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product summary
company name :
Creative BioMart
product type :
protein
product name :
Recombinant Human CYP2D6
catalog :
CYP2D6-225H
product information
Cat :
CYP2D6-225H
Product Name :
Recombinant Human CYP2D6
Brand :
Creative Biomart
gene name :
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 [ Homo sapiens ]
Synonyms :
CYP2D6; cytochrome P450, family 2, subfamily D, polypeptide 6; CPD6; CYP2D; CYP2DL1; CYPIID6; P450C2D; P450DB1; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; P450-DB1; cytochrome P450 2D6; cytochrome P450; subfamily IID (debrisoquine, sparteine, etc., -metabolizing); polypeptide 6; cytochrome P450; subfamily IID (debrisoquine, sparteine, etc., -metabolizing)-like 1; debrisoquine 4-hydroxylase; flavoprotein-linked monooxygenase; microsomal monooxygenase; xenobiotic monooxygenase
Product Overview :
Recombinant Human CYP2D6 was expressed in Baculovirus-Insect cells.
Description :
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme"s substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Source :
Microsomes prepared from insect cells infected with a baculovirus containing a cDNA for human CYP2D6 (valine at position 374) and rabbit cytochrome P450 oxidoreductase (CYPOR)
Storage :
80 Avoid multiple freeze-thaws
UniProt ID :
P10635
company information
Creative BioMart
Creative BioMart provides quality recombinant proteins, diagnostic antibodies and antigens, diagnostic enzymes and pharmaceutical enzymes to the research community of biology, clinical research, molecular diagnostics and biopharmaceutical drug development.
We are offering more than 3,000 recombinant proteins, peptides and antibodies. All the products are rigorously tested to meet the most demanding research needs. At the same time, lowest prices in the industry are always guaranteed.
Also, in order to leverage our core competencies and resources, Creative BioMart has formed a large number of corporate partnerships and academic collaborations for product development and distribution. We welcome potential partners and distributors to explore business relationships with Creative BioMart.
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