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product summary
company name :
Creative BioMart
product type :
protein
product name :
Recombinant Human Leptin Receptor
catalog :
LEPR-1249H
product information
Cat :
LEPR-1249H
Product Name :
Recombinant Human Leptin Receptor
Brand :
Creative Biomart
gene symbal :
LEPR
gene name :
leptin receptor
Synonyms :
OBR; OB-R; CD295; LEP-R; LEPR; leptin receptor
Product Overview :
Recombinant Human Leptin Binding Domain also called Leptin soluble receptor produced in E.coli is a single, non-glycosylated, polypeptide chain containing 208 amino acids and having a molecular mass of 24.5 kDa. Leptin Receptor consists of the cytokine binding domain of leptin receptor amino acids 428-635 of human leptin receptor. The Leptin Binding Domain is purified by proprietary chromatographic techniques.
Description :
Recombinant Human Leptin Binding Domain also called Leptin soluble receptor produced in E.coli is a single, non-glycosylated, polypeptide chain containing 208 amino acids and having a molecular mass of 24.5 kDa. Leptin Receptor consists of the cytokine binding domain of leptin receptor amino acids 428-635 of human leptin receptor. The Leptin Binding Domain is purified by proprietary chromatographic techniques.Leptin receptor (LEPR), also known as OB-R and B219, is a single-transmembrane domain receptor of the cytokine receptor family. Leptin receptor exists as homodimer and binds Leptin with high affinity, thus mediates the biological function of the adipocyte-specific hormone Leptin. LEPR is expressed at high levels in hematopoietic stem cells, lymphohematopoietic cell lines, as well as adult reproductive organs. Several isoforms of LEPR have been identified, and LEPR structurally contains two hemopoietin receptor domains, a fibronectin type III domain and a WSXWS domain within the extracellular region. Interaction of leptin and leptin receptor is crucial for body weight and bone mass regulation in mammals through hypothalamic effects on satiety and energy expenditure. Meanwhile, research data supports a leptin receptor activation model based on ligand-induced conformational changes.
Source :
Escherichia Coli
Purity :
Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
UniProt ID :
P48357
company information
Creative BioMart
Creative BioMart provides quality recombinant proteins, diagnostic antibodies and antigens, diagnostic enzymes and pharmaceutical enzymes to the research community of biology, clinical research, molecular diagnostics and biopharmaceutical drug development.
We are offering more than 3,000 recombinant proteins, peptides and antibodies. All the products are rigorously tested to meet the most demanding research needs. At the same time, lowest prices in the industry are always guaranteed.
Also, in order to leverage our core competencies and resources, Creative BioMart has formed a large number of corporate partnerships and academic collaborations for product development and distribution. We welcome potential partners and distributors to explore business relationships with Creative BioMart.
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