This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Creative BioMart
product type :
protein
product name :
Recombinant Human Beta-Site APP-Cleaving Enzyme 1
catalog :
BACE1-31H
product information
Cat :
BACE1-31H
Product Name :
Recombinant Human Beta-Site APP-Cleaving Enzyme 1
Brand :
Creative Biomart
gene symbal :
BACE1
gene name :
beta-site APP-cleaving enzyme 1
Synonyms :
BACE1; beta-site APP-cleaving enzyme 1; ASP2; BACE; HSPC104; beta-secretase 1; asp 2; memapsin-2; APP beta-secretase; aspartyl protease 2; beta-site APP cleaving enzyme 1; beta-secretase 1 precursor variant 1; transmembrane aspartic proteinase Asp2; membrane-associated aspartic protease 2; beta-site amyloid beta A4 precursor protein-cleaving enzyme;
Product Overview :
Recombinant Human BACE-1 is expressed in E.coli containing 366 amino acids 28-393. The BACE1 is purified by proprietary chromatographic techniques.
Description :
Recombinant Human BACE-1 is expressed in E.coli containing 366 amino acids 28-393. The BACE1 is purified by proprietary chromatographic techniques.Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer"s disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. BACE1 is a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Four transcript variants encoding different isoforms have been described for this gene. BACE1 is responsible for the proteolytic processing of the amyloid precursor protein (APP). BACE-1 cleaves at the n-terminus of the a-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated c-terminal fragment which is later released by gamma-secretase.
Source :
Escherichia Coli
Purity :
Greater than 95% as determined by SDS-PAGE.
UniProt ID :
P56817
company information
Creative BioMart
Creative BioMart provides quality recombinant proteins, diagnostic antibodies and antigens, diagnostic enzymes and pharmaceutical enzymes to the research community of biology, clinical research, molecular diagnostics and biopharmaceutical drug development.
We are offering more than 3,000 recombinant proteins, peptides and antibodies. All the products are rigorously tested to meet the most demanding research needs. At the same time, lowest prices in the industry are always guaranteed.
Also, in order to leverage our core competencies and resources, Creative BioMart has formed a large number of corporate partnerships and academic collaborations for product development and distribution. We welcome potential partners and distributors to explore business relationships with Creative BioMart.
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