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product summary
company name :
Creative BioMart
product type :
protein
product name :
Recombinant Human Jun Oncogene, GST-tagged
catalog :
JUN-646H
product information
Cat :
JUN-646H
Product Name :
Recombinant Human Jun Oncogene, GST-tagged
Brand :
Creative Biomart
gene symbal :
JUN
gene name :
jun proto-oncogene
Synonyms :
JUN; jun proto-oncogene; jun oncogene ,v jun avian sarcoma virus 17 oncogene homolog ,v jun sarcoma virus 17 oncogene homolog (avian); transcription factor AP-1; AP 1; c Jun; Activator Protein 1; AP 1; AP1; cJun; Enhancer Binding Protein AP1; Jun Activation Domain Binding Protein; JUN; Jun oncogene; JUN protein; Jun proto oncogene; JUN_HUMAN; JUNC; Oncogene JUN; p39; Proto oncogene c jun; Proto oncogene cJun; Proto-oncogene c-jun; Transcription Factor AP 1; Transcription factor AP-1; Transcription Factor AP1; V jun avian sarcoma virus 17 oncogene homolog; V jun sarcoma virus 17 oncogene homolog (avian); V-jun avian sarcoma virus 17 oncogene homolog; vJun Avian Sarcoma Virus 17 Oncogene Homolog; p39; jun oncogene; OTTHUMP00000010036; activator protein 1; proto-oncogene c-Jun; enhancer-binding protein AP1; Jun activation domain binding protein; v-jun sarcoma virus 17 oncogene homolog; v-jun avian sarcoma virus 17 oncogene homolog; AP1; AP-1; c-Jun
Product Overview :
Recombinant Human Jun Oncogene was expressed in E. coli. It was fused at the N-terminus to a GST tag. MW=68 KDa.
Description :
Recombinant Human Jun Oncogene was expressed in E. coli. It was fused at the N-terminus to a GST tag. MW=68 KDa.c-Jun is an important proto-oncogene and transactivating factor that is a component of the AP-1 and ATF-2 transcription factors. c-Jun is acutely regulated by a wide variety of cellular signals via modulation of its phosphorylation state, which can both inhibit and activate the proto-oncogene. Phosphorylation by GSK-3 at a region proxim al to the highly basic DNA binding domain (Thr239/Ser243/Ser249) prevents DNA association with c-Jun homodimers, but not with c-Jun-c-Fos heterodimers. Phosphorylation catalyzed by JNK/SAPK at Ser63 and Ser73, in a region proximal to the transactivation domain, activates the c-Jun/AP-1 and c-Jun/ATF2 transcriptional activator complexes to induce a number of genes. The MAP kinases ERK1 and ERK2 also phosphorylate c-Jun at Thr91/Thr93/Thr95. The preparations are suitable for studies on the kinetics, enzymology and regulation of the phosphorylation of the important proto-oncogene. The purified preparations are effective as substrate for JNK/SAPK, MAPK, GSK-3 and CK-2 among other protein kinases.
Source :
E coli
Purity :
90% by SDS-PAGE.
Storage :
Maintain preparations in aliquots at -70 o C. Avoid repeated thawing.
UniProt ID :
P05412
company information
Creative BioMart
Creative BioMart provides quality recombinant proteins, diagnostic antibodies and antigens, diagnostic enzymes and pharmaceutical enzymes to the research community of biology, clinical research, molecular diagnostics and biopharmaceutical drug development.
We are offering more than 3,000 recombinant proteins, peptides and antibodies. All the products are rigorously tested to meet the most demanding research needs. At the same time, lowest prices in the industry are always guaranteed.
Also, in order to leverage our core competencies and resources, Creative BioMart has formed a large number of corporate partnerships and academic collaborations for product development and distribution. We welcome potential partners and distributors to explore business relationships with Creative BioMart.
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