This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Creative BioMart
product type :
protein
product name :
Recombinant Human Interleukin 12B, Fc-Tagged
catalog :
IL12B-35H
product information
Cat :
IL12B-35H
Product Name :
Recombinant Human Interleukin 12B, Fc-Tagged
Brand :
Creative Biomart
gene symbal :
IL12B
gene name :
interleukin 12B
Synonyms :
40 kD Subunit; CLMF 2; CLMF; CLMF p40; CLMF2; Cytotoxic lymphocyte maturation factor 2; Cytotoxic lymphocyte maturation factor 2 p40; Cytotoxic lymphocyte maturation factor 40 kDa subunit; HGNC:5970; IL 12 subunit p40; IL 12B; IL-12 subunit p40; IL-12B; IL12 subunit p40; IL12B; IL12B_HUMAN; Interleukin 12 p40; Interleukin 12 subunit beta; Interleukin 12B; Interleukin-12 subunit beta; Interleukin12B; NK cell stimulatory factor chain 2; NKSF; NKSF2; p40; IL12 p40-Carboxyterminal end
Product Overview :
Recombinant Human Interleukin 12B, Fc-Tagged expressed in E.coli is a disulfide-linked homodimer. The reduced monomer consists of 544 amino acids and has a predicted molecular mass of 61.4 kDa. As a result of glycosylation, the rhIL12B/Fc monomer migrates as an approximately 70-80 kDa band in SDS-PAGE under reducing conditions.
Description :
Recombinant Human Interleukin 12B, Fc-Tagged expressed in E.coli is a disulfide-linked homodimer. The reduced monomer consists of 544 amino acids and has a predicted molecular mass of 61.4 kDa. As a result of glycosylation, the rhIL12B/Fc monomer migrates as an approximately 70-80 kDa band in SDS-PAGE under reducing conditions.Interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. A DNA sequence encoding the p40 subunit of human IL12, termed asIL12B (NP_002178.2) (Met 1- Ser 328 ) was fused with the Fc region ofhuman IgG1 at the C-terminus.
Purity :
95%, as determined by SDS-PAGE
Storage :
Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
company information
Creative BioMart
Creative BioMart provides quality recombinant proteins, diagnostic antibodies and antigens, diagnostic enzymes and pharmaceutical enzymes to the research community of biology, clinical research, molecular diagnostics and biopharmaceutical drug development.
We are offering more than 3,000 recombinant proteins, peptides and antibodies. All the products are rigorously tested to meet the most demanding research needs. At the same time, lowest prices in the industry are always guaranteed.
Also, in order to leverage our core competencies and resources, Creative BioMart has formed a large number of corporate partnerships and academic collaborations for product development and distribution. We welcome potential partners and distributors to explore business relationships with Creative BioMart.
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