This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Creative BioMart
product type :
protein
product name :
Recombinant Human Interleukin 27 Receptor, Alpha, Fc Chimera
catalog :
IL27RA-781H
product information
Cat :
IL27RA-781H
Product Name :
Recombinant Human Interleukin 27 Receptor, Alpha, Fc Chimera
Brand :
Creative Biomart
gene symbal :
IL27RA
gene name :
interleukin 27 receptor, alpha
Synonyms :
IL27RA; interleukin 27 receptor, alpha; interleukin-27 receptor subunit alpha; CRL1; IL 27R; T cell cytokine receptor type 1; TCCR; WSX 1; WSX1; zcytor1; IL-27RA; IL-27R-alpha; IL-27R subunit alpha; cytokine receptor-like 1; class I cytokine receptor; IL-
Product Overview :
Recombinant HumanIL27RA encoding the extracellular domain (Met1-Arg514) of human IL27Rα (NP_004834.1) pro-form was produced inE.coli.It was expressed with the C-terminal fused Fc region of human IgG1.
Description :
Recombinant HumanIL27RA encoding the extracellular domain (Met1-Arg514) of human IL27Rα (NP_004834.1) pro-form was produced inE.coli.It was expressed with the C-terminal fused Fc region of human IgG1.L27Rα (IL27R), also well known as WSX-1 and TCCR, is a type I cytokine receptor that functions only as the ligand binding component of the receptor for IL27, and together with the glycoprotein 130 (gp130) coreceptor constitutes a functional signal-transducing receptor mediating the IL27 effects. Neither receptor chain alone is sufficient independent of the other. As a member of the IL6/IL12 family of cytokines, IL27 is not only involved in the development of Th1-type adaptive immune response, but also acts on cells of the innate immune system. In addition, it has been demonstrated that IL27Rα, the single component of a heterodimeric cytokine receptor, can aberrantly activate signaling pathways and transform hematopoietic cells in a JAK-dependent manner in acute myeloid leukemia (AML). Accordingly, IL27Rα may play an unappreciated role in various myeloproliferative disorders (MPDs) and be identified as a future therapeutic target for this disease.
Source :
Escherichia Coli
Purity :
95%, as determined by SDS-PAGE.
Storage :
Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage and be used as soon as possible. Avoid repeated freeze-thaw cycles.
UniProt ID :
Q6UWB1
company information
Creative BioMart
Creative BioMart provides quality recombinant proteins, diagnostic antibodies and antigens, diagnostic enzymes and pharmaceutical enzymes to the research community of biology, clinical research, molecular diagnostics and biopharmaceutical drug development.
We are offering more than 3,000 recombinant proteins, peptides and antibodies. All the products are rigorously tested to meet the most demanding research needs. At the same time, lowest prices in the industry are always guaranteed.
Also, in order to leverage our core competencies and resources, Creative BioMart has formed a large number of corporate partnerships and academic collaborations for product development and distribution. We welcome potential partners and distributors to explore business relationships with Creative BioMart.
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