis by reducing and non-reducing SDS-PAGE Silver Stained gel.

Lyophilized rHuGalectin-3 although stable at room temperature for 3 weeks, should be stored desiccated below -18 C. Upon reconstitution rHuGalectin-3 should be stored at 4 C between 2-7 days and for future use below -18 C. For long-term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles.

P17931