This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Creative BioMart
product type :
protein
product name :
Recombinant Human Baculoviral IAP Repeat-Containing 2, AVI-tagged
catalog :
BIRC2-3104H
product information
Cat :
BIRC2-3104H
Product Name :
Recombinant Human Baculoviral IAP Repeat-Containing 2, AVI-tagged
Brand :
Creative Biomart
gene symbal :
BIRC2
gene name :
baculoviral IAP repeat containing 2
Synonyms :
BIRC2; baculoviral IAP repeat containing 2; API1; MIHB; HIAP2; RNF48; cIAP1; Hiap-2; c-IAP1; baculoviral IAP repeat-containing protein 2; IAP-2; IAP homolog B; apoptosis inhibitor 1; RING finger protein 48; inhibitor of apoptosis protein 2; baculoviral IAP repeat-containing 2; NFR2-TRAF signalling complex protein; TNFR2-TRAF-signaling complex protein 2;
Product Overview :
Recombinant Human BIRC2 (Glu 144-Leu 356) with a AVI tag at C-terminus and additonal two amino acids (Gly Pro) at the N-terminus, was expressed in E.coli.
Description :
Recombinant Human BIRC2 (Glu 144-Leu 356) with a AVI tag at C-terminus and additonal two amino acids (Gly Pro) at the N-terminus, was expressed in E.coli.Baculoviral IAP repeat-containing protein 2, also known as Inhibitor of apoptosis protein 2, HIAP2, c-IAP1, RING finger protein 48, and BIRC2, is a member of the IAP family. The inhibitor of apoptosis (IAP) proteins are a family of anti-apoptotic regulators found in viruses and metazoans. The UBA (ubiquitin-associated) domain of IAPs is located between the BIR (baculovirus IAP repeat) domains and the CARD (caspase activation and recruitment domain) or the RING (really interesting new gene) domain of c-IAP1 and c-IAP2 or XIAP (X-linked IAP) respectively. c-IAP1 contains three BIR repeats, one CARD domain and one RING-type zinc finger. c-IAP1 and c-IAP2 are recruited to tumor necrosis factor receptor 1 (TNFR1) associated complexes where they can regulate receptor-mediated signaling. Both c-IAP1 and c-IAP2 have been implicated in TNFalpha-stimulated NF-kappaB activation. Treatment of cells with IAP antagonists leads to proteasomal degradation of c-IAP1 and c-IAP2. Deletion or mutation of the UBA domain decreases this degradation, probably by diminishing the interaction of the c-IAPs with the proteasome. Ubiquitin binding may be an important mechanism for rapid turnover of auto-ubiquitinated c-IAP1 and c-IAP2.
Purity :
92 % as determined by SDS-PAGE
Storage :
Store it under sterile conditions at -70 C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
UniProt ID :
Q13490
company information
Creative BioMart
Creative BioMart provides quality recombinant proteins, diagnostic antibodies and antigens, diagnostic enzymes and pharmaceutical enzymes to the research community of biology, clinical research, molecular diagnostics and biopharmaceutical drug development.
We are offering more than 3,000 recombinant proteins, peptides and antibodies. All the products are rigorously tested to meet the most demanding research needs. At the same time, lowest prices in the industry are always guaranteed.
Also, in order to leverage our core competencies and resources, Creative BioMart has formed a large number of corporate partnerships and academic collaborations for product development and distribution. We welcome potential partners and distributors to explore business relationships with Creative BioMart.
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